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2I7K
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BU of 2i7k by Molmil
Solution Structure of the Bromodomain of Human BRD7 Protein
Descriptor: Bromodomain-containing protein 7
Authors:Sun, H, Liu, J, Zhang, J, Huang, H, Wu, J, Shi, Y.
Deposit date:2006-08-31
Release date:2007-07-10
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4
Biochem.Biophys.Res.Commun., 358, 2007
6PPA
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BU of 6ppa by Molmil
Crystal structure of the unliganded bromodomain of human BRD7
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 7, PHOSPHATE ION
Authors:Chan, A, Karim, M.R, Zhu, J, Schonbrunn, E.
Deposit date:2019-07-05
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V0Q
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BU of 6v0q by Molmil
Crystal structure of the bromodomain of human BRD7 bound to TG003
Descriptor: (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 7, ...
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V16
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BU of 6v16 by Molmil
Crystal structure of the bromodomain of human BRD7 bound to TP472
Descriptor: 1,2-ETHANEDIOL, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, Bromodomain-containing protein 7, ...
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1H
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BU of 6v1h by Molmil
Crystal structure of the bromodomain of human BRD7 bound to bromosporine
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 7, Bromosporine
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1F
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BU of 6v1f by Molmil
Crystal structure of the bromodomain of human BRD7 bound to BI9564
Descriptor: 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 7
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1E
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BU of 6v1e by Molmil
Crystal structure of the bromodomain of human BRD7 bound to BI7273
Descriptor: 1,2-ETHANEDIOL, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 7
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V17
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BU of 6v17 by Molmil
Crystal structure of the bromodomain of human BRD7 bound to I-BRD9
Descriptor: Bromodomain-containing protein 7, CHLORIDE ION, N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
5MQ1
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BU of 5mq1 by Molmil
Crystal structure of the BRD7 bromodomain in complex with BI-9564
Descriptor: 1,2-ETHANEDIOL, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 7, ...
Authors:Diaz-Saez, L, Martin, L.J, Panagakou, I, Picaud, S, Krojer, T, von Delft, F, Knapp, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K, Structural Genomics Consortium (SGC)
Deposit date:2016-12-19
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the BRD7 bromodomain in complex with BI-9564
To Be Published
5JI8
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BU of 5ji8 by Molmil
Crystal structure of the BRD9 bromodomain and hit 1
Descriptor: 2-amino-1,3-benzothiazole-6-carboxamide, Bromodomain-containing protein 9
Authors:Wang, N, Li, F, Bao, H, Li, J, Wu, J, Ruan, K.
Deposit date:2016-04-22
Release date:2016-06-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains
Chembiochem, 17, 2016
4Z6I
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BU of 4z6i by Molmil
Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand
Descriptor: Bromodomain-containing protein 9, tert-butyl [(2R,3S)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxo-2-phenylpiperidin-3-yl]carbamate
Authors:Tallant, C, Structural Genomics Consortium (SGC), Clark, P.G.K, Vieira, L.C.C, Newman, J.A, Krojer, T, Nunez-Alonso, G, Picaud, S, Fedorov, O, Dixon, D.J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Knapp, S.
Deposit date:2015-04-05
Release date:2015-05-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Z6H
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BU of 4z6h by Molmil
Crystal structure of BRD9 bromodomain in complex with a valerolactam quinolone ligand
Descriptor: 1,4-dimethyl-7-(2-oxopiperidin-1-yl)quinolin-2(1H)-one, Bromodomain-containing protein 9
Authors:Tallant, C, Structural Genomics Consortium (SGC), Clark, P.G.K, Vieira, L.C.C, Krojer, T, Nunez-Alonso, G, Picaud, S, Fedorov, O, Dixon, D.J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Knapp, S.
Deposit date:2015-04-05
Release date:2015-05-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Angew.Chem.Int.Ed.Engl., 54, 2015
6HM0
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BU of 6hm0 by Molmil
Crystal structure of human BRD9 bromodomain in complex with a PROTAC
Descriptor: (2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 9
Authors:Hughes, S.J, Zoppi, V, Ciulli, A.
Deposit date:2018-09-11
Release date:2019-01-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.
J.Med.Chem., 62, 2019
6YQS
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BU of 6yqs by Molmil
BRD9 with methylpiperazinyl-benzyl-amino-dimethylpyridazinone
Descriptor: 2,4-dimethyl-5-[[2-(4-methylpiperazin-1-yl)phenyl]methylamino]pyridazin-3-one, Bromodomain-containing protein 9
Authors:Chung, C.
Deposit date:2020-04-18
Release date:2021-03-24
Method:X-RAY DIFFRACTION (1.683 Å)
Cite:Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
J.Med.Chem., 63, 2020
6YQR
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BU of 6yqr by Molmil
BRD9 with Biphenyl-methylamino-dimethylpyridazinone
Descriptor: 2,4-dimethyl-5-[(2-phenylphenyl)methylamino]pyridazin-3-one, Bromodomain-containing protein 9
Authors:Chung, C.
Deposit date:2020-04-18
Release date:2021-03-24
Method:X-RAY DIFFRACTION (1.684 Å)
Cite:Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
J.Med.Chem., 63, 2020
6YQZ
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BU of 6yqz by Molmil
N-terminal domain of BRD4 with biphenyl-methyamino-dimethylpyridazinone
Descriptor: 1,2-ETHANEDIOL, 2,4-dimethyl-5-[(2-phenylphenyl)methylamino]pyridazin-3-one, Bromodomain-containing protein 4
Authors:Chung, C.
Deposit date:2020-04-18
Release date:2021-03-24
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
J.Med.Chem., 63, 2020
6YQW
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BU of 6yqw by Molmil
BRD9 with 4-chloro-2-methyl-methylamino-pyridazinone
Descriptor: 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one, Bromodomain-containing protein 9
Authors:Chung, C.
Deposit date:2020-04-18
Release date:2021-04-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
J.Med.Chem., 63, 2020
6V0S
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BU of 6v0s by Molmil
Crystal structure of the bromodomain of human BRD9 bound to TG003
Descriptor: (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one, Bromodomain-containing protein 9
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V0X
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BU of 6v0x by Molmil
Crystal structure of the bromodomain of human BRD9 bound to sunitinib
Descriptor: Bromodomain-containing protein 9, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide
Authors:Karim, M.R, Chan, A, Zhu, J.Y, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1K
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BU of 6v1k by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to BI7273
Descriptor: 1,2-ETHANEDIOL, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 4
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1L
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BU of 6v1l by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to BI9564
Descriptor: 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 4
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1B
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BU of 6v1b by Molmil
Crystal structure of the bromodomain of human BRD9 bound to I-BRD9
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 9, N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V14
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BU of 6v14 by Molmil
Crystal structure of the bromodomain of human BRD9 bound to TP472
Descriptor: 1,2-ETHANEDIOL, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, Bromodomain-containing protein 9
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1U
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BU of 6v1u by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to TP-472
Descriptor: 1,2-ETHANEDIOL, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, Bromodomain-containing protein 4
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-21
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6UZF
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BU of 6uzf by Molmil
Crystal structure of the unliganded bromodomain of human BRD9
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 9, DIMETHYL SULFOXIDE, ...
Authors:Karim, M.R, Chan, A, Schonbrunn, E.
Deposit date:2019-11-15
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020

 

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