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1T39
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BU of 1t39 by Molmil
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE COVALENTLY CROSSLINKED TO DNA
Descriptor: 5'-D(*GP*CP*CP*AP*TP*GP*(E1X)P*CP*TP*AP*GP*TP*A)-3', 5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3', Methylated-DNA--protein-cysteine methyltransferase
Authors:Daniels, D.S, Woo, T.T, Luu, K.X, Noll, D.M, Clarke, N.D, Pegg, A.E, Tainer, J.A.
Deposit date:2004-04-25
Release date:2004-07-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:DNA binding and nucleotide flipping by the human DNA repair protein AGT.
Nat.Struct.Mol.Biol., 11, 2004
1T38
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BU of 1t38 by Molmil
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BOUND TO DNA CONTAINING O6-METHYLGUANINE
Descriptor: 5'-D(*GP*CP*CP*AP*TP*GP*(6OG)P*CP*TP*AP*GP*TP*A)-3', 5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3', Methylated-DNA--protein-cysteine methyltransferase
Authors:Daniels, D.S, Woo, T.T, Luu, K.X, Noll, D.M, Clarke, N.D, Pegg, A.E, Tainer, J.A.
Deposit date:2004-04-25
Release date:2004-07-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:DNA binding and nucleotide flipping by the human DNA repair protein AGT.
Nat.Struct.Mol.Biol., 11, 2004
1YFH
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wt Human O6-Alkylguanine-DNA Alkyltransferase Bound To DNA Containing an Alkylated Cytosine
Descriptor: 5'-D(*CP*CP*TP*AP*CP*AP*CP*AP*CP*AP*TP*CP*CP*AP*CP*A)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*(XCY)P*GP*TP*GP*TP*AP*GP*GP*T)-3', Methylated-DNA--protein-cysteine methyltransferase, ...
Authors:Duguid, E.M, Rice, P.A, He, C.
Deposit date:2004-12-31
Release date:2005-12-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:The structure of the human AGT protein bound to DNA and its implications for damage detection.
J.Mol.Biol., 350, 2005
1EH8
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BU of 1eh8 by Molmil
BENZYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Descriptor: O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, ZINC ION
Authors:Daniels, D.S, Tainer, J.A.
Deposit date:2000-02-18
Release date:2000-04-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
EMBO J., 19, 2000
1EH7
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METHYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Descriptor: O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, ZINC ION
Authors:Daniels, D.S, Tainer, J.A.
Deposit date:2000-02-18
Release date:2000-04-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
EMBO J., 19, 2000
1EH6
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BU of 1eh6 by Molmil
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE
Descriptor: O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE, ZINC ION
Authors:Daniels, D.S, Tainer, J.A.
Deposit date:2000-02-18
Release date:2000-04-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
EMBO J., 19, 2000
1QNT
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BU of 1qnt by Molmil
X-ray structure of human O6alkylguanine-DNA alkyltransferase
Descriptor: METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Authors:Wibley, J.E.A, Moody, P.C.E.
Deposit date:1999-10-20
Release date:1999-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human O(6)-Alkylguanine-DNA Alkyltransferase.
Nucleic Acids Res., 28, 2000
1MGT
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BU of 1mgt by Molmil
CRYSTAL STRUCTURE OF O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM HYPERTHERMOPHILIC ARCHAEON PYROCOCCUS KODAKARAENSIS STRAIN KOD1
Descriptor: PROTEIN (O6-METHYLGUANINE-DNA METHYLTRANSFERASE), SULFATE ION
Authors:Hashimoto, H, Inoue, T, Nishioka, M, Fujiwara, S, Takagi, M, Imanaka, T, Kai, Y.
Deposit date:1999-01-12
Release date:2000-01-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase.
J.Mol.Biol., 292, 1999
8RGG
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BU of 8rgg by Molmil
Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1.
Descriptor: Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Dynein light chain 1, ...
Authors:Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Mladenov, M, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J.
Deposit date:2023-12-13
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport.
Embo J., 2024
8RGH
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BU of 8rgh by Molmil
Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1.
Descriptor: Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Cytoplasmic dynein 2 light intermediate chain 1, ...
Authors:Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J.
Deposit date:2023-12-13
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport.
Embo J., 2024
2G7H
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BU of 2g7h by Molmil
Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)
Descriptor: Methylated-DNA--protein-cysteine methyltransferase
Authors:Roberts, A.
Deposit date:2006-02-28
Release date:2006-08-01
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural studies of MJ1529, an O(6)-methylguanine-DNA methyltransferase
Magn.Reson.Chem., 44, 2006
6GA0
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BU of 6ga0 by Molmil
Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with SNAP-Vista Green
Descriptor: 5-[(4-methylphenyl)methylcarbamoyl]-2-(6-oxidanyl-3-oxidanylidene-4~{H}-xanthen-9-yl)benzoic acid, Methylated-DNA--protein-cysteine methyltransferase, SULFATE ION
Authors:Miggiano, R, Rossi, F, Rizzi, M.
Deposit date:2018-04-11
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe.
Biochem. Biophys. Res. Commun., 500, 2018
8AES
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BU of 8aes by Molmil
Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag
Descriptor: Methylated-DNA--protein-cysteine methyltransferase
Authors:Genta, M, Perugino, G, Miggiano, R.
Deposit date:2022-07-13
Release date:2022-10-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:First thermostable CLIP- tag by rational design applied to an archaeal O 6 -alkyl-guanine-DNA-alkyl-transferase.
Comput Struct Biotechnol J, 20, 2022
4BHC
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BU of 4bhc by Molmil
CRYSTAL STRUCTURE OF THE M. TUBERCULOSIS O6-METHYLGUANINE METHYLTRANSFERASE R37L VARIANT
Descriptor: METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Authors:Miggiano, R, Casazza, V, Garavaglia, S, Ciaramella, M, Perugino, G, Rizzi, M, Rossi, F.
Deposit date:2013-04-02
Release date:2013-04-17
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Biochemical and Structural Studies on the M. Tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants.
J.Bacteriol., 195, 2013
4BHB
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BU of 4bhb by Molmil
Crystal structure of Mycobacterium tuberculosis O6-METHYLGUANINE METHYLTRANSFERASE
Descriptor: GLYCEROL, METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE
Authors:Miggiano, R, Casazza, V, Garavaglia, S, Ciaramella, M, Perugino, G, Rizzii, M, Rossi, F.
Deposit date:2013-04-02
Release date:2013-04-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical and Structural Studies of the Mycobacterium Tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants.
J.Bacteriol., 195, 2013
8BBG
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BU of 8bbg by Molmil
Structure of the IFT-A complex; anterograde IFT-A train model
Descriptor: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ...
Authors:Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J.
Deposit date:2022-10-12
Release date:2022-12-21
Last modified:2023-01-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:IFT-A structure reveals carriages for membrane protein transport into cilia.
Cell, 185, 2022
8BBE
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BU of 8bbe by Molmil
Structure of the IFT-A complex; IFT-A2 module
Descriptor: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, SNAP-tag,Tetratricopeptide repeat protein 21B, ...
Authors:Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J.
Deposit date:2022-10-12
Release date:2022-12-21
Last modified:2023-01-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:IFT-A structure reveals carriages for membrane protein transport into cilia.
Cell, 185, 2022
5OTN
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BU of 5otn by Molmil
Crystal structure of zebrafish MTH1 in complex with O6-methyl-dGMP
Descriptor: 1,2-ETHANEDIOL, 6-O-METHYL GUANOSINE-5'-MONOPHOSPHATE, CALCIUM ION, ...
Authors:Gustafsson, R, Henriksson, L, Jemth, A.-S, Brautigam, L, Carreras Puigvert, J, Homan, E, Warpman Berglund, U, Helleday, T, Stenmark, P.
Deposit date:2017-08-22
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Nucleic Acids Res., 46, 2018
5OTM
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BU of 5otm by Molmil
Crystal structure of human MTH1 in complex with O6-methyl-dGMP
Descriptor: 6-O-METHYL GUANOSINE-5'-MONOPHOSPHATE, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
Authors:Gustafsson, R, Henriksson, L, Jemth, A.-S, Brautigam, L, Carreras Puigvert, J, Homan, E, Warpman Berglund, U, Helleday, T, Stenmark, P.
Deposit date:2017-08-22
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Nucleic Acids Res., 46, 2018
1WRJ
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BU of 1wrj by Molmil
Crystal structure of O6-methylguanine methyltransferase from Sulfolobus tokodaii
Descriptor: Methylated-DNA--protein-cysteine methyltransferase
Authors:Kuroda, M, Tsunoda, M, Nakamura, K.T.
Deposit date:2004-10-18
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of O6-methylguanine methyltransferase from Sulfolobus tokodaii
To be Published
6WY5
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BU of 6wy5 by Molmil
CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-37 A.K.A 7-(1-phenyl-3-(((1S,3S)-3-phenyl-2,3-dihydro-1H-inden-1-yl)amino)propyl)-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[(1R)-1-phenyl-3-{[(1S,3S)-3-phenyl-2,3-dihydro-1H-inden-1-yl]amino}propyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, ...
Authors:Khan, J.A.
Deposit date:2020-05-12
Release date:2020-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.898 Å)
Cite:Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg.Med.Chem., 28, 2020
6WY7
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CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-41 A.K.A 7-[1-phenyl-3-({4-phenylbicyclo[2.2.2]octan-1-yl}amino)propyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-{(1R)-1-phenyl-3-[(4-phenylbicyclo[2.2.2]octan-1-yl)amino]propyl}-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, CALCIUM ION, ...
Authors:Khan, J.A.
Deposit date:2020-05-12
Release date:2020-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.089 Å)
Cite:Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg.Med.Chem., 28, 2020
6WY0
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CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-40 A.K.A 7-[(1R)-1-phenyl-3-{[(1r,4r)-4-phenylcyclohexyl]amino}propyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-{(1R)-1-phenyl-3-[(trans-4-phenylcyclohexyl)amino]propyl}-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, ...
Authors:Khan, J.A.
Deposit date:2020-05-12
Release date:2020-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg.Med.Chem., 28, 2020
6WXZ
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BU of 6wxz by Molmil
CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-29 A.K.A 7-(1,2-DIPHENYLETHYL)-1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[(1R)-1,2-diphenylethyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, CALCIUM ION, ...
Authors:Khan, J.A.
Deposit date:2020-05-12
Release date:2020-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.226 Å)
Cite:Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg.Med.Chem., 28, 2020
6WYD
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BU of 6wyd by Molmil
CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-12 (AKA; 7-benzyl-1H-[1,2,3]triazolo[4,5-b]pyrid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-benzyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, CALCIUM ION, ...
Authors:Khan, J.A.
Deposit date:2020-05-12
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg.Med.Chem., 28, 2020

 

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