7TKT
 
 | | SthK closed state, cAMP-bound in the presence of detergent | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | | Authors: | Rheinberger, J, Schmidpeter, P.A, Nimigean, C.M. | | Deposit date: | 2022-01-17 | | Release date: | 2022-10-26 | | Last modified: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Nat.Struct.Mol.Biol., 29, 2022
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7TJ5
 | | SthK closed state, cAMP-bound in the presence of POPA | | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | | Authors: | Schmidpeter, P.A, Nimigean, C.M. | | Deposit date: | 2022-01-14 | | Release date: | 2022-10-26 | | Last modified: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Nat.Struct.Mol.Biol., 29, 2022
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6V1Y
 | | Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Octamer | | Descriptor: | (2S)-1-(nonanoyloxy)-3-(phosphonooxy)propan-2-yl tetradecanoate, (3beta,5beta,14beta,17alpha)-cholestan-3-ol, Potassium channel KAT1 | | Authors: | Clark, M.D, Contreras, G.F, Shen, R, Perozo, E. | | Deposit date: | 2019-11-21 | | Release date: | 2020-06-03 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Electromechanical coupling in the hyperpolarization-activated K + channel KAT1.
Nature, 583, 2020
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7T4V
 | | Crystal Structure of cGMP-dependent Protein Kinase | | Descriptor: | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1 | | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | | Deposit date: | 2021-12-10 | | Release date: | 2023-06-14 | | Last modified: | 2023-07-12 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
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7T4T
 | | Crystal Structure of cGMP-dependent Protein Kinase | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | | Deposit date: | 2021-12-10 | | Release date: | 2023-06-14 | | Last modified: | 2023-07-12 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
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7T4U
 | | Crystal Structure of cGMP-dependent Protein Kinase | | Descriptor: | 3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic acid, cGMP-dependent protein kinase 1 | | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | | Deposit date: | 2021-12-10 | | Release date: | 2023-06-14 | | Last modified: | 2023-07-12 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
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7T4W
 | | Crystal Structure of cGMP-dependent Protein Kinase | | Descriptor: | (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1 | | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | | Deposit date: | 2021-12-10 | | Release date: | 2023-06-14 | | Last modified: | 2023-07-12 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Selective small molecule activation of PKG1alpha: structure and function
Commun Biol, 2023
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6VXZ
 | | SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | Authors: | Schmidpeter, P.A.M, Rheinberger, J, Nimigean, C.M. | | Deposit date: | 2020-02-25 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel.
Nat Commun, 11, 2020
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6VY0
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6WEJ
 | | Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs | | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | | Deposit date: | 2020-04-02 | | Release date: | 2020-06-03 | | Last modified: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
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6WEK
 | | Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs | | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | | Deposit date: | 2020-04-02 | | Release date: | 2020-06-03 | | Last modified: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
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6WJG
 | | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | | Descriptor: | DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | | Authors: | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | | Deposit date: | 2020-04-13 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Plos Biol., 18, 2020
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6WJF
 | | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | | Descriptor: | DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | | Authors: | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | | Deposit date: | 2020-04-13 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Plos Biol., 18, 2020
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6WEL
 | | Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs | | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | | Deposit date: | 2020-04-02 | | Release date: | 2020-06-03 | | Last modified: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
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7W5Z
 | | Cryo-EM structure of Tetrahymena thermophila mitochondrial complex IV, composite dimer model | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-oxoglutarate/malate carrier protein, CARDIOLIPIN, ... | | Authors: | Zhou, L, Maldonado, M, Padavannil, A, Letts, J. | | Deposit date: | 2021-11-30 | | Release date: | 2022-04-06 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Structures of Tetrahymena 's respiratory chain reveal the diversity of eukaryotic core metabolism.
Science, 376, 2022
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6CJU
 | | Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cAMP | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK cyclic nucleotide-gated potassium channel | | Authors: | Nimigean, C.M, Rheinberger, J. | | Deposit date: | 2018-02-26 | | Release date: | 2018-08-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
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7FF9
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7FF8
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7FF0
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6CJQ
 | | Structure of the SthK cyclic nucleotide-gated potassium channel | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel | | Authors: | Nimigean, C.M, Rheinberger, J. | | Deposit date: | 2018-02-26 | | Release date: | 2018-08-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
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7FEW
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5H3O
 | | Structure of a eukaryotic cyclic nucleotide-gated channel | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION | | Authors: | Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. | | Deposit date: | 2016-10-26 | | Release date: | 2017-01-25 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of a eukaryotic cyclic-nucleotide-gated channel.
Nature, 542, 2017
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7ETS
 | | Crystal structure of crp protein from Gardnerella Vaginalis | | Descriptor: | Crp/Fnr family transcriptional regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Dong, H.J, Wang, S, Zhang, J.M, Gu, L. | | Deposit date: | 2021-05-13 | | Release date: | 2022-04-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Crystal structure of crp protein from Gardnerella Vaginalis
To Be Published
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6DT4
 | | 1.8 Angstrom Resolution Crystal Structure of cAMP-Regulatory Protein from Yersinia pestis in Complex with cAMP | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CHLORIDE ION, Cyclic AMP receptor protein | | Authors: | Minasov, G, Shuvalova, L, Kiryukhina, O, Ritzert, J.T.H, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2018-06-15 | | Release date: | 2018-06-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis during Planktonic Growth and Growth in Biofilms.
Mbio, 10, 2019
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4EV0
 | | Crystal Structure of Thermus thermophilus Catabolite Activator Protein | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | | Authors: | Hudson, B.P, Turo, K, Birktoft, J.J, Lawson, C.L. | | Deposit date: | 2012-04-25 | | Release date: | 2012-06-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Crystal Structure of T. thermophilius Catabolite Activator Protein
To be Published
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