1A3P
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ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES
Descriptor:EPIDERMAL GROWTH FACTOR
Authors:Barnham, K., Torres, A., Alewood, D., Alewood, P., Domagala, T., Nice, E., Norton, R.
Deposit date:1998-01-22
Release date:1998-07-29
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Protein Sci., 7, 1998
1EGF
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SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS
Descriptor:EPIDERMAL GROWTH FACTOR (EGF) (NMR, 16 STRUCTURES)
Authors:Montelione, G.T., Wuthrich, K., Scheraga, H.A.
Deposit date:1991-10-01
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints.
Biochemistry, 31, 1992
1EPG
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THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
Descriptor:EPIDERMAL GROWTH FACTOR (EGF) IN PH 2 SOLUTION (NMR, MINIMIZED MEAN STRUCTURE)
Authors:Kohda, D., Inagaki, F.
Deposit date:1992-03-24
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions.
Biochemistry, 31, 1992
1EPH
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THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
Descriptor:EPIDERMAL GROWTH FACTOR (EGF) IN PH 2 SOLUTION (NMR, 10 STRUCTURES)
Authors:Kohda, D., Inagaki, F.
Deposit date:1992-03-24
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions.
Biochemistry, 31, 1992
1EPI
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THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
Descriptor:EPIDERMAL GROWTH FACTOR (EGF) IN PH 6.8 SOLUTION (NMR, MINIMIZED MEAN STRUCTURE)
Authors:Kohda, D., Inagaki, F.
Deposit date:1992-03-24
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions.
Biochemistry, 31, 1992
1EPJ
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THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
Descriptor:EPIDERMAL GROWTH FACTOR (EGF) IN PH 6.8 SOLUTION (NMR, 5 STRUCTURES)
Authors:Kohda, D., Inagaki, F.
Deposit date:1992-03-24
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions.
Biochemistry, 31, 1992
1GK5
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SOLUTION STRUCTURE THE MEGF/TGFALPHA44-50 CHIMERIC GROWTH FACTOR
Descriptor:MEGF/TGFALPHA44-50 CHIMERA
Authors:Chamberlin, S.G., Brennan, L., Puddicombe, S.M., Davies, D.E., Turner, D.L.
Deposit date:2001-08-08
Release date:2002-08-08
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of the Megf/Tgfalpha44-50 Chimeric Growth Factor.
Eur.J.Biochem., 268, 2001
1JL9
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CRYSTAL STRUCTURE OF HUMAN EPIDERMAL GROWTH FACTOR
Descriptor:EPIDERMAL GROWTH FACTOR
Authors:Lu, H.S., Chai, J.J., Li, M., Huang, B.R., He, C.H., Bi, R.C.
Deposit date:2001-07-16
Release date:2001-10-24
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human epidermal growth factor and its dimerization
J.Biol.Chem., 276, 2001
1P9J
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SOLUTION STRUCTURE AND DYNAMICS OF THE EGF/TGF-ALPHA CHIMERA T1E
Descriptor:chimera of Epidermal growth factor(EGF) and Transforming growth factor alpha (TGF-alpha)
Authors:Wingens, M., Walma, T., Van Ingen, H., Stortelers, C., Van Leeuwen, J.E., Van Zoelen, E.J., Vuister, G.W.
Deposit date:2003-05-12
Release date:2003-10-07
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural Analysis of an Epidermal Growth Factor/Transforming Growth Factor-alpha Chimera with Unique ErbB Binding Specificity.
J.Biol.Chem., 278, 2003
1XDT
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COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR
Descriptor:DIPHTHERIA TOXIN, HEPARIN-BINDING EPIDERMAL GROWTH FACTOR
Authors:Louie, G.V., Yang, W., Bowman, M.E., Choe, S.
Deposit date:1997-11-18
Release date:1998-02-25
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.
Mol.Cell, 1, 1997
2KV4
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EGF
Descriptor:Epidermal growth factor
Authors:Huang, H.W., Mohan, S.K., Yu, C.
Deposit date:2010-03-08
Release date:2011-02-23
Method:SOLUTION NMR
Cite:The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin
Biochem.Biophys.Res.Commun., 402, 2010
3EGF
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SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS
Descriptor:EPIDERMAL GROWTH FACTOR (EGF) (NMR, 16 STRUCTURES AFTER ENERGY MINIMIZATION)
Authors:Montelione, G.T., Wuthrich, K., Scheraga, H.A.
Deposit date:1992-08-30
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints.
Biochemistry, 31, 1992
3N8W
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CRYSTAL STRUCTURE OF R120Q/NATIVE CYCLOOXYGENASE-1 HETERODIMER MUTANT IN COMPLEX WITH FLURBIPROFEN
Descriptor:Prostaglandin G/H synthase 1 (E.C.1.14.99.1)
Authors:Sidhu, R.S.
Deposit date:2010-05-28
Release date:2010-07-28
Modification date:2010-09-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
3N8Y
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STRUCTURE OF ASPIRIN ACETYLATED CYCLOOXYGENASE-1 IN COMPLEX WITH DICLOFENAC
Descriptor:Prostaglandin G/H synthase 1 (E.C.1.14.99.1)
Authors:Sidhu, R.S.
Deposit date:2010-05-28
Release date:2010-07-28
Modification date:2013-09-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
1APO
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THREE-DIMENSIONAL STRUCTURE OF THE APO FORM OF THE N-TERMINAL EGF-LIKE MODULE OF BLOOD COAGULATION FACTOR X AS DETERMINED BY NMR SPECTROSCOPY AND SIMULATED FOLDING
Descriptor:EGF-LIKE MODULE OF BLOOD COAGULATION FACTOR X (N-TERMINAL, APO FORM) (NMR, 13 STRUCTURES)
Authors:Ullner, M., Selander, M., Persson, E., Stenflo, J., Drakenberg, T., Teleman, O.
Deposit date:1992-04-21
Release date:1994-01-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional structure of the apo form of the N-terminal EGF-like module of blood coagulation factor X as determined by NMR spectroscopy and simulated folding.
Biochemistry, 31, 1992
1BF9
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N-TERMINAL EGF-LIKE DOMAIN FROM HUMAN FACTOR VII, NMR, 23 STRUCTURES
Descriptor:FACTOR VII
Authors:Muranyi, A., Finn, B.E., Gippert, G.P., Forsen, S., Stenflo, J., Drakenberg, T.
Deposit date:1998-05-28
Release date:1999-02-16
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal EGF-like domain from human factor VII.
Biochemistry, 37, 1998
1CCF
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HOW AN EPIDERMAL GROWTH FACTOR (EGF)-LIKE DOMAIN BINDS CALCIUM-HIGH RESOLUTION NMR STRUCTURE OF THE CALCIUM FORM OF THE NH2-TERMINAL EGF-LIKE DOMAIN IN COAGULATION FACTOR X
Descriptor:COAGULATION FACTOR X (THE CALCIUM FORM OF THE N-TERMINAL EGF-LIKE MODULE) (NMR, 15 STRUCTURES)
Authors:Selander-Sunnerhagen, M., Ullner, M., Persson, M., Teleman, O., Stenflo, J., Drakenberg, T.
Deposit date:1993-05-19
Release date:1994-05-31
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.
J.Biol.Chem., 267, 1992
1CQE
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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1 (E.C.1.14.99.1)
Authors:Picot, D., Loll, P.J., Mulichak, A.M., Garavito, R.M.
Deposit date:1999-06-15
Release date:1999-06-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
Nature, 367, 1994
1CVU
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CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Descriptor:PROSTAGLANDIN H2 SYNTHASE-2 (EC 1.14.99.1)
Authors:Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., Stegeman, R.A., Gierse, J.K., Stevens, A.M., Goodwin, D.C., Rowlinson, S.W., Marnett, L.J., Stallings, W.C., Kurumbail, R.G.
Deposit date:1999-08-24
Release date:2000-05-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
1CX2
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CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558
Descriptor:CYCLOOXYGENASE-2, PROTOPORPHYRIN IX CONTAINING FE, 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE
Authors:Kurumbail, R., Stallings, W.
Deposit date:1996-12-17
Release date:1997-12-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Nature, 384, 1996
1DDX
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CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE
Descriptor:PROSTAGLANDIN H2 SYNTHASE-2
Authors:Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., Stegeman, R.A., Gierse, J.K., Stevens, A.M., Goodwin, D.C., Rowlinson, S.W., Marnett, L.J., Stallings, W.C., Kurumbail, R.G.
Deposit date:1999-11-11
Release date:2000-05-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
1DIY
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CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1 (E.C.1.14.99.1)
Authors:Malkowski, M.G., Ginell, S.L., Smith, W.L., Garavito, R.M.
Deposit date:1999-11-30
Release date:2000-09-22
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The productive conformation of arachidonic acid bound to prostaglandin synthase.
Science, 289, 2000
1EBV
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OVINE PGHS-1 COMPLEXED WITH SALICYL HYDROXAMIC ACID
Descriptor:OVINE PGHS-1 COMPLEXED WITH SALICYL HYDROXAMIC ACID (E.C.1.14.99.1)
Authors:Loll, P.J., Sharkey, C.T., O'Connor, S.J., Fitzgerald, D.J.
Deposit date:2000-01-24
Release date:2000-02-24
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions.
Mol.Pharmacol., 60, 2001
1EDM
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EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX
Descriptor:FACTOR IX
Authors:Rao, Z., Handford, P., Mayhew, M., Knott, V., Brownlee, G.G., Stuart, D.
Deposit date:1996-03-21
Release date:1996-10-14
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.
Cell(Cambridge,Mass.), 82, 1995
1EQG
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THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN
Descriptor:PROSTAGLANDIN H SYNTHASE-1 (E.C.1.14.99.1)
Authors:Loll, P.J., Selinsky, B.S., Gupta, K., Sharkey, C.T.
Deposit date:2000-04-04
Release date:2001-04-11
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
Biochemistry, 40, 2001
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