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7BDX
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BU of 7bdx by Molmil
Armadillo domain of HSF2BP in complex with BRCA2 peptide
Descriptor: Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein, MAGNESIUM ION
Authors:Le Du, M.H, Zinn-Justin, S, Ghouil, R, Miron, S, Legrand, P.
Deposit date:2020-12-22
Release date:2021-07-07
Last modified:2022-07-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Nat Commun, 12, 2021
3EU7
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BU of 3eu7 by Molmil
Crystal Structure of a PALB2 / BRCA2 complex
Descriptor: 19meric peptide from Breast cancer type 2 susceptibility protein, GLYCEROL, Partner and localizer of BRCA2
Authors:Oliver, A.W, Pearl, L.H.
Deposit date:2008-10-09
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for recruitment of BRCA2 by PALB2
Embo Rep., 10, 2009
1IYJ
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BU of 1iyj by Molmil
STRUCTURE OF A BRCA2-DSS1 COMPLEX
Descriptor: Deleted in split hand/split foot protein 1, breast cancer susceptibility
Authors:Pavletich, N.P, Jeffrey, P.D, Yang, H.J.
Deposit date:2002-08-28
Release date:2002-10-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
1MIU
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BU of 1miu by Molmil
Structure of a BRCA2-DSS1 complex
Descriptor: Breast Cancer type 2 susceptibility protein, Deleted in split hand/split foot protein 1, MERCURY (II) ION
Authors:Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P.
Deposit date:2002-08-23
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
Science, 297, 2002
1N0W
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BU of 1n0w by Molmil
Crystal structure of a RAD51-BRCA2 BRC repeat complex
Descriptor: 1,2-ETHANEDIOL, ARTIFICIAL GLY-SER-MSE-GLY PEPTIDE, Breast cancer type 2 susceptibility protein, ...
Authors:Pellegrini, L, Yu, D.S, Lo, T, Anand, S, Lee, M, Blundell, T.L, Venkitaraman, A.R.
Deposit date:2002-10-15
Release date:2002-11-27
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Nature, 420, 2002
7LDG
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BU of 7ldg by Molmil
Crystal structure of the MEILB2-BRCA2 complex
Descriptor: Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein
Authors:Nandakumar, J, Pendlebury, D.F.
Deposit date:2021-01-13
Release date:2021-08-11
Last modified:2021-08-25
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites.
Nat.Struct.Mol.Biol., 28, 2021
8PBD
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BU of 8pbd by Molmil
RAD51 filament on dsDNA bound by the BRCA2 c-terminus
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Breast cancer type 2 susceptibility protein, CALCIUM ION, ...
Authors:Appleby, R, Pellegrini, L.
Deposit date:2023-06-09
Release date:2023-11-15
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.
Nat Commun, 14, 2023
8PBC
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BU of 8pbc by Molmil
RAD51 filament on ssDNA bound by the BRCA2 c-terminus
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Breast cancer type 2 susceptibility protein, CALCIUM ION, ...
Authors:Appleby, R, Pellegrini, L.
Deposit date:2023-06-09
Release date:2023-11-15
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.
Nat Commun, 14, 2023
1MJE
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BU of 1mje by Molmil
STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX
Descriptor: 5'-D(P*TP*TP*TP*TP*TP*T)-3', Deleted in split hand/split foot protein 1, breast cancer 2
Authors:Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P.
Deposit date:2002-08-27
Release date:2002-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
6GY2
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BU of 6gy2 by Molmil
Crystal structure of human Plk1-PBD in complex with WSSSLATPPTLSSpTVLI phosphopeptide from BRCA2
Descriptor: GLYCEROL, Phosphopeptide of BRCA2, Serine/threonine-protein kinase PLK1
Authors:Miron, S, Ropars, V, Zinn-Justin, S.
Deposit date:2018-06-28
Release date:2019-07-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Nat Commun, 11, 2020
8R2G
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BU of 8r2g by Molmil
Crystal structure of a BRCA2-DMC1 complex
Descriptor: Breast cancer type 2 susceptibility protein, Meiotic recombination protein DMC1/LIM15 homolog
Authors:Dunce, J.M, Davies, O.R.
Deposit date:2023-11-05
Release date:2023-11-22
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal structure of a BRCA2-DMC1 complex
To Be Published
2W18
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BU of 2w18 by Molmil
Crystal structure of the C-terminal WD40 domain of human PALB2
Descriptor: GLYCEROL, PARTNER AND LOCALIZER OF BRCA2
Authors:Oliver, A.W, Pearl, L.H.
Deposit date:2008-10-15
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10, 2009
8A50
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BU of 8a50 by Molmil
Crystal structure of HSF2BP-ALPHA1 tetramer
Descriptor: Heat shock factor 2-binding protein, PHOSPHATE ION
Authors:Miron, S, Legrand, P, Ropars, V, Ghouil, R, Zinn-Justin, S.
Deposit date:2022-06-13
Release date:2023-07-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.484 Å)
Cite:BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.
Sci Adv, 9, 2023
8A51
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BU of 8a51 by Molmil
Crystal structure of HSF2BP-BRME1 complex
Descriptor: 1,2-ETHANEDIOL, Break repair meiotic recombinase recruitment factor 1, CHLORIDE ION, ...
Authors:Miron, S, Legrand, P, Ropars, V, Ghouil, R, Zinn-Justin, S.
Deposit date:2022-06-13
Release date:2023-07-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.
Sci Adv, 9, 2023
6XTW
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BU of 6xtw by Molmil
HumRadA33F in complex with peptidic inhibitor 6
Descriptor: DNA repair and recombination protein RadA, SULFATE ION, ~{N}-[2-[(2~{S})-2-[[(1~{S})-1-(4-methoxyphenyl)ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxidanylidene-ethyl]quinoline-2-carboxamide
Authors:Fischer, G, Marsh, M.E, Scott, D.E, Coyne, A.G, Skidmore, J, Abell, C, Hyvonen, M.
Deposit date:2020-01-16
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol, 28, 2021
6TW3
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BU of 6tw3 by Molmil
HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera
Descriptor: (2~{S})-1-[(2~{S})-2-[(3-azanylnaphthalen-2-yl)carbonylamino]-3-(1~{H}-imidazol-4-yl)propanoyl]-~{N}-[(2~{S})-1-azanyl-1-oxidanylidene-propan-2-yl]pyrrolidine-2-carboxamide, DNA repair and recombination protein RadA, PHOSPHATE ION
Authors:Marsh, M.E, Fischer, G, Scott, D.E, Coyne, A.G, Skidmore, J, Abell, C, Hyvonen, M.
Deposit date:2020-01-12
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.352 Å)
Cite:A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol, 28, 2021
6TW4
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BU of 6tw4 by Molmil
HumRadA22F in complex with compound 6
Descriptor: CALCIUM ION, DNA repair and recombination protein RadA, ~{N}-[2-[(2~{S})-2-[[(1~{S})-1-(4-methoxyphenyl)ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxidanylidene-ethyl]quinoline-2-carboxamide
Authors:Marsh, M.E, Scott, D.E, Coyne, A.G, Skidmore, J, Abell, C, Hyvonen, M.
Deposit date:2020-01-12
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol, 28, 2021
6TW9
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BU of 6tw9 by Molmil
HumRadA22F in complex with CAM833
Descriptor: CALCIUM ION, DNA repair and recombination protein RadA, GLYCEROL, ...
Authors:Fischer, G, Marsh, M.E, Scott, D.E, Coyne, A.G, Skidmore, J, Abell, C, Hyvonen, M.
Deposit date:2020-01-12
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol, 28, 2021
6TV3
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BU of 6tv3 by Molmil
HumRadA1 in complex with 3-amino-2-naphthoic acid
Descriptor: 3-azanylnaphthalene-2-carboxylic acid, DNA repair and recombination protein RadA, GLYCEROL, ...
Authors:Marsh, M.E, Hyvonen, M.
Deposit date:2020-01-08
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol, 28, 2021
1PZN
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BU of 1pzn by Molmil
Rad51 (RadA)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA repair and recombination protein rad51, GLYCEROL, ...
Authors:Shin, D.S, Tainer, J.A.
Deposit date:2003-07-12
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Full-length archaeal Rad51 structure and mutants: Mechanisms for RAD51 assembly and control by BRCA2
Embo J., 22, 2003
6QZV
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BU of 6qzv by Molmil
DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2
Descriptor: Dipeptidyl peptidase 9, MET-PRO
Authors:Ross, B, Geiss-Friedlander, R, Huber, R.
Deposit date:2019-03-12
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Biorxiv, 2020
6QZW
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BU of 6qzw by Molmil
DPP8 bound to a dipeptide (MP) from the N-terminus of BRCA2
Descriptor: Dipeptidyl peptidase 8, MET-PRO, SODIUM ION
Authors:Ross, B, Geiss-Friedlander, R, Huber, R.
Deposit date:2019-03-12
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Biorxiv, 2020
6WCD
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BU of 6wcd by Molmil
Crystal Structure of Xenopus laevis APE2 Catalytic Domain
Descriptor: 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Wojtaszek, J.L, Wallace, B.D, Williams, R.S.
Deposit date:2020-03-30
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Mol.Cell, 78, 2020
5FPK
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BU of 5fpk by Molmil
MONOMERIC RADA IN COMPLEX WITH FATA TETRAPEPTIDE
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHTG PEPTIDE, PHOSPHATE ION
Authors:Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
Deposit date:2015-12-01
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.343 Å)
Cite:Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016
5FOT
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BU of 5fot by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH FHTU TETRAPEPTIDE
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHTU PEPTIDE, PHOSPHATE ION
Authors:Scott, D.E, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
Deposit date:2015-11-26
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.189 Å)
Cite:Structure Activity Relationship of the Peptide Binding Motif Mediating the Rad51:Brca2 Protein-Protein Interaction.
FEBS Lett., 590, 2016

 

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