4TRF
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4TRU
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5BS9
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5BSC
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5BSI
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4XX8
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4XX7
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2OS5
| Macrophage migration inhibitory factor from Ancylostoma ceylanicum | Descriptor: | AceMIF, SULFATE ION | Authors: | Cho, Y, Lolis, E. | Deposit date: | 2007-02-05 | Release date: | 2007-06-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J.Biol.Chem., 282, 2007
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5UZY
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4P0H
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4P01
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4PKZ
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4PLU
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4GUM
| Cystal structure of locked-trimer of human MIF | Descriptor: | CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C, Lolis, E. | Deposit date: | 2012-08-29 | Release date: | 2013-07-03 | Last modified: | 2020-11-18 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc.Natl.Acad.Sci.USA, 110, 2013
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5EIZ
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6BG7
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6BG6
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3ZBF
| Structure of Human ROS1 Kinase Domain in Complex with Crizotinib | Descriptor: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS | Authors: | McTigue, M, Deng, Y, Liu, W, Brooun, A, Stewart, A. | Deposit date: | 2012-11-08 | Release date: | 2013-06-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1 N.Engl.J.Med., 368, 2013
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7MRV
| F100A mutant structure of MIF2 (D-DT) | Descriptor: | D-dopachrome decarboxylase, SULFATE ION | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | Deposit date: | 2021-05-09 | Release date: | 2021-08-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase. J.Biol.Chem., 297, 2021
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7MRU
| Crystal structure of S62A MIF2 mutant | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | Deposit date: | 2021-05-09 | Release date: | 2021-08-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase. J.Biol.Chem., 297, 2021
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7MW7
| Crystal structure of P1G mutant of D-dopachrome tautomerase | Descriptor: | D-dopachrome decarboxylase, SODIUM ION, SULFATE ION | Authors: | Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E. | Deposit date: | 2021-05-15 | Release date: | 2021-08-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase. J.Biol.Chem., 297, 2021
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7MSE
| High-resolution crystal structure of hMIF2 with tartrate at the active site | Descriptor: | D-dopachrome decarboxylase, L(+)-TARTARIC ACID | Authors: | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | Deposit date: | 2021-05-11 | Release date: | 2021-08-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase. J.Biol.Chem., 297, 2021
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3B64
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8DBB
| Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid | Descriptor: | CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid | Authors: | Parkins, A, Banumathi, S, Pantouris, G. | Deposit date: | 2022-06-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | 2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase. Structure, 31, 2023
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7KQX
| MIF Y99C homotrimeric mutant | Descriptor: | GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... | Authors: | Manjula, R, Georgios, P, Lolis, E.J. | Deposit date: | 2020-11-18 | Release date: | 2022-01-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies. Front Mol Biosci, 9, 2022
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