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5MDU
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BU of 5mdu by Molmil
Structure of the RNA recognition motif (RRM) of Seb1 from S. pombe.
Descriptor: CHLORIDE ION, GLYCEROL, Rpb7-binding protein seb1, ...
Authors:Wittmann, S, Renner, M, El Omari, K, Adams, O, Vasiljeva, L, Grimes, J.
Deposit date:2016-11-13
Release date:2017-04-12
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.
Nat Commun, 8, 2017
5W0G
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BU of 5w0g by Molmil
Structure of U2AF65 (U2AF2) RRM1 at 1.07 resolution
Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, Splicing factor U2AF 65 kDa subunit, ...
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2017-05-30
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.
Biochemistry, 56, 2017
7ZUG
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BU of 7zug by Molmil
Heterogeneous nuclear ribonucleoprotein H1, qRRM2 domain
Descriptor: CHLORIDE ION, Heterogeneous nuclear ribonucleoprotein H, N-terminally processed, ...
Authors:Winter, N, Kumar, M, Isupov, M.N, Wiener, R.
Deposit date:2022-05-12
Release date:2023-05-24
Method:X-RAY DIFFRACTION (1.075 Å)
Cite:Heterogeneous nuclear ribonucleoprotein H1, qRRM2 domain
To Be Published
1L3K
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BU of 1l3k by Molmil
UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1
Descriptor: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1
Authors:Vitali, J, Ding, J, Jiang, J, Zhang, Y, Krainer, A.R, Xu, R.-M.
Deposit date:2002-02-27
Release date:2002-04-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.
Nucleic Acids Res., 30, 2002
5W0H
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BU of 5w0h by Molmil
Structure of U2AF65 (U2AF2) RRM2 at 1.11 Angstrom Resolution
Descriptor: Splicing factor U2AF 65 kDa subunit
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2017-05-30
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.
Biochemistry, 56, 2017
6N3D
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BU of 6n3d by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6HIP
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BU of 6hip by Molmil
Structure of SPF45 UHM bound to HIV-1 Rev ULM
Descriptor: HIV-1 Rev (41-49), SODIUM ION, Splicing factor 45, ...
Authors:Pabis, M, Corsini, L, Sattler, M.
Deposit date:2018-08-30
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
Nucleic Acids Res., 47, 2019
3NS6
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BU of 3ns6 by Molmil
Crystal structure of hte RNA recognition motif of yeast eIF3b residues 76-170
Descriptor: Eukaryotic translation initiation factor 3 subunit B, SULFATE ION
Authors:Khoshnevis, S, Neumann, P, Ficner, R.
Deposit date:2010-07-01
Release date:2010-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.
Plos One, 5, 2010
5D78
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BU of 5d78 by Molmil
Structure of RRM3 Domain of Mip6 at 1.25 A Resolution
Descriptor: BETA-MERCAPTOETHANOL, RNA-binding protein MIP6, SULFATE ION
Authors:Mohamad, N, Bravo, J.
Deposit date:2015-08-13
Release date:2016-08-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.251 Å)
Cite:Structure of RRM3 Domain of Mip6 at 1.25 A Resolution
To Be Published
4YUD
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BU of 4yud by Molmil
Crystal structure of a RNA binding motif protein 39 (RBM39) from Homo sapiens at 1.28 A resolution
Descriptor: RNA-binding protein 39
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2015-03-18
Release date:2015-04-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Crystal structure of a RNA binding motif protein 39 (RBM39) from Homo sapiens at 1.28 A resolution
To be published
3S8S
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BU of 3s8s by Molmil
Crystal structure of the RRM domain of human SETD1A
Descriptor: Histone-lysine N-methyltransferase SETD1A, UNKNOWN ATOM OR ION
Authors:Chao, X, Tempel, W, Bian, C, Cerovina, T, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2011-05-30
Release date:2011-06-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the RRM domain of human SETD1A
to be published
5D77
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BU of 5d77 by Molmil
Structure of Mip6 RRM3 Domain
Descriptor: CITRIC ACID, NITRATE ION, RNA-binding protein MIP6, ...
Authors:Mohamad, N, Bravo, J.
Deposit date:2015-08-13
Release date:2016-08-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of Mip6 RRM3 domain at 1.3
To Be Published
2XNQ
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BU of 2xnq by Molmil
Structural insights into cis element recognition of non- polyadenylated RNAs by the Nab3-RRM
Descriptor: ACETATE ION, NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 3
Authors:Lunde, B.M, Horner, M, Meinhart, A.
Deposit date:2010-08-05
Release date:2010-09-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural Insights Into Cis Element Recognition of Non-Polyadenylated Rnas by the Nab3-Rrm.
Nucleic Acids Res., 39, 2011
6FQ1
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BU of 6fq1 by Molmil
Crystal structure of the RRM12 domain of IMP3
Descriptor: 1,2-ETHANEDIOL, Insulin-like growth factor 2 mRNA-binding protein 3
Authors:Jia, M, Gut, H, Chao, A.J.
Deposit date:2018-02-12
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Structural basis of IMP3 RRM12 recognition of RNA.
RNA, 24, 2018
6GD3
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BU of 6gd3 by Molmil
Structure of HuR RRM3 in complex with RNA (UAUUUA)
Descriptor: ELAV-like protein 1, RNA (5'-R(P*UP*AP*UP*UP*UP*A)-3'), SODIUM ION
Authors:Pabis, M, Sattler, M.
Deposit date:2018-04-21
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.
Nucleic Acids Res., 47, 2019
2XS2
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BU of 2xs2 by Molmil
Crystal structure of the RRM domain of mouse Deleted in azoospermia-like in complex with RNA, UUGUUCUU
Descriptor: 5'-R(*UP*UP*GP*UP*UP*CP*UP*U)-3', DELETED IN AZOOSPERMIA-LIKE, ZINC ION
Authors:Jenkins, H.T, Edwards, T.A.
Deposit date:2010-09-24
Release date:2011-10-05
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.
Proc. Natl. Acad. Sci. U.S.A., 108, 2011
6XLV
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BU of 6xlv by Molmil
Crystal structure of leukemia-associated N196K mutant of U2AF65 bound to AdML splice site
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
7MI2
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BU of 7mi2 by Molmil
Seb1-G476S RNA binding domain
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Rpb7-binding protein seb1
Authors:Jacewicz, A, Shuman, S.
Deposit date:2021-04-16
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.
Proc.Natl.Acad.Sci.USA, 118, 2021
6F4J
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BU of 6f4j by Molmil
Crystal structure of Drosophila melanogaster SNF/U2A' complex
Descriptor: POLYETHYLENE GLYCOL (N=34), Probable U2 small nuclear ribonucleoprotein A', SULFATE ION, ...
Authors:Weber, G, DeKoster, G, Holton, N, Hall, K.B, Wahl, M.C.
Deposit date:2017-11-29
Release date:2018-06-20
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.
Nat Commun, 9, 2018
2XS7
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BU of 2xs7 by Molmil
Crystal structure of the RRM domain of mouse Deleted in azoospermia- like in complex with Sycp3 RNA, UUGUUU
Descriptor: 5'-R(*UP*UP*GP*UP*UP*UP)-3', DELETED IN AZOOSPERMIA-LIKE, ZINC ION
Authors:Jenkins, H.T, Edwards, T.A.
Deposit date:2010-09-24
Release date:2011-10-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Kinked Beta-Strands Mediate High-Affinity Recognition of Mrna Targets by the Germ-Cell Regulator Dazl
Proc.Natl.Acad.Sci.USA, 108, 2011
2HZC
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BU of 2hzc by Molmil
Crystal structure of the N-terminal RRM of the U2AF large subunit
Descriptor: HEXAETHYLENE GLYCOL, Splicing factor U2AF 65 kDa subunit, ZINC ION
Authors:Thickman, K.R, Sickmier, E.A, Kielkopf, C.L.
Deposit date:2006-08-08
Release date:2006-08-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif.
J.Mol.Biol., 366, 2007
7S3A
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BU of 7s3a by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-C5 oligonucleotide
Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*CP*U)-D(P*(BRU))-R(P*CP*C)-3'), SODIUM ION, Splicing factor U2AF 65 kDa subunit
Authors:Jenkins, J.L, Henderson, S, Kielkopf, C.L.
Deposit date:2021-09-05
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
6F4I
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BU of 6f4i by Molmil
Crystal structure of Drosophila melanogaster SNF
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Weber, G, Holton, N, Hall, K.B, DeKoster, G, Wahl, M.C.
Deposit date:2017-11-29
Release date:2018-06-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.
Nat Commun, 9, 2018
6XLW
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BU of 6xlw by Molmil
Crystal structure of U2AF65 bound to AdML splice site sequence
Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ...
Authors:Maji, D, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2020-06-29
Release date:2020-10-07
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
J.Biol.Chem., 295, 2020
5EV3
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BU of 5ev3 by Molmil
Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016

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PDB entries from 2024-03-27

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