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4KV4
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BU of 4kv4 by Molmil
Brd4 Bromodomain 2 in Complex with Acetylated Rel Peptide
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bromodomain-containing protein 4, Rel Peptide
Authors:Zhang, H, Nair, S.K.
Deposit date:2013-05-22
Release date:2013-06-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Oncogene, 33, 2014
5UVW
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BU of 5uvw by Molmil
BRD4_Bromodomain1-A1376855
Descriptor: Bromodomain-containing protein 4, N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide, SULFATE ION
Authors:Park, C.H.
Deposit date:2017-02-20
Release date:2017-06-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:BRD4_Bromodomain1-A1376855
To Be Published
4KV1
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BU of 4kv1 by Molmil
Crystal Structure of Brd4 Bromodomain 1 in Complex with Acetylated Rel Peptide
Descriptor: Bromodomain-containing protein 4, Rel peptide
Authors:Zhang, H, Nair, S.K.
Deposit date:2013-05-22
Release date:2013-06-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Oncogene, 33, 2014
5WMG
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BU of 5wmg by Molmil
N-terminal bromodomain of BRD4 in complex with OTX-015
Descriptor: 1,2-ETHANEDIOL, 4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl}benzoic acid, Bromodomain-containing protein 4
Authors:Zhang, Y.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov, 8, 2018
5WMD
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BU of 5wmd by Molmil
N-terminal bromodomain of BRD4 in complex with OTX-015
Descriptor: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide, Bromodomain-containing protein 4
Authors:Zhang, Y.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov, 8, 2018
5WMA
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BU of 5wma by Molmil
N-terminal bromodomain of BRD4 in complex with PLX5981
Descriptor: 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, Bromodomain-containing protein 4
Authors:Zhang, Y.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov, 8, 2018
8GQ0
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BU of 8gq0 by Molmil
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with STL233497
Descriptor: Bromodomain-containing protein 4, FORMIC ACID, GLYCEROL, ...
Authors:Park, T.H, Lee, B.I.
Deposit date:2022-08-27
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study.
Sci Rep, 13, 2023
8GPZ
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BU of 8gpz by Molmil
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with C239-0012
Descriptor: 3-methyl-6-(4-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, Bromodomain-containing protein 4, FORMIC ACID, ...
Authors:Park, T.H, Lee, B.I.
Deposit date:2022-08-27
Release date:2023-01-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.528 Å)
Cite:Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study.
Sci Rep, 13, 2023
3JVJ
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BU of 3jvj by Molmil
Crystal structure of the bromodomain 1 in mouse Brd4
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL
Authors:Vollmuth, F, Blankenfeldt, W, Geyer, M.
Deposit date:2009-09-17
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution
J.Biol.Chem., 284, 2009
3JVM
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BU of 3jvm by Molmil
Crystal structure of bromodomain 2 of mouse Brd4
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Bromodomain-containing protein 4
Authors:Vollmuth, F, Blankenfeldt, W, Geyer, M.
Deposit date:2009-09-17
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution
J.Biol.Chem., 284, 2009
3JVL
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BU of 3jvl by Molmil
Crystal structure of bromodomain 2 of mouse Brd4
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Bromodomain-containing protein 4
Authors:Vollmuth, F, Blankenfeldt, W, Geyer, M.
Deposit date:2009-09-17
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution
J.Biol.Chem., 284, 2009
3JVK
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BU of 3jvk by Molmil
Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, histone H3.3 peptide
Authors:Vollmuth, F, Blankenfeldt, W, Geyer, M.
Deposit date:2009-09-17
Release date:2009-10-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution
J.Biol.Chem., 284, 2009
5I88
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BU of 5i88 by Molmil
BRD4 in complex with Cpd4 ((E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide)
Descriptor: 1,2-ETHANEDIOL, 3-{6-[(2E)-but-2-en-1-yl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-N,N-dimethylbenzamide, Bromodomain-containing protein 4, ...
Authors:Murray, J.M.
Deposit date:2016-02-18
Release date:2016-10-12
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J.Med.Chem., 59, 2016
5I80
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BU of 5i80 by Molmil
BRD4 in complex with Cpd2 (N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ...
Authors:Murray, J.M.
Deposit date:2016-02-18
Release date:2016-10-12
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.4501 Å)
Cite:Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
J.Med.Chem., 59, 2016
7EHY
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BU of 7ehy by Molmil
BRD4-BD1 in complex with LT-448-138
Descriptor: 1-[2,4-dimethyl-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-30
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:BRD4-BD1 in complex with LT-642-602
To Be Published
4DON
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BU of 4don by Molmil
Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon
Descriptor: 3-methyl-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4
Authors:Xiong, B, Cao, D.Y, Chen, W.Y, Chen, T.T, Xu, Y.C, Shen, J.K.
Deposit date:2012-02-09
Release date:2013-02-13
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon
To be Published
7WWZ
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BU of 7wwz by Molmil
BRD4-BD1 complexed with NEO2734
Descriptor: 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one, Isoform C of Bromodomain-containing protein 4
Authors:Zeng, L, Lei, J.D.
Deposit date:2022-02-14
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer.
Oncogene, 41, 2022
7EHW
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BU of 7ehw by Molmil
BRD4-BD1 in complex with LT-642-602
Descriptor: 1-[4-ethyl-2-methyl-5-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-30
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:BRD4-BD1 in complex with LT-642-602
To Be Published
7EIG
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BU of 7eig by Molmil
BRD4-BD1 in complex with LT-730-903
Descriptor: 1-[5-(5-azanyl-1H-benzimidazol-2-yl)-2-methyl-4-phenyl-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
Authors:Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
Deposit date:2021-03-31
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:BRD4-BD1 in complex with LT-730-903
To Be Published
7V1U
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BU of 7v1u by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide
Authors:Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y.
Deposit date:2021-08-06
Release date:2022-08-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
7V2J
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BU of 7v2j by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 33
Descriptor: Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-4-methoxy-benzenesulfonamide
Authors:Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y.
Deposit date:2021-08-09
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
7USK
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BU of 7usk by Molmil
BRD4-BD2 Ligand free
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE
Authors:Jayasinghe, T.D, Ronning, D.R.
Deposit date:2022-04-25
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma.
J Control Release, 354, 2023
7USJ
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BU of 7usj by Molmil
BRD4-BD2 in complex with SF2523
Descriptor: 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4
Authors:Jayasinghe, T.D, Ronning, D.R.
Deposit date:2022-04-25
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma.
J Control Release, 354, 2023
6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
Descriptor: Bromodomain-containing protein 4, FOXO3a peptide
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
4QR5
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BU of 4qr5 by Molmil
Brd4 Bromodomain 1 complex with its novel inhibitors
Descriptor: Bromodomain-containing protein 4, N-[3-(cyclopentylsulfamoyl)-5-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]cyclopropanecarboxamide
Authors:Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C.
Deposit date:2014-06-30
Release date:2015-07-01
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization
J.Med.Chem., 58, 2015

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