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8SRP
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FoxP3 forms Ladder-like multimer to bridge TTTG repeats
Descriptor: DNA 72-mer, Forkhead box protein P3
Authors:Leng, F, Hur, S.
Deposit date:2023-05-05
Release date:2023-10-18
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Nature, 624, 2023
8SRO
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BU of 8sro by Molmil
FoxP3 tetramer on TTTG repeats
Descriptor: DNA 72-mer, Forkhead box protein P3
Authors:Leng, F, Hur, S.
Deposit date:2023-05-05
Release date:2023-10-18
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Nature, 624, 2023
4WK8
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BU of 4wk8 by Molmil
FOXP3 forms a domain-swapped dimer to bridge DNA
Descriptor: DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3
Authors:Chen, Y, Chen, L.
Deposit date:2014-10-01
Release date:2015-01-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.4006 Å)
Cite:DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43, 2015
4I1L
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Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function
Descriptor: ACETATE ION, Forkhead box protein P3, MAGNESIUM ION, ...
Authors:Song, X.M, Greene, M.I, Zhou, Z.C.
Deposit date:2012-11-21
Release date:2012-12-05
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.
Cell Rep, 1, 2012
3QRF
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BU of 3qrf by Molmil
Structure of a domain-swapped FOXP3 dimer
Descriptor: Forkhead box protein P3, MAGNESIUM ION, Nuclear factor of activated T-cells, ...
Authors:Bandukwala, H.S, Wu, Y, Feurer, M, Chen, Y, Barbosa, B, Ghosh, S, Stroud, J.C, Benoist, C, Mathis, D, Rao, A, Chen, L.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
7TDW
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BU of 7tdw by Molmil
Structure of FOXP3-DNA complex
Descriptor: DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*TP*AP*AP*AP*CP*AP*AP*AP*TP*TP*T)-3'), Forkhead box P3
Authors:Leng, F, Hur, S.
Deposit date:2022-01-03
Release date:2022-08-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4 Å)
Cite:The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
Immunity, 55, 2022
7TDX
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BU of 7tdx by Molmil
Structure of FOXP3-DNA complex
Descriptor: DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*TP*AP*AP*AP*CP*AP*AP*AP*TP*TP*T)-3'), Forkhead box P3
Authors:Leng, F, Hur, S.
Deposit date:2022-01-03
Release date:2022-08-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
Immunity, 55, 2022
2AS5
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BU of 2as5 by Molmil
Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
Descriptor: 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3', 5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3', Forkhead box protein P2, ...
Authors:Wu, Y, Stroud, J.C, Borde, M, Bates, D.L, Guo, L, Han, A, Rao, A, Chen, L.
Deposit date:2005-08-22
Release date:2006-08-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT.
Cell(Cambridge,Mass.), 126, 2006
6MKD
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4699 TCR bound to I-Ab Padi4
Descriptor: 4699 TCR alpha chain, 4699 TCR beta chain, H-2 class II histocompatibility antigen, ...
Authors:Stadinski, B.D, Blevins, S.J, Huseby, E.S.
Deposit date:2018-09-25
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
6MNO
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BU of 6mno by Molmil
6235 TCR bound to I-Ab Padi4
Descriptor: 6235 TCR alpha chain, 6235 TCR beta chain, H-2 class II histocompatibility antigen, ...
Authors:Stadinski, B.D, Blevins, S.J, Huseby, E.S.
Deposit date:2018-10-02
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
6MKR
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BU of 6mkr by Molmil
5287 TCR bound to IAb Padi4
Descriptor: 5287 TCR alpha chain, 5287 TCR beta chain, H-2 class II histocompatibility antigen, ...
Authors:Stadinski, B.D, Blevins, S.J, Huseby, E.S.
Deposit date:2018-09-26
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.355 Å)
Cite:A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
6MNN
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6236 TCR bound to I-Ab Padi4
Descriptor: 6236 TCR alpha chain, 6236 TCR beta chain, H-2 class II histocompatibility antigen, ...
Authors:Blevins, S.J, Stadinski, B.D, Huseby, E.S.
Deposit date:2018-10-02
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
6MNM
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BU of 6mnm by Molmil
6256 TCR bound to I-Ab Padi4
Descriptor: 6256 TCR alpha chain, 6256 TCR beta chain, H-2 class II histocompatibility antigen, ...
Authors:Blevins, S.J, Stadinski, B.D, Huseby, E.S.
Deposit date:2018-10-02
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
6MNG
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BU of 6mng by Molmil
4738 TCR bound to IAb Padi4
Descriptor: 4738 TCR alpha chain, 4738 TCR beta chain, H-2 class II histocompatibility antigen, ...
Authors:Blevins, S.J, Stadinski, B.D, Huseby, E.S.
Deposit date:2018-10-01
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.662 Å)
Cite:A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
7LM2
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BU of 7lm2 by Molmil
HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 3C
Descriptor: 1,2-ETHANEDIOL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ...
Authors:Lesburg, C.A, Augustin, M.
Deposit date:2021-02-05
Release date:2021-04-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3K delta Immunomodulators.
J.Med.Chem., 64, 2021
2A07
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BU of 2a07 by Molmil
Crystal Structure of Foxp2 bound Specifically to DNA.
Descriptor: 5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3', 5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3', Forkhead box protein P2, ...
Authors:Stroud, J.C, Wu, Y, Bates, D.L, Han, A, Nowick, K, Paabo, S, Tong, H, Chen, L.
Deposit date:2005-06-16
Release date:2006-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Forkhead Domain of FOXP2 Bound to DNA.
Structure, 14, 2006
8C7H
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BU of 8c7h by Molmil
Cryo-EM Map of the latTGF-beta 28G11 Fab complex
Descriptor: 28G11 Fab heavy chain, 28G11 Fab light chain, Transforming growth factor beta activator LRRC32, ...
Authors:Ebenhoch, R, Nar, H.
Deposit date:2023-01-16
Release date:2023-03-01
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Anti-GARP Antibodies Inhibit Release of TGF-beta by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.
Immunohorizons, 7, 2023
6FMF
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BU of 6fmf by Molmil
Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure
Descriptor: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid
Authors:Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P.
Deposit date:2018-01-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.811 Å)
Cite:Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
6FMC
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BU of 6fmc by Molmil
Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure
Descriptor: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1
Authors:Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P.
Deposit date:2018-01-30
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
7SXB
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BU of 7sxb by Molmil
NMR Solution Structure for Domain 3 of Heligmosomoides polygyrus protein Transforming Growth Factor Beta Mimic 1 (TGM-1 D3)
Descriptor: Transforming growth factor mimic
Authors:Mukundan, A, Byeon, C, Hinck, A.P.
Deposit date:2021-11-22
Release date:2022-05-18
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-beta to its receptors, T beta RI and T beta RII.
J.Biol.Chem., 298, 2022
5V4N
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BU of 5v4n by Molmil
Structure of HLA-DR1 with bound alpha3(135-145) peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, alpha3(135-145)-HLA-DRB1*01:01
Authors:Petersen, J, Rossjohn, J.
Deposit date:2017-03-10
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
5V4M
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Structure of HLA-DR15 with bound alpha3(135-145) peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA-DRA1, ...
Authors:Petersen, J, Rossjohn, J.
Deposit date:2017-03-10
Release date:2017-05-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Nature, 545, 2017
5W0Q
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CREBBP Bromodomain in complex with Cpd17 (N,2,7-trimethyl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide)
Descriptor: (2R)-N,2,7-trimethyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, CREB-binding protein, SULFATE ION
Authors:Murray, J.M.
Deposit date:2017-05-31
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0F
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CREBBP Bromodomain in complex with Cpd3 ((S)-1-(3-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Descriptor: 1-{3-[6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein
Authors:Murray, J.M.
Deposit date:2017-05-30
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0L
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CREBBP Bromodomain in complex with Cpd10 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Descriptor: 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein
Authors:Murray, J.M.
Deposit date:2017-05-31
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017

 

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