2M3O
| Structure and dynamics of a human Nedd4 WW domain-ENaC complex | Descriptor: | Amiloride-sensitive sodium channel subunit alpha, E3 ubiquitin-protein ligase NEDD4 | Authors: | Bobby, R, Medini, K, Neudecker, P, Lee, V, MacDonald, F.J, Brimble, M.A, Lott, J, Dingley, A.J. | Deposit date: | 2013-01-23 | Release date: | 2013-08-28 | Method: | SOLUTION NMR | Cite: | Structure and dynamics of human Nedd4-1 WW3 in complex with the alpha ENaC PY motif. Biochim.Biophys.Acta, 1834, 2013
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5AHT
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3M7F
| Crystal structure of the Nedd4 C2/Grb10 SH2 complex | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10 | Authors: | Huang, Q, Szebenyi, M. | Deposit date: | 2010-03-16 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4. J.Biol.Chem., 285, 2010
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1I5H
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3B7Y
| Crystal structure of the C2 Domain of the E3 Ubiquitin-Protein Ligase NEDD4 | Descriptor: | CALCIUM ION, E3 ubiquitin-protein ligase NEDD4 | Authors: | Walker, J.R, Ruzanov, M, Butler-Cole, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-10-31 | Release date: | 2007-11-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | C2 Domain of the Human E3 Ubiquitin-Protein Ligase NEDD4. To be Published
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2N8U
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2N8S
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2KPZ
| Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein Derived Peptide SDPQIPPPYVEP | Descriptor: | 12-mer from Gag-Pro polyprotein, E3 ubiquitin-protein ligase NEDD4 | Authors: | Iglesias-Bexiga, M, Macias, M, Bonet, R, Blanco, F.J, Cobos, E.S, Luque, I. | Deposit date: | 2009-10-23 | Release date: | 2010-11-03 | Last modified: | 2020-02-26 | Method: | SOLUTION NMR | Cite: | Human NEDD4 3RD WW Domain Complex with Human T-cell Leukemia virus GAP-Pro Poliprotein Derived Peptide To be Published
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2KQ0
| Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide ILPTAPPEYMEA | Descriptor: | 12-mer from Matrix protein VP40, E3 ubiquitin-protein ligase NEDD4 | Authors: | Iglesias-Bexiga, M, Macias, M, Bonet, R, Blanco, F.J, Cobos, E.S, Luque, I. | Deposit date: | 2009-10-23 | Release date: | 2010-11-03 | Last modified: | 2020-02-26 | Method: | SOLUTION NMR | Cite: | Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide To be Published
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6ZBT
| Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342 | Descriptor: | 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like | Authors: | Joshi, R, Kalabova, D, Obsil, T, Obsilova, V. | Deposit date: | 2020-06-09 | Release date: | 2021-07-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.79948521 Å) | Cite: | 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
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6ZC9
| Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 | Descriptor: | 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like | Authors: | Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. | Deposit date: | 2020-06-10 | Release date: | 2021-07-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.89895988 Å) | Cite: | 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
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2NSQ
| Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase NEDD4-like protein, GLYCEROL | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-06 | Release date: | 2006-12-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein To be Published
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4BBN
| NEDD4 HECT-Ub:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B | Authors: | Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S. | Deposit date: | 2012-09-27 | Release date: | 2013-05-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming Nat.Struct.Mol.Biol., 20, 2013
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2EZ5
| Solution Structure of the dNedd4 WW3* Domain- Comm LPSY Peptide Complex | Descriptor: | Commissureless LPSY Peptide, E3 ubiquitin-protein ligase NEDD4 | Authors: | Kanelis, V, Bruce, M.C, Skrynnikov, N.R, Rotin, D, Forman-Kay, J.D. | Deposit date: | 2005-11-10 | Release date: | 2006-03-28 | Last modified: | 2022-12-21 | Method: | SOLUTION NMR | Cite: | Structural Determinants for High-Affinity Binding in a Nedd4 WW3(*) Domain-Comm PY Motif Complex Structure, 14, 2006
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4BE8
| NEDD4 HECT A889F structure | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4 | Authors: | Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S. | Deposit date: | 2013-03-06 | Release date: | 2013-05-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.996 Å) | Cite: | Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming Nat.Struct.Mol.Biol., 20, 2013
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2XBB
| Nedd4 HECT:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN | Authors: | Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S. | Deposit date: | 2010-04-08 | Release date: | 2011-03-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation Embo Rep., 12, 2011
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2XBF
| Nedd4 HECT structure | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE NEDD4 | Authors: | Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S. | Deposit date: | 2010-04-09 | Release date: | 2011-03-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation Embo Rep., 12, 2011
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5C91
| NEDD4 HECT with covalently bound indole-based inhibitor | Descriptor: | E3 ubiquitin-protein ligase NEDD4, methyl (2E)-4-{[(5-methoxy-1,2-dimethyl-1H-indol-3-yl)carbonyl]amino}but-2-enoate | Authors: | Span, I, Smith, A.T, Kathman, S, Statsyuk, A.V, Rosenzweig, A.C. | Deposit date: | 2015-06-26 | Release date: | 2015-09-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J. Am. Chem. Soc., 137, 2015
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2ONI
| Catalytic Domain of the Human NEDD4-like E3 Ligase | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like protein, SODIUM ION | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-01-24 | Release date: | 2007-04-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | NEDD4-like E3 Ubiquitin-protein Ligase To be Published
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7NMZ
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2N8T
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1WR7
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4N7F
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2D9I
| Solution structure of the SMR domain of NEDD4-binding protein 2 | Descriptor: | NEDD4-binding protein 2 | Authors: | Zhang, H.P, Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-09 | Release date: | 2006-06-09 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of the SMR domain of NEDD4-binding protein 2 to be published
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5C7J
| CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C | Authors: | Walker, J.R, Hu, J, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2015-06-24 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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