Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4BJX
DownloadVisualize
BU of 4bjx by Molmil
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)
Descriptor: 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid, BROMODOMAIN-CONTAINING PROTEIN 4
Authors:Chung, C.
Deposit date:2013-04-20
Release date:2013-10-02
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models.
Plos One, 8, 2013
7ZTL
DownloadVisualize
BU of 7ztl by Molmil
Crystal structure of a covalently linked Aurora-A N-Myc complex
Descriptor: 4-(3-hydroxy-3-oxopropylamino)-4-oxidanylidene-butanoic acid, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Diebold, M, Schindelin, H.
Deposit date:2022-05-11
Release date:2023-01-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a covalently linked Aurora-A-MYCN complex
Acta Crystallogr.,Sect.D, 79, 2023
4J8N
DownloadVisualize
BU of 4j8n by Molmil
Aurora A Kinase Apo
Descriptor: Aurora kinase A
Authors:Meyerowitz, J.G, Gustafson, W.C, Shokat, K.M, Weiss, W.A.
Deposit date:2013-02-14
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.135 Å)
Cite:Drugging MYCN through an Allosteric Transition in Aurora Kinase A.
Cancer Cell, 26, 2014
4J8M
DownloadVisualize
BU of 4j8m by Molmil
Aurora A in complex with CD532
Descriptor: 1,2-ETHANEDIOL, 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea, Aurora kinase A, ...
Authors:Meyerowitz, J.G, Gustafson, W.C, Shokat, K.M, Weiss, W.A.
Deposit date:2013-02-14
Release date:2014-09-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:Drugging MYCN through an Allosteric Transition in Aurora Kinase A.
Cancer Cell, 26, 2014
5G1X
DownloadVisualize
BU of 5g1x by Molmil
Crystal structure of Aurora-A kinase in complex with N-Myc
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ...
Authors:Richards, M.W, Burgess, S.G, Bayliss, R.
Deposit date:2016-03-31
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors
Proc.Natl.Acad.Sci.USA, 113, 2016
5Z3R
DownloadVisualize
BU of 5z3r by Molmil
Crystal Structure of Delta 5-3-Ketosteroid Isomerase from Mycobacterium sp.
Descriptor: Steroid delta-isomerase
Authors:Cheng, X.Y, Peng, F, Yang, F, Huang, Y.Q, Su, Z.D.
Deposit date:2018-01-08
Release date:2018-01-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structure-based reconstruction of a Mycobacterium hypothetical protein into an active Delta5-3-ketosteroid isomerase.
Biochim Biophys Acta Proteins Proteom, 1867, 2019
7WVK
DownloadVisualize
BU of 7wvk by Molmil
Crystal structure of human WDR5 in complex with compound 19
Descriptor: 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ...
Authors:Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F.
Deposit date:2022-02-10
Release date:2022-10-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma.
Acta Pharmacol.Sin., 44, 2023
6WJL
DownloadVisualize
BU of 6wjl by Molmil
Crystal structure of Glypican-2 core protein in complex with D3 Fab
Descriptor: D3 Fab Heavy chain, D3 Fab Light Chain, Glypican-2, ...
Authors:Raman, S, Maris, J.M, Bosse, K.R, Julien, J.P.
Deposit date:2020-04-14
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.
Cell Rep Med, 2, 2021
3LQ5
DownloadVisualize
BU of 3lq5 by Molmil
Structure of CDK9/CyclinT in complex with S-CR8
Descriptor: (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1
Authors:Hole, A.J, Endicott, J.A, Baumli, S.
Deposit date:2010-02-08
Release date:2011-01-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Genes Cancer, 1, 2010
6VAJ
DownloadVisualize
BU of 6vaj by Molmil
Crystal Structure Analysis of human PIN1
Descriptor: 2-chloro-N-(2,2-dimethylpropyl)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, ...
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2019-12-17
Release date:2020-12-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat.Chem.Biol., 17, 2021
6Q3Z
DownloadVisualize
BU of 6q3z by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k
Descriptor: (7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-[(4-methylthiophen-2-yl)methyl]-7~{H}-pteridin-6-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4
Authors:Heidenreich, D, Watts, E, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S, Hoelder, S, Structural Genomics Consortium (SGC)
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity.
J.Med.Chem., 62, 2019
6Q3Y
DownloadVisualize
BU of 6q3y by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16i
Descriptor: (7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-(phenylmethyl)-7~{H}-pteridin-6-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4
Authors:Heidenreich, D, Watts, E, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S, Hoelder, S, Structural Genomics Consortium (SGC)
Deposit date:2018-12-04
Release date:2019-03-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity.
J.Med.Chem., 62, 2019

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon