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6KM7
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BU of 6km7 by Molmil
The structural basis for the internal interaction in RBBP5
Descriptor: HEXAETHYLENE GLYCOL, NONAETHYLENE GLYCOL, Retinoblastoma-binding protein 5, ...
Authors:Han, J, Li, T, Chen, Y.
Deposit date:2019-07-31
Release date:2019-10-02
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.
Nucleic Acids Res., 47, 2019
6N31
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BU of 6n31 by Molmil
WD repeats of human WDR12
Descriptor: Ribosome biogenesis protein WDR12, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Tempel, W, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2018-11-14
Release date:2018-12-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:WD repeats of human WDR12
To Be Published
6QTS
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BU of 6qts by Molmil
Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTR
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BU of 6qtr by Molmil
Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTT
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BU of 6qtt by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor homolog
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTQ
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BU of 6qtq by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTX
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BU of 6qtx by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with a flowering transcription factor homolog
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTV
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BU of 6qtv by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with an atypical bHLH transcription factor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTO
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BU of 6qto by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor
Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTW
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BU of 6qtw by Molmil
Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor
Descriptor: Cryptochrome-1, E3 ubiquitin-protein ligase COP1, GLYCEROL, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6QTU
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BU of 6qtu by Molmil
Crystal structure of Arabidopsis WD40 domain in complex with a BBX transcription factor
Descriptor: B-box zinc finger protein 24, E3 ubiquitin-protein ligase COP1, GLYCEROL, ...
Authors:Hothorn, M, Lau, K.
Deposit date:2019-02-25
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs.
Embo J., 38, 2019
6R60
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BU of 6r60 by Molmil
asymmetric antiparallel assembly of two 5-bladed beta-propeller fragments
Descriptor: WD-40 repeat protein
Authors:Afanasieva, E, Lupas, A.N, Hartmann, M.D.
Deposit date:2019-03-26
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural diversity of oligomeric beta-propellers with different numbers of identical blades.
Elife, 8, 2019
6R5Z
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BU of 6r5z by Molmil
9-bladed beta-propeller formed by three 3-bladed fragments
Descriptor: 9-bladed beta-propeller formed by three 3-bladed fragments
Authors:Martin, J, Lupas, A.N, Hartmann, M.D.
Deposit date:2019-03-26
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural diversity of oligomeric beta-propellers with different numbers of identical blades.
Elife, 8, 2019
6R5X
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BU of 6r5x by Molmil
8-bladed beta-propeller formed by four 2-bladed fragments
Descriptor: WD-40 repeat protein
Authors:Martin, J, Lupas, A.N, Hartmann, M.D.
Deposit date:2019-03-25
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural diversity of oligomeric beta-propellers with different numbers of identical blades.
Elife, 8, 2019
6R5Y
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BU of 6r5y by Molmil
8-bladed beta-propeller formed by two 4-bladed fragments
Descriptor: WD-40 repeat protein, ZINC ION
Authors:Martin, J, Lupas, A.N, Hartmann, M.D.
Deposit date:2019-03-25
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural diversity of oligomeric beta-propellers with different numbers of identical blades.
Elife, 8, 2019
6SFC
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BU of 6sfc by Molmil
EED in complex with a methyl-thiazole
Descriptor: CALCIUM ION, N-(1,3-benzodioxol-4-ylmethyl)-4-methyl-5-(1-methylpyrazol-3-yl)-1,3-thiazol-2-amine, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
Authors:Read, J.A.
Deposit date:2019-08-01
Release date:2019-09-25
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Acs Chem.Biol., 14, 2019
6SFB
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BU of 6sfb by Molmil
EED in complex with a triazolopyrimidine
Descriptor: GLYCEROL, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED
Authors:Read, J.A.
Deposit date:2019-08-01
Release date:2019-09-25
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Acs Chem.Biol., 14, 2019
6U80
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BU of 6u80 by Molmil
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Descriptor: 5-bromo-N-(4-hydroxy[1,1'-biphenyl]-3-yl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5
Authors:Zhao, B, Wang, F.
Deposit date:2019-09-04
Release date:2019-12-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019
7KLJ
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BU of 7klj by Molmil
Crystal structure of the WD-repeat domain of human KIF21A
Descriptor: 1,2-ETHANEDIOL, Isoform 2 of Kinesin-like protein KIF21A, UNKNOWN ATOM OR ION
Authors:Zeng, H, Dong, A, Loppnau, P, Hutchinson, A, Seitova, A, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2020-10-30
Release date:2020-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal structure of the WD-repeat domain of human KIF21A
To be Published
7KXT
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BU of 7kxt by Molmil
Crystal structure of human EED
Descriptor: 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION
Authors:Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2020-12-04
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
J.Med.Chem., 64, 2021
7MT1
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BU of 7mt1 by Molmil
Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)
Descriptor: GLYCEROL, Platelet-activating factor acetylhydrolase IB subunit beta, UNKNOWN ATOM OR ION
Authors:Hutchinson, A, Seitova, A, Dong, A, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2021-05-12
Release date:2021-06-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)
To Be Published
7MSB
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BU of 7msb by Molmil
Structure of EED bound to EEDi-4259
Descriptor: (9aM,12aS)-12-{[(5-fluoro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,11,12a-tetraazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, Polycomb protein EED
Authors:Petrunak, E, Stuckey, J.
Deposit date:2021-05-11
Release date:2021-10-20
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
J.Med.Chem., 64, 2021
7MSD
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BU of 7msd by Molmil
Structure of EED bound to EEDi-6068
Descriptor: (9aP,12aR)-4-(2,2-difluoropropyl)-12-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, FORMIC ACID, Polycomb protein EED
Authors:Petrunak, E, Stuckey, J.
Deposit date:2021-05-11
Release date:2021-10-20
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
J.Med.Chem., 64, 2021
6UFX
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BU of 6ufx by Molmil
WD repeat-containing protein 5 complexed with N-[(3,5-dimethoxyphenyl)methyl]-4'-fluoro-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-2'-methyl[1,1'-biphenyl]-3-carboxamide (compound 13)
Descriptor: N-[(3,5-dimethoxyphenyl)methyl]-4'-fluoro-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-2'-methyl[1,1'-biphenyl]-3-carboxamide, WD repeat-containing protein 5
Authors:Rietz, T.A, Fesik, S.W, Zhao, B.
Deposit date:2019-09-25
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.015 Å)
Cite:Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J.Med.Chem., 63, 2020
6U5Y
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BU of 6u5y by Molmil
Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Descriptor: 3-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-5-(1-cyanocyclobutyl)-2-hydroxy-N-methylbenzamide, WD repeat-containing protein 5
Authors:Zhao, B, Wang, F.
Deposit date:2019-08-28
Release date:2019-12-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.532 Å)
Cite:Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J.Med.Chem., 62, 2019

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PDB entries from 2024-03-13

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