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2K7S
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BU of 2k7s by Molmil
Human ARNT C-Terminal PAS Domain, 3 Residue IB slip
Descriptor: Aryl hydrocarbon receptor nuclear translocator
Authors:Evans, M.R, Card, P.B, Gardner, K.H.
Deposit date:2008-08-20
Release date:2009-01-20
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:ARNT PAS-B has a fragile native state structure with an alternative beta-sheet register nearby in sequence space
Proc.Natl.Acad.Sci.USA, 106, 2009
2A24
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BU of 2a24 by Molmil
HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain protein 1
Authors:Card, P.B, Erbel, P.J, Gardner, K.H.
Deposit date:2005-06-21
Release date:2006-01-17
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
J.Mol.Biol., 353, 2005
1X0O
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BU of 1x0o by Molmil
human ARNT C-terminal PAS domain
Descriptor: Aryl hydrocarbon receptor nuclear translocator
Authors:Card, P.B, Erbel, P.J, Gardner, K.H.
Deposit date:2005-03-25
Release date:2005-10-25
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural Basis of ARNT PAS-B Dimerization: Use of a Common Beta-sheet Interface for Hetero- and Homodimerization.
J.Mol.Biol., 353, 2005
5SY5
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BU of 5sy5 by Molmil
Crystal Structure of the Heterodimeric NPAS1-ARNT Complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 1
Authors:Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
5SY7
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BU of 5sy7 by Molmil
Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA
Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
Authors:Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
7XHV
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BU of 7xhv by Molmil
Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA
Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ...
Authors:Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L.
Deposit date:2022-04-10
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.996 Å)
Cite:Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
4EQ1
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BU of 4eq1 by Molmil
Crystal Structure of the ARNT PAS-B homodimer
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Aryl hydrocarbon receptor nuclear translocator
Authors:Gardner, K.H, Key, J.M.
Deposit date:2012-04-17
Release date:2013-04-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules.
Acs Chem.Biol., 8, 2013
4H6J
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BU of 4h6j by Molmil
Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.
Descriptor: ARYL HYDROCARBON NUCLEAR TRANSLOCATOR, HYPOXIA INDUCIBLE FACTOR 1-ALPHA
Authors:Cardoso, R, Love, R.A, Nilsson, C, Bergqvist, S, Nowlin, D, Yan, J, Liu, K, Zhu, J, Chen, P, Deng, Y.-L, Dyson, H.J, Greig, M.J, Brooun, A.
Deposit date:2012-09-19
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
5Y7Y
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BU of 5y7y by Molmil
Crystal structure of AhRR/ARNT complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL
Authors:Sakurai, S, Shimizu, T, Ohto, U.
Deposit date:2017-08-18
Release date:2017-09-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
J. Biol. Chem., 292, 2017
7XI4
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BU of 7xi4 by Molmil
Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA
Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), ...
Authors:Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L.
Deposit date:2022-04-12
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (4.707 Å)
Cite:Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
2B02
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BU of 2b02 by Molmil
Crystal Structure of ARNT PAS-B Domain
Descriptor: Aryl hydrocarbon receptor nuclear translocator
Authors:Lee, J, Botuyan, M.V, Nomine, Y, Ohh, M, Thompson, J.R, Mer, G.
Deposit date:2005-09-12
Release date:2006-10-24
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure and Binding Properties of ARNT PAS-B Heterodimerization Domain
To be Published
2HV1
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BU of 2hv1 by Molmil
HADDOCK structure of ARNT PAS-B Homodimer
Descriptor: Aryl hydrocarbon receptor nuclear translocator
Authors:Card, P.B, Gardner, K.H.
Deposit date:2006-07-27
Release date:2007-08-07
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Practical aspects of using paramagnetic relaxation enhancements for protein docking: Application to the ARNT PAS-B homodimer
To be Published
6X28
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BU of 6x28 by Molmil
Crystal structure of PT2243 bound to HIF2a-B*:ARNT-B* complex
Descriptor: (1R)-4-(3,5-difluorophenoxy)-7-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2020-05-20
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of PT2243 bound to HIF2-PasB*:ARNT-PasB* complex
To Be Published
6X37
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BU of 6x37 by Molmil
Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex
Descriptor: 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2020-05-21
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6X3D
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BU of 6x3d by Molmil
Crystal structure of PT3388 bound to HIF2a-B*:ARNT-B* complex
Descriptor: (6R,7S)-4-[(3,3-difluorocyclobutyl)oxy]-6-fluoro-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2020-05-21
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of PT3388 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6X21
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BU of 6x21 by Molmil
Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex
Descriptor: 1-(3-bromo-5-fluorophenoxy)-4-[(difluoromethyl)sulfonyl]-2-nitrobenzene, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2020-05-19
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6X2H
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BU of 6x2h by Molmil
Crystal structure of PT2863 bound to HIF2a-B*:ARNT-B* complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, cis-3-({(1S)-7-[dihydroxy(trifluoromethyl)-lambda~4~-sulfanyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)cyclobutane-1-carbonitrile
Authors:Du, X.
Deposit date:2020-05-20
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of PT2863 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6D09
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BU of 6d09 by Molmil
Crystal structure of PT2440 bound to HIF2a-B*:ARNT-B* complex
Descriptor: 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2018-04-10
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6D0C
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BU of 6d0c by Molmil
Crystal structure of HIF2a-B*:ARNT-B* complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Du, X.
Deposit date:2018-04-10
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6CZW
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BU of 6czw by Molmil
Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol
Authors:Du, X.
Deposit date:2018-04-09
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex
To Be Published
6D0B
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BU of 6d0b by Molmil
Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline
Authors:Du, X.
Deposit date:2018-04-10
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of PT1614 bound to HIF2a-B*:ARNT-B* complex
To Be Published
4PKY
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BU of 4pky by Molmil
ARNT/HIF transcription factor/coactivator complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, SULFATE ION, ...
Authors:Tomchick, D.R, Partch, C.L, Gardner, K.H.
Deposit date:2014-05-15
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization.
J.Biol.Chem., 290, 2015
4LPZ
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BU of 4lpz by Molmil
ARNT transcription factor/coactivator complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Transforming acidic coiled-coil-containing protein 3
Authors:Guo, Y, Scheuermann, T.H, Gardner, K.H.
Deposit date:2013-07-16
Release date:2014-07-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.
J.Biol.Chem., 290, 2015
5F15
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BU of 5f15 by Molmil
Crystal Structure of ArnT from Cupriavidus metallidurans bound to Undecaprenyl phosphate
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-4-deoxy-L-arabinose (L-Ara4N) transferase, CHLORIDE ION, ...
Authors:Petrou, V.I, Clarke, O.B, Tomasek, D, Banerjee, S, Rajashankar, K.R, Mancia, F, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2015-11-30
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation.
Science, 351, 2016
5EZM
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BU of 5ezm by Molmil
Crystal Structure of ArnT from Cupriavidus metallidurans in the apo state
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferases of PMT family, CHLORIDE ION, ...
Authors:Petrou, V.I, Clarke, O.B, Tomasek, D, Banerjee, S, Rajashankar, K.R, Mancia, F, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2015-11-26
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation.
Science, 351, 2016

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