1A07
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-09
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A08
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-09
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A09
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1A
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C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Modification date:2011-08-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1B
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1C
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))
Descriptor:C-SRC TYROSINE KINASE, ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1E
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1AB2
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL
Descriptor:PROTO-ONCOGENE TYROSINE KINASE (E.C.2.7.1.112) (SRC HOMOLOGY 2 DOMAIN) ("ABELSON", SH2 ABL) (NMR, 20 STRUCTURES)
Authors:Overduin, M., Rios, C.B., Mayer, B.J., Baltimore, D., Cowburn, D.
Deposit date:1993-07-19
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the src homology 2 domain of c-abl.
Cell(Cambridge,Mass.), 70, 1992
1AOT
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NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE
Descriptor:FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D., Shaw, G.L., Morton, C.J., Day, A.J., Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
1AOU
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NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES
Descriptor:FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D., Shaw, G.L., Morton, C.J., Day, A.J., Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
1AYA
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (PTP1D, SHPTP2) (E.C.3.1.3.48) COMPLEXED WITH THE PEPTIDE PDGFR-1009
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1AYB
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (PTP1D, SHPTP2) (E.C.3.1.3.48) COMPLEXED WITH THE PEPTIDE IRS-1-895
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1AYD
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CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE
Descriptor:TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (PTP1D, SHPTP2) (E.C.3.1.3.48)
Authors:Lee, C.-H., Kuriyan, J.
Deposit date:1994-05-15
Release date:1994-08-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2, 1994
1BFI
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SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES
Descriptor:P85 ALPHA
Authors:Siegal, G., Davis, B., Kristensen, S.M., Sankar, A., Linacre, J., Stein, R.C., Panayotou, G., Waterfield, M.D., Driscoll, P.C.
Deposit date:1997-11-18
Release date:1998-02-25
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
1BFJ
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SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:P85 ALPHA
Authors:Siegal, G., Davis, B., Kristensen, S.M., Sankar, A., Linacre, J., Stein, R.C., Panayotou, G., Waterfield, M.D., Driscoll, P.C.
Deposit date:1997-11-18
Release date:1998-02-25
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
1BHF
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P56LCK SH2 DOMAIN INHIBITOR COMPLEX
Descriptor:T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK, INHIBITOR ACE-IPA-GLU-GLU-ILE
Authors:Tong, L., Warren, T.C., Lukas, S., Schembri-King, J., Betageri, R., Proudfoot, J.R., Jakes, S.
Deposit date:1998-06-08
Release date:1998-10-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
1BLJ
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NMR ENSEMBLE OF BLK SH2 DOMAIN, 20 STRUCTURES
Descriptor:P55 BLK PROTEIN TYROSINE KINASE
Authors:Metzler, W.J., Leiting, B., Pryor, K., Mueller, L., Farmer II, B.T.
Deposit date:1996-03-26
Release date:1997-03-12
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
1BLK
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NMR ENSEMBLE OF BLK SH2 DOMAIN USING CHEMICAL SHIFT REFINEMENT, 20 STRUCTURES
Descriptor:P55 BLK PROTEIN TYROSINE KINASE
Authors:Metzler, W.J., Leiting, B., Pryor, K., Mueller, L., Farmer II, B.T.
Deposit date:1996-03-26
Release date:1997-03-12
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
1CJ1
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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
Descriptor:GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
Authors:Rahuel, J.
Deposit date:1999-04-21
Release date:1999-12-22
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
J.Med.Chem., 42, 1999
1CSY
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SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor:SYK PROTEIN TYROSINE KINASE, ACETYL-THR-PTR-GLU-THR-LEU-NH2
Authors:Narula, S.S., Yuan, R.W., Adams, S.E., Green, O.M., Green, J., Phillips, T.B., Zydowsky, L.D., Botfield, M.C., Hatada, M.H., Laird, E.R., Zoller, M.J., Karas, J.L., Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Modification date:2012-02-22
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1CSZ
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SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR
Descriptor:SYK PROTEIN TYROSINE KINASE, ACETYL-THR-PTR-GLU-THR-LEU-NH2
Authors:Narula, S.S., Yuan, R.W., Adams, S.E., Green, O.M., Green, J., Phillips, T.B., Zydowsky, L.D., Botfield, M.C., Hatada, M.H., Laird, E.R., Zoller, M.J., Karas, J.L., Dalgarno, D.C.
Deposit date:1995-10-03
Release date:1996-11-08
Modification date:2012-02-22
Method:SOLUTION NMR
Cite:Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Structure, 3, 1995
1CWD
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HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor:P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE PRO-GLU-GLY-ASP-PMP-GLU-GLU-VAL-LEU, WHERE PMP IS (PHOSPHONOMETHYL)PHENYLALANINE, PHOSPHONOMETHYL GROUP
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
1CWE
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HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE
Descriptor:P56LCK TYROSINE KINASE, PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO WHERE ACQ IS N-ACETYL GLUTAMINE AND PMP IS (PHOSPHONOMETHYL)PHENYLALANINE, PHOSPHONOMETHYL GROUP
Authors:Mikol, V.
Deposit date:1995-09-06
Release date:1996-12-07
Modification date:2011-08-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
J.Mol.Biol., 246, 1995
1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
Descriptor:SAP SH2 DOMAIN
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-09-22
Release date:1999-10-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
Descriptor:T CELL SIGNAL TRANSDUCTION MOLECULE SAP + SLAM CYTOPLAMIC TAIL PEPTIDE
Authors:Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
Deposit date:1999-10-06
Release date:1999-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
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