8HE0
 
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2ILM
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5JWP
 | | Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide. | | Descriptor: | 2-OXOGLUTARIC ACID, GLYCEROL, Hypoxia-inducible factor 1-alpha, ... | | Authors: | Taabazuing, C.Y, Garman, S.C, Eron, S, Knapp, M.J. | | Deposit date: | 2016-05-12 | | Release date: | 2016-11-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.
J.Inorg.Biochem., 166, 2016
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7LVS
 | | The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide | | Descriptor: | Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone lysine acetyltransferase CREBBP, ZINC ION | | Authors: | Appling, F.D, Berlow, R.B, Stanfield, R.L, Dyson, H.J, Wright, P.E. | | Deposit date: | 2021-02-26 | | Release date: | 2021-07-28 | | Last modified: | 2021-12-15 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | The molecular basis of allostery in a facilitated dissociation process.
Structure, 29, 2021
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4ZPR
 | | Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA | | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... | | Authors: | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | | Deposit date: | 2015-05-08 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.902 Å) | | Cite: | Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
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3HQU
 | | PHD2:Fe:UN9:partial HIF1-alpha substrate complex | | Descriptor: | Egl nine homolog 1, FE (II) ION, Hypoxia-inducible factor 1 alpha, ... | | Authors: | Chowdhury, R, McDonough, M.A, Schofield, C.J. | | Deposit date: | 2009-06-08 | | Release date: | 2009-07-28 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
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4H6J
 | | Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction. | | Descriptor: | ARYL HYDROCARBON NUCLEAR TRANSLOCATOR, HYPOXIA INDUCIBLE FACTOR 1-ALPHA | | Authors: | Cardoso, R, Love, R.A, Nilsson, C, Bergqvist, S, Nowlin, D, Yan, J, Liu, K, Zhu, J, Chen, P, Deng, Y.-L, Dyson, H.J, Greig, M.J, Brooun, A. | | Deposit date: | 2012-09-19 | | Release date: | 2012-12-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
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6YW3
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7QGS
 | | Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) | | Descriptor: | Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION | | Authors: | Hegedus, Z, Wilson, A.J, Edwards, T.A. | | Deposit date: | 2021-12-10 | | Release date: | 2022-05-11 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Understanding p300-transcription factor interactions using sequence variation and hybridization.
Rsc Chem Biol, 3, 2022
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4AJY
 | | von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide | | Descriptor: | GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... | | Authors: | Van Molle, I, Thomann, A, Buckley, D.L, So, E.C, Lang, S, Crews, C.M, Ciulli, A. | | Deposit date: | 2012-02-21 | | Release date: | 2012-11-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
Chem.Biol., 19, 2012
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5L9B
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5LA9
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3HQR
 | | PHD2:Mn:NOG:HIF1-alpha substrate complex | | Descriptor: | Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... | | Authors: | Chowdhury, R, McDonough, M.A, Schofield, C.J. | | Deposit date: | 2009-06-08 | | Release date: | 2009-07-28 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
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5L9V
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5LAS
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1LM8
 | | Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex | | Descriptor: | ELONGIN B, ELONGIN C, Hypoxia-inducible factor 1 alpha, ... | | Authors: | Min, J.-H, Yang, H, Ivan, M, Gertler, F, Kaelin JR, W.G, Pavletich, N.P. | | Deposit date: | 2002-04-30 | | Release date: | 2002-06-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Science, 296, 2002
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1L8C
 | | STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE | | Descriptor: | CREB-binding protein, Hypoxia-inducible factor 1 alpha, ZINC ION | | Authors: | Dames, S.A, Martinez-Yamout, M, De Guzman, R.N, Dyson, H.J, Wright, P.E. | | Deposit date: | 2002-03-19 | | Release date: | 2002-04-10 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1L3E
 | | NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex | | Descriptor: | ZINC ION, hypoxia inducible factor-1 alpha subunit, p300 protein | | Authors: | Freedman, S.J, Sun, Z.J, Poy, F, Kung, A.L, Livingston, D.M, Wagner, G, Eck, M.J. | | Deposit date: | 2002-02-26 | | Release date: | 2002-04-24 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1LQB
 | | Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex | | Descriptor: | Elongin B, Elongin C, Hypoxia-inducible factor 1 ALPHA, ... | | Authors: | Hon, W.C, Wilson, M.I, Harlos, K, Claridge, T.D, Schofield, C.J, Pugh, C.W, Maxwell, P.H, Ratcliffe, P.J, Stuart, D.I, Jones, E.Y. | | Deposit date: | 2002-05-09 | | Release date: | 2002-07-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature, 417, 2002
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1H2M
 | | Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide | | Descriptor: | FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, N-OXALYLGLYCINE, ... | | Authors: | Elkins, J.M, Hewitson, K.S, McNeill, L.A, Schlemminger, I, Seibel, J.F, Schofield, C.J. | | Deposit date: | 2002-08-12 | | Release date: | 2002-11-28 | | Last modified: | 2018-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
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8HE3
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