4X8W
 
 | | dsRBD3 of Loquacious | | Descriptor: | GLYCEROL, Loquacious, isoform B | | Authors: | Jakob, L, Treiber, N, Treiber, T, Stotz, M, Meister, G. | | Deposit date: | 2014-12-10 | | Release date: | 2016-01-13 | | Method: | X-RAY DIFFRACTION (2.647 Å) | | Cite: | Structure of the dsRBD3 of Loquacious reveals features for dimerization and Dicer1-interaction
To Be Published
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7XW3
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7XW2
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2LTS
 | | Solution structure of RDE-4(150-235) | | Descriptor: | Protein RDE-4 | | Authors: | Deshmukh, M, Chiliveri, S. | | Deposit date: | 2012-05-31 | | Release date: | 2013-12-04 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway.
Biochem.J., 458, 2014
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2LTR
 | | Solution structure of RDE-4(32-136) | | Descriptor: | Protein RDE-4 | | Authors: | Deshmukh, M, Chiliveri, S. | | Deposit date: | 2012-05-31 | | Release date: | 2013-12-04 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway.
Biochem.J., 458, 2014
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4WYQ
 | | Crystal structure of the Dicer-TRBP interface | | Descriptor: | Endoribonuclease Dicer, Poly(UNK), RISC-loading complex subunit TARBP2 | | Authors: | Wilson, R.C, Doudna, J.A. | | Deposit date: | 2014-11-18 | | Release date: | 2014-12-17 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis.
Mol.Cell, 57, 2015
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5ZAM
 | | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | | Descriptor: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) | | Authors: | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | | Deposit date: | 2018-02-07 | | Release date: | 2018-05-09 | | Last modified: | 2020-08-05 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.
Cell, 173, 2018
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3C4B
 | | Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer | | Descriptor: | Endoribonuclease Dicer | | Authors: | Lee, J.K, Du, Z, Tjhen, R.J, Stroud, R.M, James, T.L. | | Deposit date: | 2008-01-29 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C4T
 | | Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer | | Descriptor: | CADMIUM ION, Endoribonuclease Dicer | | Authors: | Lee, J.K, Du, Z, Tjhen, R.J, Stroud, R.M, James, T.L. | | Deposit date: | 2008-01-30 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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5ZAL
 | | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | | Descriptor: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) | | Authors: | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | | Deposit date: | 2018-02-07 | | Release date: | 2018-05-09 | | Last modified: | 2020-08-05 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.
Cell, 173, 2018
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7ZPK
 | | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit | | Descriptor: | 59-nt precursor of miR-15a, Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-04-27 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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7YYM
 | | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate | | Descriptor: | 59-nt precursor of miR-15a, Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-02-18 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (4.19 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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7YZ4
 | | Mouse endoribonuclease Dicer (composite structure) | | Descriptor: | Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-02-18 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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7ZPI
 | | Mammalian Dicer in the "dicing state" with pre-miR-15a substrate | | Descriptor: | 59-nt precursor of miR-15a, Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-04-27 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (5.91 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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7YYN
 | | Mammalian Dicer in the dicing state with pre-miR-15a substrate | | Descriptor: | 59-nt precursor of miR-15a, Isoform 2 of Endoribonuclease Dicer | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-02-18 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (6.21 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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7ZPJ
 | | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit | | Descriptor: | 59-nt precursor of miR-15a, Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 isoform 1 | | Authors: | Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. | | Deposit date: | 2022-04-27 | | Release date: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Structural and functional basis of mammalian microRNA biogenesis by Dicer.
Mol.Cell, 82, 2022
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4NGD
 | | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having 5'-p and UU-3' ends (1.95 Angstrom resolution) | | Descriptor: | 5'-R(P*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', DI(HYDROXYETHYL)ETHER, Endoribonuclease Dicer, ... | | Authors: | Tian, Y, Simanshu, D.K, Patel, D.J. | | Deposit date: | 2013-11-01 | | Release date: | 2014-03-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.958 Å) | | Cite: | A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Mol.Cell, 53, 2014
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4NHA
 | | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 16-mer siRNA having 5'-p and UU-3' ends (3.4 Angstrom resolution) | | Descriptor: | 5'-R(P*GP*CP*GP*UP*UP*GP*GP*CP*CP*AP*AP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer | | Authors: | Simanshu, D.K, Tian, Y, Ma, J.-B, Patel, D.J. | | Deposit date: | 2013-11-04 | | Release date: | 2014-03-05 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (3.401 Å) | | Cite: | A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Mol.Cell, 53, 2014
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4NH5
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4NGC
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4NGG
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4NH6
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4NGF
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4NGB
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4NH3
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