PDB: 522 resultsInfo pagesStatus searchChemie searchBIRD

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8KDX	Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current Descriptor: Microtubule-associated protein tau, Tyrosine-protein kinase Fyn Authors: Padavattan, S, Jos, S. Deposit date: 2023-08-10 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (1.01 Å) Cite: Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current. J.Mol.Biol., 436, 2024
8WEJ	Structure of human phagocyte NADPH oxidase in the activated state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7D5 Fab heavy chain, 7D5 Fab light chain, ... Authors: Chen, L, Liu, X. Deposit date: 2023-09-18 Release date: 2024-01-24 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: Structure of human phagocyte NADPH oxidase in the activated state. Nature, 627, 2024
8XN8	The Crystal Structure of SRC from Biortus. Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... Authors: Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. Deposit date: 2023-12-29 Release date: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The Crystal Structure of SRC from Biortus. To Be Published
8WFF	The Crystal Structure of LYN from Biortus. Descriptor: CHLORIDE ION, CITRATE ANION, Tyrosine-protein kinase Lyn Authors: Wang, F, Cheng, W, Yuan, Z, Qi, J, Lu, Y. Deposit date: 2023-09-19 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The Crystal Structure of LYN from Biortus. To Be Published
8SSN	Abl kinase in complex with SKI and asciminib Descriptor: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Ludewig, H, Kim, C, Kern, D. Deposit date: 2023-05-08 Release date: 2023-09-06 Method: X-RAY DIFFRACTION (2.86 Å) Cite: A biophysical framework for double-drugging kinases. Proc.Natl.Acad.Sci.USA, 120, 2023
8GMB	Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) Descriptor: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK Authors: Lin, D.Y, Andreotti, A.H. Deposit date: 2023-03-24 Release date: 2023-08-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
7YQE	Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54. Descriptor: Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor Authors: Song, G, Xu, S. Deposit date: 2022-08-06 Release date: 2023-08-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun, 15, 2024
8DGO	Growth Factor Receptor-Bound Protein 2 (Grb2) bound to phosphorylated PEAK3 (pY24) peptide Descriptor: Growth factor receptor bound protein 2, Phosphorylated PEAK3 (pY24) peptide Authors: Roy, M.J, Hardy, J.M, Lucet, I.S. Deposit date: 2022-06-24 Release date: 2023-06-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8IAH	Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State I, Global map Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... Authors: Li, N, Chen, S, Gao, N. Deposit date: 2023-02-08 Release date: 2023-05-03 Last modified: 2023-05-10 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis of membrane skeleton organization in red blood cells. Cell, 186, 2023
8CF4	SH3 domain solved by the exact solid-state method from the Bruker Dynamics Center using the combined correction method with PDB 2NUZ Descriptor: Spectrin alpha chain, non-erythrocytic 1 Authors: Soeldner, B. Deposit date: 2023-02-02 Release date: 2023-03-08 Method: SOLID-STATE NMR Cite: Integrated Assessment of the Structure and Dynamics of Solid Proteins. J Phys Chem Lett, 14, 2023
8CHH	SH3 domain solved by the exact solid-state method from the Bruker Dynamics Center using the correction method for spin-diffusion with PDB 2NUZ as reference Descriptor: Spectrin alpha chain, non-erythrocytic 1 Authors: Soeldner, B. Deposit date: 2023-02-08 Release date: 2023-03-08 Method: SOLID-STATE NMR Cite: Integrated Assessment of the Structure and Dynamics of Solid Proteins. J Phys Chem Lett, 14, 2023
8CHG	SH3 domain solved by the exact solid-state method from the Bruker Dynamics Center using the correction for dipolar truncation with PDB 2NUZ Descriptor: Spectrin alpha chain, non-erythrocytic 1 Authors: Soeldner, B. Deposit date: 2023-02-08 Release date: 2023-03-08 Method: SOLID-STATE NMR Cite: Integrated Assessment of the Structure and Dynamics of Solid Proteins. J Phys Chem Lett, 14, 2023
8F2P	Nef SF2 dimerization mutant bound to Hck SH3 Descriptor: C-terminal core protein, Tyrosine-protein kinase HCK Authors: Thomas, C.E, Alvarado, J.J, Smithgall, T.E. Deposit date: 2022-11-08 Release date: 2023-02-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers. J.Mol.Biol., 435, 2023
7UD6	Designed Enzyme SH3-588 (Catechol O-methyltransferase catalytic domain and Src homology 3 binding domain fusion) Descriptor: POTASSIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Tyrosine-protein kinase Fyn,Catechol O-methyltransferase Authors: Ongpipattanakul, C, Nair, S.K. Deposit date: 2022-03-18 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Designer installation of a substrate recruitment domain to tailor enzyme specificity. Nat.Chem.Biol., 19, 2023
7UY0	Crystal structure of human Fgr tyrosine kinase in complex with A-419259 Descriptor: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... Authors: Du, S, Alvarado, J.J, Smithgall, T.E. Deposit date: 2022-05-06 Release date: 2022-12-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.55 Å) Cite: ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
7UY3	Crystal structure of human Fgr tyrosine kinase in complex with TL02-59 Descriptor: 1,2-ETHANEDIOL, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ... Authors: Du, S, Alvarado, J.J, Smithgall, T.E. Deposit date: 2022-05-06 Release date: 2022-12-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.99 Å) Cite: ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
7T8T	CryoEM structure of PLCg1 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION Authors: Endo-Streeter, S, Sondek, J. Deposit date: 2021-12-17 Release date: 2022-12-21 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: CryoEM structure of PLCg1 To Be Published
7PVZ	Crystal structure of the intertwined dimer of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant Descriptor: Isoform 2 of Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published
8DGQ	Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide Descriptor: MALONATE ION, Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 Authors: Stiegler, A.L, Vish, K.J, Boggon, T.J. Deposit date: 2022-06-24 Release date: 2022-11-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP. Structure, 30, 2022
7PVX	Crystal structure of the c-Src SH3 domain mutant E93V-S94A-R95S-T96G-N112G-N113Y-T114N-E115H in complex with the synthetic peptide VSL12 Descriptor: Isoform 1 of Proto-oncogene tyrosine-protein kinase Src, VSL12 peptide Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of the c-Src SH3 domain mutants of the specificity region in complex with polyproline peptides To be published
7PVQ	Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in the space group P21221 Descriptor: Tyrosine-protein kinase ABL1 Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.55 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published
7PVS	Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in presence of PEG 200 Descriptor: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, SODIUM ION, ... Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published
7PW2	Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E mutant Descriptor: Non-specific protein-tyrosine kinase Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.1 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published
7PVY	Crystal structure of the c-Src SH3 domain E93V-S94A-R95S-T96G mutant Descriptor: Isoform 2 of Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published
7PVR	Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in the space group P41 Descriptor: Tyrosine-protein kinase ABL1 Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2021-10-05 Release date: 2022-09-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: The effect of the hinge loops composition in the domain swapping of the SH3 domain To be published

 

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