1AYP
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A PROBE MOLECULE COMPOSED OF SEVENTEEN PERCENT OF TOTAL DIFFRACTING MATTER GIVES CORRECT SOLUTIONS IN MOLECULAR REPLACEMENT
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4) COMPLEXED WITH AN ACYLAMINO PHOSPHOLIPID ANALOGUE
Authors:Oh, B.-H.
Deposit date:1994-07-19
Release date:1995-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:A probe molecule composed of seventeen percent of total diffracting matter gives correct solutions in molecular replacement.
Acta Crystallogr.,Sect.D, 51, 1995
1BBC
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STRUCTURE OF RECOMBINANT HUMAN RHEUMATOID ARTHRITIC SYNOVIAL FLUID PHOSPHOLIPASE A2 AT 2.2 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2 (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE) (E.C.3.1.1.4)
Authors:Wery, J.-P., Schevitz, R.W., Clawson, D.K., Bobbitt, J.L., Dow, E.R., Gamboa, G., Goodsonjunior, T., Hermann, R.B., Kramer, R.M., Mcclure, D.B., Mihelich, E.D., Putnam, J.E., Sharp, J.D., Stark, D.H., Teater, C., Warrick, M.W., Jones, N.D.
Deposit date:1992-05-04
Release date:1993-10-31
Modification date:2012-02-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution.
Nature, 352, 1991
1BP2
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STRUCTURE OF BOVINE PANCREATIC PHOSPHOLIPASE A2 AT 1.7 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4) (PHOSPHATIDE ACYL-HYDROLASE)
Authors:Dijkstra, B.W., Kalk, K.H., Hol, W.G.J., Drenth, J.
Deposit date:1981-04-06
Release date:1981-05-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of bovine pancreatic phospholipase A2 at 1.7A resolution.
J.Mol.Biol., 147, 1981
1BPQ
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PHOSPHOLIPASE A2 ENGINEERING. X-RAY STRUCTURAL AND FUNCTIONAL EVIDENCE FOR THE INTERACTION OF LYSINE-56 WITH SUBSTRATES
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4) MUTANT WITH LYS 56 REPLACED BY MET (K56M)
Authors:Sundaralingam, M.
Deposit date:1991-10-28
Release date:1993-10-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates.
Biochemistry, 30, 1991
1BVM
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SOLUTION NMR STRUCTURE OF BOVINE PANCREATIC PHOSPHOLIPASE A2, 20 STRUCTURES
Descriptor:PROTEIN (PHOSPHOLIPASE A2) (3.1.1.4)
Authors:Yuan, C.-H., Byeon, I.-J.L., Li, Y., Tsai, M.-D.
Deposit date:1998-09-14
Release date:1999-09-16
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural analysis of phospholipase A2 from functional perspective. 1. Functionally relevant solution structure and roles of the hydrogen-bonding network.
Biochemistry, 38, 1999
1C74
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STRUCTURE OF THE DOUBLE MUTANT (K53,56M) OF PHOSPHOLIPASE A2
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Sekar, K., Tsai, M.D., Jain, M.K., Ramakumar, S.
Deposit date:2000-01-22
Release date:2000-07-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of the anionic interface preference and k*cat activation of pancreatic phospholipase A2.
Biochemistry, 39, 2000
1CEH
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STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER
Descriptor:PHOSPHOLIPASE A2 (PLA2) (E.C.3.1.1.4) MUTANT WITH ASP 99 REPLACED BY ASN (D99N)
Authors:Kumar, A., Sekharudu, C., Ramakrishnan, B., Dupureur, C.M., Zhu, H., Tsai, M.-D., Sundaralingam, M.
Deposit date:1994-11-16
Release date:1995-02-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.
Protein Sci., 3, 1994
1DB4
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HUMAN S-PLA2 IN COMPLEX WITH INDOLE 8
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Chirgadze, N.Y., Schevitz, R.W., Wery, J.-P.
Deposit date:1999-11-02
Release date:1999-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.
Nat.Struct.Biol., 2, 1995
1DB5
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HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Chirgadze, N.Y., Schevitz, R.W., Wery, J.-P.
Deposit date:1999-11-02
Release date:1999-11-12
Modification date:2012-02-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.
Nat.Struct.Biol., 2, 1995
1DCY
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CRYSTAL STRUCTURE OF HUMAN S-PLA2 IN COMPLEX WITH INDOLE 3 ACTIVE SITE INHIBITOR
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Chirgadze, N.Y., Schevitz, R.W., Wery, J.-P.
Deposit date:1999-11-05
Release date:1999-11-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.
Nat.Struct.Biol., 2, 1995
1FDK
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CARBOXYLIC ESTER HYDROLASE (PLA2-MJ33 INHIBITOR COMPLEX)
Descriptor:PHOSPHOLIPASE A2, 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL
Authors:Sundaralingam, M.
Deposit date:1997-09-04
Release date:1998-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,.
Biochemistry, 36, 1997
1FX9
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CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + SULPHATE IONS)
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Pan, Y.H., Epstein, T.M., Jain, M.K., Bahnson, B.J.
Deposit date:2000-09-25
Release date:2001-09-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry, 40, 2001
1FXF
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CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + PHOSPHATE IONS)
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Pan, Y.H., Epstein, T.M., Jain, M.K., Bahnson, B.J.
Deposit date:2000-09-25
Release date:2001-09-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
Biochemistry, 40, 2001
1G4I
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CRYSTAL STRUCTURE OF THE BOVINE PANCREATIC PHOSPHOLIPASE A2 AT 0.97A
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Steiner, R.A., Rozeboom, H.J., de Vries, A., Kalk, K.H., Murshudov, G.N., Wilson, K.S., Dijkstra, B.W.
Deposit date:2000-10-27
Release date:2001-04-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:X-ray structure of bovine pancreatic phospholipase A2 at atomic resolution.
Acta Crystallogr.,Sect.D, 57, 2001
1GH4
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STRUCTURE OF THE TRIPLE MUTANT (K56M, K120M, K121M) OF PHOSPHOLIPASE A2
Descriptor:PHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Sekar, K., Velmurugan, D., Tsai, M.D.
Deposit date:2000-11-09
Release date:2001-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2.
J.Mol.Biol., 324, 2002
1HN4
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PROPHOSPHOLIPASE A2 DIMER COMPLEXED WITH MJ33, SULFATE, AND CALCIUM
Descriptor:PROPHOSPHOLIPASE A2 (E.C.3.1.1.4)
Authors:Epstein, T.M., Pan, Y.H., Jain, M.K., Bahnson, B.J.
Deposit date:2000-12-06
Release date:2001-12-05
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure.
Biochemistry, 40, 2001
1IRB
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CARBOXYLIC ESTER HYDROLASE
Descriptor:PHOSPHOLIPASE A2
Authors:Sundaralingam, M.
Deposit date:1997-08-13
Release date:1997-12-24
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
Biochemistry, 35, 1996
1J1A
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PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIA) WITH ANTI-INFLAMMATORY ACTIVITY
Descriptor:Phospholipase A2 (E.C.3.1.1.4)
Authors:Hansford, K.A., Reid, R.C., Clark, C.I., Tyndall, J.D.A., Whitehouse, M.W., Guthrie, T., McGeary, R.P., Schafer, K., Martin, J.L., Fairlie, D.P.
Deposit date:2002-12-03
Release date:2003-03-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:D-Tyrosine as a Chiral Precusor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A2 (IIa) with Antiinflammatory Activity
Chembiochem, 4, 2003
1KQU
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HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A SUBSTRATE ANOLOGUE
Descriptor:Phospholipase A2, membrane associated (E.C.3.1.1.4)
Authors:Tyndall, J.D., Martin, J.L.
Deposit date:2002-01-07
Release date:2003-11-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity.
Chembiochem, 4, 2003
1KVO
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HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE
Descriptor:HUMAN PHOSPHOLIPASE A2, 4-(S)-[(1-OXO-7-PHENYLHEPTYL)AMINO]-5-[4-(PHENYLMETHYL)PHENYLTHIO]PENTANOIC ACID
Authors:Cha, S.-S., Abdel-Meguid, S.S., Oh, B.-H.
Deposit date:1996-07-29
Release date:1997-07-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX).
J.Med.Chem., 39, 1996
1KVW
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CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT H48Q OF BOVINE PANCREATIC PLA2 ENZYME
Descriptor:PHOSPHOLIPASE A2
Authors:Sundaralingam, M.
Deposit date:1998-04-24
Release date:1998-11-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1KVX
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CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT D99A OF BOVINE PANCREATIC PLA2, 1.9 A ORTHORHOMBIC FORM
Descriptor:PHOSPHOLIPASE A2
Authors:Sundaralingam, M.
Deposit date:1998-04-28
Release date:1998-11-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1KVY
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CARBOXYLIC ESTER HYDROLASE, SINGLE MUTANT D49E COORDINATED TO CALCIUM
Descriptor:PHOSPHOLIPASE A2
Authors:Sundaralingam, M.
Deposit date:1998-04-29
Release date:1998-11-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2.
Acta Crystallogr.,Sect.D, 55, 1999
1L8S
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CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + LPC-ETHER + ACETATE + PHOSPHATE IONS)
Descriptor:PHOSPHOLIPASE A2, MAJOR ISOENZYME (E.C.3.1.1.4)
Authors:Pan, Y.H., Bahnson, B.J.
Deposit date:2002-03-21
Release date:2002-12-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of phospholipase A2 Complex with the Hydrolysis Products of Platelet Activating Factor: Equilibrium Binding of Fatty Acid and Lysophospholipid-ether at the Active Site may be Mutually Exclusive
Biochemistry, 41, 2002
1LE6
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CARBOXYLIC ESTER HYDROLASE, P 1 21 1 SPACE GROUP
Descriptor:Group X Secretory Phospholipase A2 (E.C.3.1.1.4)
Authors:Pan, Y.H., Jain, M.K., Bahnson, B.J.
Deposit date:2002-04-09
Release date:2002-08-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
J.Biol.Chem., 277, 2002
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