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8KAE
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BU of 8kae by Molmil
16d-bound human SPNS2
Descriptor: 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, NbFab chain L, NbFab-H chain, ...
Authors:He, Y, Duan, Y.
Deposit date:2023-08-03
Release date:2024-01-03
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural basis of Sphingosine-1-phosphate transport via human SPNS2.
Cell Res., 34, 2024
8THR
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BU of 8thr by Molmil
Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation
Descriptor: (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one, fluorescent protein mVenus,Synaptic vesicular amine transporter,GFP nano body,Synaptic vesicular amine transporter,Synaptic vesicular amine transporter
Authors:Dalton, M.P, Coleman, J.A.
Deposit date:2023-07-17
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation
To Be Published
8PNL
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BU of 8pnl by Molmil
Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody
Descriptor: Nb_H2, Putative triacylglyceride transporter
Authors:Remm, S, Schoeppe, J, Hutter, C.A.J, Gonda, I, Seeger, M.A.
Deposit date:2023-06-30
Release date:2023-10-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410.
Nat Commun, 14, 2023
8JTA
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BU of 8jta by Molmil
Human VMAT2 complex with tetrabenazine
Descriptor: Synaptic vesicular amine transporter, tetrabenazine
Authors:Jiang, D.H, Wu, D.
Deposit date:2023-06-21
Release date:2023-11-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
8JT9
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BU of 8jt9 by Molmil
Human VMAT2 complex with ketanserin
Descriptor: 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter
Authors:Jiang, D.H, Wu, D.
Deposit date:2023-06-21
Release date:2023-11-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
8JTC
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BU of 8jtc by Molmil
Human VMAT2 complex with reserpine
Descriptor: Synaptic vesicular amine transporter, reserpine
Authors:Jiang, D.H, Wu, D.
Deposit date:2023-06-21
Release date:2023-11-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
8JSW
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BU of 8jsw by Molmil
Human VMAT2 complex with serotonin
Descriptor: SEROTONIN, Synaptic vesicular amine transporter
Authors:Jiang, D.H, Wu, D.
Deposit date:2023-06-20
Release date:2023-11-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
8T6A
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BU of 8t6a by Molmil
Human VMAT2 in complex with reserpine
Descriptor: Synaptic vesicular amine transporter, reserpine
Authors:Pidathala, S, Dai, Y, Lee, C.H.
Deposit date:2023-06-15
Release date:2023-11-01
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.
Nature, 623, 2023
8T69
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BU of 8t69 by Molmil
Human VMAT2 in complex with tetrabenazine
Descriptor: Synaptic vesicular amine transporter, tetrabenazine
Authors:Pidathala, S, Dai, Y, Lee, C.H.
Deposit date:2023-06-15
Release date:2023-11-01
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.
Nature, 623, 2023
8T6B
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BU of 8t6b by Molmil
Human VMAT2 in complex with serotonin
Descriptor: SEROTONIN, Synaptic vesicular amine transporter
Authors:Pidathala, S, Dai, Y, Lee, C.H.
Deposit date:2023-06-15
Release date:2023-11-01
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.
Nature, 623, 2023
8JHR
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BU of 8jhr by Molmil
Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d
Descriptor: 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2
Authors:Pang, B, Yu, L.Y, Ren, R.B.
Deposit date:2023-05-25
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Cell Res., 34, 2024
8JHQ
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BU of 8jhq by Molmil
Cryo-EM structure of human S1P transporter SPNS2 bound with S1P
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2,GlgA glycogen synthase
Authors:Pang, B, Yu, L.Y, Ren, R.B.
Deposit date:2023-05-25
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Cell Res., 34, 2024
8SDY
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BU of 8sdy by Molmil
Structure of rat organic anion transporter 1 (OAT1) in complex with para-aminohippuric acid (PAH)
Descriptor: N-(4-aminobenzoyl)glycine, Solute carrier family 22 member 6
Authors:Dou, T, Jiang, J.
Deposit date:2023-04-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8SDZ
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BU of 8sdz by Molmil
Structure of rat organic anion transporter 1 (OAT1) in complex with probenecid
Descriptor: 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6
Authors:Dou, T, Jiang, J.
Deposit date:2023-04-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8SDU
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BU of 8sdu by Molmil
Structure of rat organic anion transporter 1 (OAT1)
Descriptor: Solute carrier family 22 member 6
Authors:Dou, T, Jiang, J.
Deposit date:2023-04-07
Release date:2023-10-18
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (2.05 Å)
Cite:The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8SC1
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BU of 8sc1 by Molmil
Human OCT1 (Apo) in inward-open conformation
Descriptor: Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC4
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BU of 8sc4 by Molmil
Human OCT1 bound to metformin in inward-open conformation
Descriptor: Metformin, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC2
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BU of 8sc2 by Molmil
Human OCT1 bound to diltiazem in inward-open conformation
Descriptor: Diltiazem, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC3
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BU of 8sc3 by Molmil
Human OCT1 bound to fenoterol in inward-open conformation
Descriptor: Fenoterol, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC6
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BU of 8sc6 by Molmil
Human OCT1 bound to thiamine in inward-open conformation
Descriptor: 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Solute carrier family 22 member 1
Authors:Zeng, Y.C, Sobti, M, Stewart, A.G.
Deposit date:2023-04-04
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8OMU
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BU of 8omu by Molmil
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state
Descriptor: Solute carrier family 22 member 6, Synthetic nanobody (Sybody)
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2023-03-31
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8G92
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BU of 8g92 by Molmil
Structure of inhibitor 16d-bound SPNS2
Descriptor: 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2
Authors:Chen, H, Li, X.
Deposit date:2023-02-21
Release date:2023-05-24
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
8FVZ
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BU of 8fvz by Molmil
PiPT Y150A
Descriptor: CITRATE ANION, PHOSPHATE ION, Phosphate transporter
Authors:Gupta, M, Finer-Moore, J, Stroud, R.M.
Deposit date:2023-01-20
Release date:2024-01-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Roles of PiPT residues in phosphate binding and transport tested by mutagenesis
To be published
8BW7
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BU of 8bw7 by Molmil
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid
Descriptor: 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ...
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2022-12-06
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8BVT
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BU of 8bvt by Molmil
Cryo-EM structure of rat SLC22A6 bound to probenecid
Descriptor: 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6, Synthetic nanobody (Sybody)
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2022-12-06
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023

 

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PDB entries from 2024-03-27

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