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5GJI
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BU of 5gji by Molmil
PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex
Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ...
Authors:Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M.
Deposit date:2016-06-30
Release date:2016-12-14
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
1LKK
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BU of 1lkk by Molmil
HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE)
Descriptor: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE
Authors:Tong, L.
Deposit date:1995-11-10
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution.
J.Mol.Biol., 256, 1996
5AUL
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BU of 5aul by Molmil
PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex
Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28
Authors:Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N.
Deposit date:2015-04-28
Release date:2016-05-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
1D4T
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BU of 1d4t by Molmil
CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor: SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP
Authors:Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
7CIO
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BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
Descriptor: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2020-07-08
Release date:2020-12-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
7RNS
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BU of 7rns by Molmil
nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53
Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ...
Authors:Dai, S, Horton, J.R, Cheng, X.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin
To Be Published
6ICG
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BU of 6icg by Molmil
Grb2 SH2 domain in phosphopeptide free form
Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION
Authors:Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2018-09-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Biophys Physicobio., 16, 2019
5GJH
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BU of 5gjh by Molmil
Gads SH2 domain/CD28-derived peptide complex
Descriptor: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28
Authors:Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M.
Deposit date:2016-06-30
Release date:2016-12-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
4EIH
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BU of 4eih by Molmil
Crystal structure of Arg SH2 domain
Descriptor: Abelson tyrosine-protein kinase 2, CHLORIDE ION
Authors:Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J.
Deposit date:2012-04-05
Release date:2013-04-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin.
J.Biol.Chem., 289, 2014
7T1K
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BU of 7t1k by Molmil
Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ...
Authors:Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
3EAZ
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BU of 3eaz by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant.
Descriptor: Tyrosine-protein kinase CSK
Authors:Liu, D, Seidel, R.D, Cowburn, D.
Deposit date:2008-08-26
Release date:2009-11-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
7T1L
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BU of 7t1l by Molmil
Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide
Descriptor: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ...
Authors:Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
3WA4
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BU of 3wa4 by Molmil
Grb2 SH2 domain/CD28-derived peptide complex
Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ...
Authors:Higo, K, Oda, M, Ito, N.
Deposit date:2013-04-23
Release date:2014-02-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28
Plos One, 8, 2013
6KC4
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BU of 6kc4 by Molmil
Crystal structure of human Fer SH2 domain bound to a phosphopeptide (DEpYENVD)
Descriptor: Tyrosine-protein kinase Fer, phosphopeptide (EDpYENVD)
Authors:Matsuura, Y.
Deposit date:2019-06-27
Release date:2019-09-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase.
Protein Sci., 28, 2019
3EAC
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BU of 3eac by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form.
Descriptor: Tyrosine-protein kinase CSK
Authors:Liu, D, Seidel, R.D, Cowburn, D.
Deposit date:2008-08-25
Release date:2009-11-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
5W3R
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BU of 5w3r by Molmil
SH2B1 SH2 Domain
Descriptor: PHENOL, PHOSPHATE ION, SH2B adapter protein 1
Authors:McKercher, M.A, Wuttke, D.S.
Deposit date:2017-06-08
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.386 Å)
Cite:Diversity in peptide recognition by the SH2 domain of SH2B1.
Proteins, 86, 2018
1D1Z
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BU of 1d1z by Molmil
CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor: SAP SH2 DOMAIN, SULFATE ION
Authors:Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
8X2P
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BU of 8x2p by Molmil
The Crystal Structure of LCK from Biortus.
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, TETRAETHYLENE GLYCOL, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y.
Deposit date:2023-11-10
Release date:2023-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of LCK from Biortus.
To Be Published
5TNW
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BU of 5tnw by Molmil
Phospholipase C gamma-1 C-terminal SH2 domain
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Authors:Wuttke, D.S, McKercher, M.A.
Deposit date:2016-10-14
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein.
Biochemistry, 56, 2017
4U1P
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BU of 4u1p by Molmil
Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
Descriptor: Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ...
Authors:Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J.
Deposit date:2014-07-16
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
To Be Published
2VIF
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BU of 2vif by Molmil
Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide
Descriptor: 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6
Authors:Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S.
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase.
J.Biol.Chem., 286, 2011
7RNU
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BU of 7rnu by Molmil
nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53
Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ...
Authors:Dai, S, Horton, J.R, Cheng, X.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin
To Be Published
2CIA
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BU of 2cia by Molmil
human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOPLASMIC PROTEIN NCK2, ISOPROPYL ALCOHOL, ...
Authors:Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W.
Deposit date:2006-03-17
Release date:2006-04-24
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains.
J.Biol.Chem., 281, 2006
5DC4
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BU of 5dc4 by Molmil
CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A
Descriptor: AS25 monobody, GLYCEROL, Tyrosine-protein kinase ABL1
Authors:Wojcik, J.B, Koide, A, Koide, S.
Deposit date:2015-08-23
Release date:2016-03-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface.
J.Biol.Chem., 291, 2016
5TQ1
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BU of 5tq1 by Molmil
Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Insulin receptor
Authors:Wuttke, D.S, McKercher, M.A.
Deposit date:2016-10-21
Release date:2017-04-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.485 Å)
Cite:Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein.
Biochemistry, 56, 2017

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