PDB: 392 resultsInfo pagesStatus searchChemie searchBIRD

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7KZT	Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in intermediate state Descriptor: DNA (22-MER), E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, ... Authors: Wang, S.L, Pavletich, N.P. Deposit date: 2020-12-10 Release date: 2021-03-10 Last modified: 2021-03-24 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat.Struct.Mol.Biol., 28, 2021
7M2K	CDC34A-Ubiquitin-2ab inhibitor complex Descriptor: 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 Authors: Ceccarelli, D.F, St-Cyr, D, Tyers, M, Sicheri, F. Deposit date: 2021-03-16 Release date: 2021-11-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex. Sci Adv, 7, 2021
7AI0	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2021-02-10 Method: X-RAY DIFFRACTION (1.559 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7AI1	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2021-02-10 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7AHZ	Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
3FSH	Crystal structure of the ubiquitin conjugating enzyme Ube2g2 bound to the G2BR domain of ubiquitin ligase gp78 Descriptor: Autocrine motility factor receptor, isoform 2, Ubiquitin-conjugating enzyme E2 G2 Authors: Tu, D, Brunger, A.T. Deposit date: 2009-01-09 Release date: 2009-02-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.76 Å) Cite: Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Proc.Natl.Acad.Sci.USA, 106, 2009
6D4P	Ube2D1 in complex with ubiquitin variant Ubv.D1.1 Descriptor: Ubiquitin Variant Ubv.D1.1, Ubiquitin-conjugating enzyme E2 D1 Authors: Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. Deposit date: 2018-04-18 Release date: 2019-07-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
6D68	Ube2G1 in complex with ubiquitin variant Ubv.G1.1 Descriptor: Ubiquitin-conjugating enzyme E2 G1, Ubv.G1.1 Authors: Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. Deposit date: 2018-04-20 Release date: 2019-07-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
6D6I	Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13 Descriptor: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1, Ubv.V1.1 Authors: Ceccarelli, D.F, Garg, P, Keszei, A, Sidhu, S, Sicheri, F. Deposit date: 2018-04-21 Release date: 2019-07-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.551 Å) Cite: Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
6DJW	Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex Descriptor: RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... Authors: Sauve, V, Sung, G, Trempe, J.F, Gehring, K. Deposit date: 2018-05-26 Release date: 2018-07-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.801 Å) Cite: Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
7BXG	MavC-UBE2N-Ub complex Descriptor: MavC, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N Authors: Gao, P, Wang, Y. Deposit date: 2020-04-19 Release date: 2020-05-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.705 Å) Cite: Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors. Nat Commun, 11, 2020
7BBF	Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2 Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 Authors: Kiss, L, Neuhaus, D, James, L.C. Deposit date: 2020-12-17 Release date: 2021-01-27 Last modified: 2021-03-10 Method: X-RAY DIFFRACTION (2.54 Å) Cite: RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination. Nat Commun, 12, 2021
6DJX	Crystal Structure of pParkin-pUb-UbcH7 complex Descriptor: RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... Authors: Sauve, V, Sung, G, Trempe, J.F, Gehring, K. Deposit date: 2018-05-27 Release date: 2018-07-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (4.801 Å) Cite: Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
3H8K	Crystal structure of Ube2g2 complxed with the G2BR domain of gp78 at 1.8-A resolution Descriptor: Autocrine motility factor receptor, isoform 2, Ubiquitin-conjugating enzyme E2 G2 Authors: Kalathur, R.C, Das, R, Li, J, Byrd, R.A, Ji, X. Deposit date: 2009-04-29 Release date: 2009-07-14 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78. Mol.Cell, 34, 2009
3HCU	Crystal structure of TRAF6 in complex with Ubc13 in the C2 space group Descriptor: TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION Authors: Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. Deposit date: 2009-05-06 Release date: 2009-05-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: E2 interaction and dimerization in the crystal structure of TRAF6. Nat.Struct.Mol.Biol., 16, 2009
3HCT	Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group Descriptor: TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION Authors: Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. Deposit date: 2009-05-06 Release date: 2009-05-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: E2 interaction and dimerization in the crystal structure of TRAF6. Nat.Struct.Mol.Biol., 16, 2009
5TUT	UbcH5a-Ub isopeptide conjugate Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 D1 Authors: Sanchez, J.G, Wagner, J.M, Pornillos, O. Deposit date: 2016-11-07 Release date: 2017-11-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.604 Å) Cite: UbcH5a-Ub isopeptide conjugate To be Published
5ULH	Structure of RNF165 in complex with a UbcH5b~Ub conjugate Descriptor: E3 ubiquitin-protein ligase RNF165, GLYCEROL, THIOCYANATE ION, ... Authors: Middleton, A.J, Day, C.L, Wright, J.D. Deposit date: 2017-01-24 Release date: 2017-06-07 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
5ULF	Crystal Structure of a UbcH5b~Ub conjugate Descriptor: GLYCEROL, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 Authors: Middleton, A.J, Day, C.L, Wright, J.D. Deposit date: 2017-01-24 Release date: 2017-06-07 Last modified: 2017-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
5ULK	Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate Descriptor: E3 ubiquitin-protein ligase RNF165, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Middleton, A.J, Day, C.L, Wright, J.D. Deposit date: 2017-01-24 Release date: 2017-06-07 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
3JW0	E2~Ubiquitin-HECT Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 Authors: Kamadurai, H.B, Schulman, B.A. Deposit date: 2009-09-17 Release date: 2010-01-12 Last modified: 2021-10-13 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
3JVZ	E2~Ubiquitin-HECT Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 Authors: Souphron, J, Kamadurai, H.B, Schulman, B.A. Deposit date: 2009-09-17 Release date: 2010-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
5VZW	TRIM23 RING domain in complex with UbcH5-Ub Descriptor: E3 ubiquitin-protein ligase TRIM23, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Pornillos, O, Dawidziak, D. Deposit date: 2017-05-29 Release date: 2017-08-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.278 Å) Cite: Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. Proteins, 85, 2017
3K9P	The crystal structure of E2-25K and ubiquitin complex Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 K Authors: Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. Deposit date: 2009-10-16 Release date: 2010-09-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity J.Biol.Chem., 285, 2010
3K9O	The crystal structure of E2-25K and UBB+1 complex Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 K Authors: Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. Deposit date: 2009-10-16 Release date: 2010-09-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Basis of E2-25K/UBB+1 Interaction for Neurotoxicity of Alzheimer Disease by Proteasome Inhibition To be Published

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