PDB: 14 resultsInfo pagesStatus searchChemie searchBIRD

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6TD4	IRF4 DNA-binding domain surface entropy mutant apo structure Descriptor: CHLORIDE ION, Interferon regulatory factor 4 Authors: Tucker, J.A, Martin, M.P, Wang, L.Z, Jennings, C, Heath, R. Deposit date: 2019-11-07 Release date: 2020-11-18 Last modified: 2021-06-23 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Cancer-associated mutations in the IRF4 DNA-binding domain confer no disadvantage in DNA-binding affinity and may increase transcriptional activity To Be Published
7RH2	IRF4 Transcription factor mutant -K59R Descriptor: DNA (5'-D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), ICSAT transcription factor Authors: Williams, S.J, Sundararaj, S, Casarotto, M.G. Deposit date: 2021-07-16 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.47 Å) Cite: The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4 K59R mutation. Protein Sci., 31, 2022
7JM4	IRF Transcription Factor Descriptor: Interferon regulatory factor 4, Interferon-Stimulated Response Elements Authors: Sundararaj, S, Williams, S.J, Casarotto, M.G. Deposit date: 2020-07-31 Release date: 2021-03-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural determinants of the IRF4/DNA homodimeric complex. Nucleic Acids Res., 49, 2021
8JKL	IRF4 DNA-binding domain bound to an DNA containing GATA motif Descriptor: GATA-Forward, GATA-Reverse, Interferon regulatory factor 4 Authors: Wang, G, Feng, X, Ding, J. Deposit date: 2023-06-01 Release date: 2023-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
8JKN	T95R mutant IRF4 DNA-binding domain bound to an DNA containing GAAA motif Descriptor: GAAA-Forward, GAAA-Reverse, Interferon regulatory factor 4 Authors: Wang, G, Feng, X, Ding, J. Deposit date: 2023-06-01 Release date: 2023-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
8JKQ	T95R mutant IRF4 DNA-binding domain bound to an DNA containing GACA motif Descriptor: GACA-Forward, GACA-Reverse, Interferon regulatory factor 4 Authors: Wang, G, Feng, X, Ding, J. Deposit date: 2023-06-01 Release date: 2023-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
8JKO	T95R mutant IRF4 DNA-binding domain bound to an DNA containing GATA motif Descriptor: GATA-Forward, GATA-Reverse, Interferon regulatory factor 4 Authors: Wang, G, Feng, X, Ding, J. Deposit date: 2023-06-01 Release date: 2023-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
8JKS	T95R mutant IRF4 DNA-binding domain bound to an DNA containing GAGA motif Descriptor: GAGA-Forward, GAGA-Reverse, Interferon regulatory factor 4 Authors: Wang, G, Feng, X, Ding, J. Deposit date: 2023-06-01 Release date: 2023-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
5BVI	X-ray Structure of Interferon Regulatory Factor 4 IAD Domain Descriptor: CHLORIDE ION, Interferon regulatory factor 4 Authors: Escalate, C.R, Remesh, S.G. Deposit date: 2015-06-05 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain. J.Biol.Chem., 290, 2015
7O56	X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element solved by Phosphorus and Sulphur SAD methods Descriptor: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*AP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*TP*TP*TP*TP*AP*T)-3'), Interferon regulatory factor 4 Authors: El Omari, K, Agnarelli, A, Duman, R, Wagner, A, Mancini, E.J. Deposit date: 2021-04-07 Release date: 2021-05-12 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4. Acta Crystallogr.,Sect.F, 77, 2021
2DLL	Solution structure of the IRF domain of human interferon regulator factors 4 Descriptor: Interferon regulatory factor 4 Authors: Zhang, H.P, Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-20 Release date: 2006-10-20 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of the IRF domain of human interferon regulator factors 4 To be published
7OGS	X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element Descriptor: DNA (5'-D(P*AP*TP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*TP*GP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*A)-3'), Interferon regulatory factor 4 Authors: Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J. Deposit date: 2021-05-07 Release date: 2022-06-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.37 Å) Cite: X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element To Be Published
7OOT	X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element Descriptor: DNA (5'-D(P*AP*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), DNA (5'-D(P*TP*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor 4, ... Authors: Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J. Deposit date: 2021-05-28 Release date: 2022-06-08 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.25 Å) Cite: X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element To Be Published
5U5S	Solution structures of Brd2 second bromodomain in complex with stat3 peptide Descriptor: Bromodomain-containing protein 2, Stat3 peptide Authors: Zeng, L, Zhou, M.-M. Deposit date: 2016-12-07 Release date: 2017-03-22 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol. Cell, 65, 2017