PDB: 10 resultsInfo pagesStatus searchChemie searchBIRD

---

4OGR	crystal structure of P-TEFb complex with AFF4 and Tat Descriptor: ADENOSINE, AF4/FMR2 family member 4, Cyclin-T1, ... Authors: Schulze-Gahmen, U, Alber, T. Deposit date: 2014-01-16 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife, 3, 2014
6R80	Structure of AFF4 C-terminal homology domain Descriptor: AF4/FMR2 family member 4 Authors: Chen, Y, Cramer, P. Deposit date: 2019-03-30 Release date: 2019-06-12 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. J.Biol.Chem., 294, 2019
4IMY	The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat Descriptor: ADENOSINE MONOPHOSPHATE, AF4/FMR2 family member 4, Cyclin-T1, ... Authors: Alber, T, Schulze-Gahmen, U. Deposit date: 2013-01-03 Release date: 2013-03-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.94 Å) Cite: The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat. Elife, 2, 2013
4OR5	Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 Descriptor: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... Authors: Gu, J, Babayeva, N.D, Suwa, Y, Baranovskiy, A.G, Price, D.H, Tahirov, T.H. Deposit date: 2014-02-10 Release date: 2014-04-16 Last modified: 2014-06-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle, 13, 2014
6K7P	Crystal structure of human AFF4-THD domain Descriptor: AF4/FMR2 family member 4 Authors: Tang, D, Xue, Y, Li, S, Cheng, W, Duan, J, Wang, J, Qi, S. Deposit date: 2019-06-08 Release date: 2020-03-11 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription. Cell Discov, 6, 2020
5JW9	The Crystal Structure of ELL2 Oclludin Domain and AFF4 peptide Descriptor: AF4/FMR2 family member 4, RNA polymerase II elongation factor ELL2 Authors: Qi, S, Hurley, J.H. Deposit date: 2016-05-11 Release date: 2017-02-08 Method: X-RAY DIFFRACTION (2.003 Å) Cite: Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nat Commun, 8, 2017
5L1Z	TAR complex with HIV-1 Tat-AFF4-P-TEFb Descriptor: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... Authors: Schulze-Gahmen, U, Hurley, J. Deposit date: 2016-07-29 Release date: 2016-10-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (5.9 Å) Cite: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife, 5, 2016
6KN5	Crystal structure of AFF4 C-terminal domain Descriptor: AF4/FMR2 family member 4 Authors: Chen, L.J, Yang, W.S, Xu, R.M. Deposit date: 2019-08-03 Release date: 2020-07-08 Last modified: 2022-03-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. Commun Biol, 3, 2020
6CYT	HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb Descriptor: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... Authors: Schulze Gahmen, U, Hurley, J.H. Deposit date: 2018-04-06 Release date: 2018-12-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6D2U	Solution structure of a ultra-high affinity macrocycle bound to HIV-1 TAR RNA Descriptor: DAB-VAL-ARG-THR-ARG-LYS-GLY-ARG-ARG-ILE-NOR-ILE-DPR-PRO, RNA (29-MER) Authors: Shortridge, M.D, Varani, G. Deposit date: 2018-04-13 Release date: 2018-12-12 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb. Nucleic Acids Res., 47, 2019