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8VB1
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Crystal structure of HIV-1 protease with GS-9770
Descriptor: (2S)-2-{(3M)-4-chloro-3-[1-(difluoromethyl)-1H-1,2,4-triazol-5-yl]phenyl}-2-[(2E,4R)-4-[4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)phenyl]-2-imino-5-oxo-4-(3,3,3-trifluoro-2,2-dimethylpropyl)imidazolidin-1-yl]ethyl [1-(difluoromethyl)cyclopropyl]carbamate, HIV-1 protease
Authors:Lansdon, E.B.
Deposit date:2023-12-11
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob.Agents Chemother., 2024
8CI7
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BU of 8ci7 by Molmil
Apo-crystal structure of a wild-type South African HIV-1 subtype C protease at 2.4 angstrom
Descriptor: Truncated pol polyprotein
Authors:Dlamini, N.P, Pandian, R, Onisuru, O, Achilonu, I.A, Sayed, Y.
Deposit date:2023-02-09
Release date:2023-04-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biophysical and biochemical characterization of a wild-type South African HIV-1 subtype C protease
To Be Published
8FUJ
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HIV-1 wild type protease with GRL-03419A, with N-(2,5-dimethylphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine as P2-P3 group and 3,5-difluorophenylmethyl as the P1 group
Descriptor: CHLORIDE ION, FORMIC ACID, GLYCEROL, ...
Authors:Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T.
Deposit date:2023-01-17
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation.
Eur.J.Med.Chem., 255, 2023
8FUI
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HIV-1 wild type protease with GRL-02519A, with N-(2,5-dimethylphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine as P2-P3 group
Descriptor: ACETATE ION, CHLORIDE ION, FORMIC ACID, ...
Authors:Wang, Y.-F, Wong-Sam, A.E, Ghosh, A.K, Weber, I.T.
Deposit date:2023-01-17
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation.
Eur.J.Med.Chem., 255, 2023
8F0F
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BU of 8f0f by Molmil
HIV-1 wild type protease with GRL-110-19A, a chloroacetamide derivative based on Darunavir as P2' group
Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[4-(2-chloroacetamido)benzene-1-sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, GLYCEROL, ...
Authors:Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T.
Deposit date:2022-11-02
Release date:2023-02-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies.
Bioorg.Med.Chem.Lett., 83, 2023
8ESX
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HIV protease in complex with benzoxaborolone analog of darunavir
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Windsor, I.W, Graham, B.J, Raines, R.T.
Deposit date:2022-10-15
Release date:2023-02-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.
Acs Med.Chem.Lett., 14, 2023
8ESY
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BU of 8esy by Molmil
D30N mutant HIV protease in complex with benzoxaborolone analog of darunavir
Descriptor: CHLORIDE ION, GLYCEROL, Protease, ...
Authors:Windsor, I.W, Graham, B.J, Raines, R.T.
Deposit date:2022-10-15
Release date:2023-02-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.
Acs Med.Chem.Lett., 14, 2023
7YF6
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BU of 7yf6 by Molmil
Crystal structure of HIV-1 protease in complex with macrocyclic peptide
Descriptor: MAGNESIUM ION, Macrocyclic Peptide, Protease
Authors:Kusumoto, Y, Sato, S, Yamada, T, Kozono, I, Nakata, Z, Asada, N, Mitsuki, S, Wakasa-Morimoto, C, Tohru, M, Watanabe, A, Hayashi, K, Mikamiyama, H.
Deposit date:2022-07-07
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization.
Acs Med.Chem.Lett., 13, 2022
8DCI
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BU of 8dci by Molmil
Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x (inhibitor-free)
Descriptor: Protease
Authors:Wong-Sam, A.E, Wang, Y.-F, Weber, I.T.
Deposit date:2022-06-16
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.
J.Mol.Graph.Model., 117, 2022
8DCH
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Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x with GRL-0519 (tris-tetrahydrofuran as P2 ligand)
Descriptor: (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, GLYCEROL, ...
Authors:Wong-Sam, A.E, Wang, Y.-F, Weber, I.T.
Deposit date:2022-06-16
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.
J.Mol.Graph.Model., 117, 2022
7TO6
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BU of 7to6 by Molmil
HIV-1 wild type protease with GRL-01717A, with C-4 substituted cyclohexane-fused bis-tetrahydrofuran (Chf-THF) derivatives as P2-ligand [diastereomer 2]
Descriptor: (1S,3aR,4R,6R,7aS)-octahydro-1,6-epoxy-2-benzofuran-4-yl [(2S,3R)-4-{[2-(cyclopropylamino)-1,3-benzothiazole-6-sulfonyl](2-methylpropyl)amino}-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ...
Authors:Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T.
Deposit date:2022-01-23
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands.
Chemmedchem, 17, 2022
7TO5
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BU of 7to5 by Molmil
HIV-1 wild type protease with GRL-05816A, with C-4 substituted cyclohexane-fused bis-tetrahydrofuran (Chf-THF) derivatives as P2-ligand [diastereomer 1]
Descriptor: (1R,3aS,4S,6S,7aR)-octahydro-1,6-epoxy-2-benzofuran-4-yl [(2S,3R)-4-{[2-(cyclopropylamino)-1,3-benzothiazole-6-sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, FORMIC ACID, ...
Authors:Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T.
Deposit date:2022-01-23
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands.
Chemmedchem, 17, 2022
7WCQ
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BU of 7wcq by Molmil
Crystal structure of HIV-1 protease in complex with lactam derivative 1
Descriptor: (3R,4R)-3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-3-(4-methylsulfonylphenyl)-4-oxidanyl-pyrrolidin-2-one, Protease
Authors:Kojima, E, Iimuro, A, Nakajima, M, Kinuta, H, Asada, N, Sako, Y, Nakata, Z, Uemura, K, Arita, S, Miki, S, Wakasa-Morimoto, C, Tachibana, Y, Fumoto, M.
Deposit date:2021-12-20
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.
J.Med.Chem., 65, 2022
7WBS
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BU of 7wbs by Molmil
Crystal structure of HIV-1 protease in complex with lactam derivative 2
Descriptor: (3~{R},4~{R})-1-[(4-methoxyphenyl)methyl]-3-(3-methylbutyl)-3-[4-methylsulfonyl-2-[(2~{S})-1-oxidanylpropan-2-yl]oxy-phenyl]-4-oxidanyl-pyrrolidin-2-one, GLYCEROL, Protease
Authors:Kojima, E, Iimuro, A, Nakajima, M, Kinuta, H, Asada, N, Sako, Y, Nakata, Z, Uemura, K, Arita, S, Miki, S, Wakabayashi-Morimoto, C, Tachibana, Y, Fumoto, M.
Deposit date:2021-12-17
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.
J.Med.Chem., 65, 2022
7SJX
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BU of 7sjx by Molmil
Cryo-EM Structure of the PR-RT components of the HIV-1 Pol Polyprotein
Descriptor: Gag-Pol polyprotein
Authors:Lyumkis, D, Passos, D, Arnold, E, Harrison, J.J.E.K, Ruiz, F.X.
Deposit date:2021-10-19
Release date:2022-07-27
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation.
Sci Adv, 8, 2022
7SEP
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BU of 7sep by Molmil
Cryo-EM Structure of the RT component of the HIV-1 Pol Polyprotein
Descriptor: Gag-Pol polyprotein
Authors:Lyumkis, D, Passos, D, Arnold, E, Harrison, J.J.E.
Deposit date:2021-10-01
Release date:2022-07-27
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation.
Sci Adv, 8, 2022
7N6V
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BU of 7n6v by Molmil
Crystal structure of HIV-1 Protease multiple mutants PRS17 with Revertant mutation V48G bound to inhibitor Amprenavir
Descriptor: GLYCEROL, Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER
Authors:Burnaman, S.H, Wang, Y.-F, Weber, I.T.
Deposit date:2021-06-09
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
J.Mol.Graph.Model., 108, 2021
7N6X
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Crystal structure of HIV-1 Protease multiple mutants PRS17 bound to inhibitor Amprenavir
Descriptor: Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER
Authors:Burnaman, S.H, Wang, Y.-F, Weber, I.T.
Deposit date:2021-06-09
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
J.Mol.Graph.Model., 108, 2021
7N6T
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Crystal structure of inhibitor-free HIV-1 PRS17 revertant mutant PRS17 V48G
Descriptor: Protease
Authors:Burnaman, S.H, Wang, Y.-F, Weber, I.T.
Deposit date:2021-06-09
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
J.Mol.Graph.Model., 108, 2021
7MYY
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Crystal Structure of HIV-1 PRS17 with GRL-142
Descriptor: (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, CHLORIDE ION, GLYCEROL, ...
Authors:Agniswamy, J, Weber, I.T.
Deposit date:2021-05-22
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR S17 .
Biochem.Biophys.Res.Commun., 566, 2021
7MYP
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BU of 7myp by Molmil
Crystal Structure of HIV-1 PRS17 with GRL-44-10A
Descriptor: (3R,3aS,4R,6aR)-4-methoxyhexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, GLYCEROL, ...
Authors:Agniswamy, J, Weber, I.T.
Deposit date:2021-05-21
Release date:2021-07-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR S17 .
Biochem.Biophys.Res.Commun., 566, 2021
7MAL
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BU of 7mal by Molmil
HIV-1 Protease (I84V) in Complex with PU8 (LR4-06)
Descriptor: Protease, SULFATE ION, diethyl [(4-{(2S,3R)-4-[(2-ethylbutyl){[4-(hydroxymethyl)phenyl]sulfonyl}amino]-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate
Authors:Lockbaum, G.J, Schiffer, C.A.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:HIV-1 Protease (I84V) in Complex with PU8 (LR4-06)
To Be Published
7M9R
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BU of 7m9r by Molmil
HIV-1 Protease WT (NL4-3) in Complex with LR4-44
Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[{4-[(1S)-1-hydroxyethyl]benzene-1-sulfonyl}(2-methylpropyl)amino]butan-2-yl}carbamate, Protease, SULFATE ION
Authors:Lockbaum, G.J, Schiffer, C.A.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:HIV-1 Protease WT (NL4-3) in Complex with LR4-44
To Be Published
7MAC
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BU of 7mac by Molmil
HIV-1 Protease (I84V) in Complex with PD4 (LR4-23)
Descriptor: Protease, diethyl [(4-{(2S,3R)-4-{[(2H-1,3-benzodioxol-5-yl)sulfonyl](2-methylpropyl)amino}-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate
Authors:Lockbaum, G.J, Schiffer, C.A.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:HIV-1 Protease (I84V) in Complex with PD4 (LR4-23)
To Be Published
7M9L
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BU of 7m9l by Molmil
HIV-1 Protease WT (NL4-3) in Complex with LR4-15
Descriptor: Protease, SULFATE ION, diethyl [(4-{(2S,3R)-4-[(2-ethylbutyl){4-[(1S)-1-hydroxyethyl]benzene-1-sulfonyl}amino]-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate
Authors:Lockbaum, G.J, Schiffer, C.A.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:HIV-1 Protease WT (NL4-3) in Complex with LR4-15
To Be Published

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PDB entries from 2024-03-27

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