PDB: 12 resultsInfo pagesStatus searchChemie searchBIRD

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1C7U	Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide Descriptor: 5'-D(*CP*TP*CP*GP*GP*CP*TP*AP*TP*TP*AP*AP*TP*AP*GP*CP*CP*GP*AP*G)-3', MYOCYTE-SPECIFIC ENHANCER FACTOR 2A, C4 FORM Authors: Clore, G.M, Huang, K. Deposit date: 2000-03-17 Release date: 2000-03-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors Embo J., 19, 2000
1EGW	CRYSTAL STRUCTURE OF MEF2A CORE BOUND TO DNA Descriptor: DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), MADS BOX TRANSCRIPTION ENHANCER FACTOR 2, ... Authors: Santelli, E, Richmond, T.J. Deposit date: 2000-02-17 Release date: 2000-03-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of MEF2A core bound to DNA at 1.5 A resolution. J.Mol.Biol., 297, 2000
3KOV	Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors Descriptor: DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte-specific enhancer factor 2A Authors: Wu, Y, Dey, R, Han, A, Jayathilaka, N, Philips, M, Ye, J, Chen, L. Deposit date: 2009-11-14 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment. J.Mol.Biol., 397, 2010
1LEW	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A Descriptor: Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A Authors: Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. Deposit date: 2002-04-10 Release date: 2002-07-10 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
1LEZ	CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B Descriptor: MAP kinase kinase 3b, MITOGEN-ACTIVATED PROTEIN KINASE 14 Authors: Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J. Deposit date: 2002-04-10 Release date: 2002-07-10 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol.Cell, 9, 2002
6BYY	MEF2 CHIMERA/DNA Complex Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ... Authors: Lei, X, Chen, L. Deposit date: 2017-12-21 Release date: 2018-01-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B. J. Mol. Biol., 430, 2018
6WC2	Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex Descriptor: Homeobox protein Nkx-2.5, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA Authors: Lei, X, Chen, L. Deposit date: 2020-03-29 Release date: 2020-07-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432, 2020
3MU6	Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules Descriptor: (3E)-N~8~-(2-aminophenyl)-N~1~-phenyloct-3-enediamide, DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3'), ... Authors: Jayathilaka, N, Han, A, Gaffney, K, Dey, R, He, J, Ye, J, Gao, T, Petasis, N.A, Chen, L. Deposit date: 2010-05-01 Release date: 2011-11-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.434 Å) Cite: Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res., 40, 2012
6BZ1	MEF2 Chimera D83V mutant/DNA complex Descriptor: DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), MEF2 CHIMERA Authors: Lei, X, Chen, L. Deposit date: 2017-12-21 Release date: 2018-02-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.97 Å) Cite: The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B. J. Mol. Biol., 430, 2018
7XUZ	Crystal structure of a HDAC4-MEF2A-DNA ternary complex Descriptor: DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... Authors: Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. Deposit date: 2022-05-20 Release date: 2023-11-29 Method: X-RAY DIFFRACTION (3.591 Å) Cite: Structural insights into transcription regulation by the higher-order HDAC4-MEF2-DNA complex To Be Published
3P57	Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA Descriptor: DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ... Authors: He, J, Ye, J, Riquelme, C, Liu, J.O. Deposit date: 2010-10-08 Release date: 2011-08-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1921 Å) Cite: Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Res., 39, 2011
1TQE	Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 Descriptor: Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B Authors: Chen, L, Han, A, He, J, Wu, Y, Liu, J.O. Deposit date: 2004-06-17 Release date: 2004-12-21 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2. J.Mol.Biol., 345, 2005