3IA2
 
 | | Pseudomonas fluorescens esterase complexed to the R-enantiomer of a sulfonate transition state analog | | Descriptor: | (2R)-butane-2-sulfonate, Arylesterase, GLYCEROL, ... | | Authors: | Schrag, J.D, Kazlauskas, R.J, Jiang, Y, Morley, K. | | Deposit date: | 2009-07-13 | | Release date: | 2010-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Different active-site loop orientation in serine hydrolases versus acyltransferases.
Chembiochem, 12, 2011
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6JRC
 | | ZHD complex with hydrolyzed alpha-ZOL | | Descriptor: | 2-[(~{E},6~{R},10~{S})-6,10-bis(oxidanyl)undec-1-enyl]-4,6-bis(oxidanyl)benzoic acid, GLYCEROL, POTASSIUM ION, ... | | Authors: | Hu, X.J. | | Deposit date: | 2019-04-03 | | Release date: | 2020-04-08 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of ZHD complex
To Be Published
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6JRD
 | | ZHD complex with hydrolyzed beta-ZOL | | Descriptor: | 2-[(~{E},6~{S},10~{S})-6,10-bis(oxidanyl)undec-1-enyl]-4,6-bis(oxidanyl)benzoic acid, GLYCEROL, POTASSIUM ION, ... | | Authors: | Hu, X.J. | | Deposit date: | 2019-04-03 | | Release date: | 2020-04-08 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of ZHD complex
To Be Published
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6JR2
 | | ZHD/H242A complex with aZOL | | Descriptor: | (3S,7R,11E)-7,14,16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one, GLYCEROL, POTASSIUM ION, ... | | Authors: | Hu, X.J. | | Deposit date: | 2019-04-02 | | Release date: | 2020-04-08 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of ZHD complex
To Be Published
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3OOS
 | | The structure of an alpha/beta fold family hydrolase from Bacillus anthracis str. Sterne | | Descriptor: | Alpha/beta hydrolase family protein, GLYCEROL, SULFATE ION, ... | | Authors: | Fan, Y, Tan, K, Bigelow, L, Hamilton, J, Li, H, Zhou, Y, Clancy, S, Buck, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2010-08-31 | | Release date: | 2010-11-10 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The structure of an alpha/beta fold family hydrolase from Bacillus anthracis str. Sterne
To be Published
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2D0D
 | | Crystal Structure of a Meta-cleavage Product Hydrolase (CumD) A129V Mutant | | Descriptor: | 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase, CHLORIDE ION, PHOSPHATE ION | | Authors: | Jun, S.Y, Fushinobu, S, Nojiri, H, Omori, T, Shoun, H, Wakagi, T. | | Deposit date: | 2005-08-01 | | Release date: | 2006-06-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Improving the catalytic efficiency of a meta-cleavage product hydrolase (CumD) from Pseudomonas fluorescens IP01
Biochim.Biophys.Acta, 1764, 2006
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5Z7W
 | | Crystal structure of Striga hermonthica HTL1 (ShHTL1) | | Descriptor: | GLYCEROL, Hyposensitive to light 1, MAGNESIUM ION, ... | | Authors: | Xu, Y, Miyakawa, T, Nakamura, A, Tanokura, M. | | Deposit date: | 2018-01-30 | | Release date: | 2018-08-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.657 Å) | | Cite: | Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga.
Nat Commun, 9, 2018
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6NY9
 | | Alpha/beta hydrolase domain-containing protein 10 from mouse | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Mycophenolic acid acyl-glucuronide esterase, mitochondrial, ... | | Authors: | Cao, Y, Rice, P.A, Dickinson, B.C. | | Deposit date: | 2019-02-11 | | Release date: | 2020-01-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5.
Nat.Chem.Biol., 15, 2019
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4BRZ
 | | Haloalkane dehalogenase | | Descriptor: | CHLORIDE ION, HALOALKANE DEHALOGENASE | | Authors: | Novak, H.R, Sayer, C, Isupov, M, Gotz, D, Spragg, A.M, Littlechild, J.A. | | Deposit date: | 2013-06-06 | | Release date: | 2014-05-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Biochemical and Structural Characterisation of a Haloalkane Dehalogenase from a Marine Rhodobacteraceae.
FEBS Lett., 588, 2014
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4Y7D
 | | Alpha/beta hydrolase fold protein from Nakamurella multipartita | | Descriptor: | Alpha/beta hydrolase fold protein, CHLORIDE ION, SODIUM ION | | Authors: | Cuff, M.E, OSIPIUK, J, Holowicki, J, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2015-02-14 | | Release date: | 2015-02-25 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Alpha/beta hydrolase fold protein from Nakamurella multipartita.
to be published
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3QIT
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2RI6
 | | Crystal Structure of S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400 | | Descriptor: | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, MALONATE ION, SODIUM ION | | Authors: | Bhowmik, S, Bolin, J.T. | | Deposit date: | 2007-10-10 | | Release date: | 2007-11-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad.
J.Biol.Chem., 282, 2007
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7ZBD
 | | HaloTag with TRaQ-G ligand | | Descriptor: | (10R)-7-azanyl-N-[2-[2-(6-chloranylhexoxy)ethoxy]ethyl]-2'-cyano-5,5-dimethyl-3-(methylamino)-1'-oxidanylidene-spiro[benzo[b][1]benzosiline-10,3'-isoindole]-5'-carboxamide, CHLORIDE ION, GLYCEROL, ... | | Authors: | Emmert, S, Rivera-Fuentes, P, Pojer, F, Lau, K. | | Deposit date: | 2022-03-23 | | Release date: | 2023-02-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | A locally activatable sensor for robust quantification of organellar glutathione.
Nat.Chem., 15, 2023
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4WCV
 | | Haloalkane dehalogenase DhaA mutant from Rhodococcus rhodochrous (T148L+G171Q+A172V+C176G) | | Descriptor: | ACETATE ION, CHLORIDE ION, Haloalkane dehalogenase, ... | | Authors: | Holubeva, T, Prudnikova, T, Kuta-Smatanova, I, Rezacova, P. | | Deposit date: | 2014-09-05 | | Release date: | 2014-10-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Balancing the stability-activity trade-off by fine-tuning dehalogenase access tunnels
Chemcatchem, 2015
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4I3F
 | | Crystal structure of serine hydrolase CCSP0084 from the polyaromatic hydrocarbon (PAH)-degrading bacterium Cycloclasticus zankles | | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | | Authors: | Stogios, P.J, Xu, X, Dong, A, Cui, H, Alcaide, M, Tornes, J, Gertler, C, Yakimov, M.M, Golyshin, P.N, Ferrer, M, Savchenko, A. | | Deposit date: | 2012-11-26 | | Release date: | 2013-06-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Single residues dictate the co-evolution of dual esterases: MCP hydrolases from the alpha / beta hydrolase family.
Biochem.J., 454, 2013
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5W8P
 | | Homoserine transacetylase MetX from Mycobacterium abscessus | | Descriptor: | GLYCEROL, Homoserine O-acetyltransferase, PHOSPHATE ION, ... | | Authors: | Rodriguez, E.S, Reed, R.W, Korotkov, K.V. | | Deposit date: | 2017-06-22 | | Release date: | 2017-07-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site.
Sci Rep, 9, 2019
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6QHY
 | | Time resolved structural analysis of the full turnover of an enzyme - 100 ms | | Descriptor: | Fluoroacetate dehalogenase, fluoroacetic acid | | Authors: | Schulz, E.C, Mehrabi, P, Pai, E.F, Miller, D. | | Deposit date: | 2019-01-17 | | Release date: | 2019-09-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Time-resolved crystallography reveals allosteric communication aligned with molecular breathing.
Science, 365, 2019
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6XT8
 | | Crystal structure of haloalkane dehalogenase variant DhaA115 domain-swapped dimer type-2 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | Authors: | Markova, K, Damborsky, J, Marek, M. | | Deposit date: | 2020-01-15 | | Release date: | 2021-01-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers
Acs Catalysis, 11, 2021
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1UK7
 | | Crystal structure of a meta-cleavage product hydrolase (CumD) complexed with n-butyrate | | Descriptor: | 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase, butanoic acid | | Authors: | Fushinobu, S, Jun, S.-Y, Hidaka, M, Nojiri, H, Yamane, H, Shoun, H, Omori, T, Wakagi, T. | | Deposit date: | 2003-08-19 | | Release date: | 2004-09-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A Series of Crystal Structures of a meta-Cleavage Product Hydrolase from Pseudomonas fluorescens IP01 (CumD) Complexed with Various Cleavage Products
BIOSCI.BIOTECHNOL.BIOCHEM., 69, 2005
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1UKA
 | | Crystal structure of a meta-cleavage product hydrolase (CumD) complexed with (S)-2-methylbutyrate | | Descriptor: | 2-METHYLBUTANOIC ACID, 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase | | Authors: | Fushinobu, S, Jun, S.-Y, Hidaka, M, Nojiri, H, Yamane, H, Shoun, H, Omori, T, Wakagi, T. | | Deposit date: | 2003-08-19 | | Release date: | 2004-09-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A Series of Crystal Structures of a meta-Cleavage Product Hydrolase from Pseudomonas fluorescens IP01 (CumD) Complexed with Various Cleavage Products
BIOSCI.BIOTECHNOL.BIOCHEM., 69, 2005
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1QGE
 | | NEW CRYSTAL FORM OF PSEUDOMONAS GLUMAE (FORMERLY CHROMOBACTERIUM VISCOSUM ATCC 6918) LIPASE | | Descriptor: | CALCIUM ION, PROTEIN (TRIACYLGLYCEROL HYDROLASE) | | Authors: | Lang, D.A, Stadler, P, Kovacs, A, Paltauf, F, Dijkstra, B.W. | | Deposit date: | 1999-04-27 | | Release date: | 1999-05-06 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and Kinetic Investigations of Enantiomeric Binding Mode of Subclass I Lipases from the Family of Pseudomonadaceae
To be Published
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4INZ
 | | The crystal structure of M145A mutant of an epoxide hydrolase from Bacillus megaterium | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Soluble epoxide hydrolase | | Authors: | Kong, X.D, Zhou, J.H, Xu, J.H. | | Deposit date: | 2013-01-07 | | Release date: | 2014-02-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates.
Proc.Natl.Acad.Sci.USA, 111, 2014
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6T6Z
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3VVM
 | | Crystal structure of G52A-P55G mutant of L-serine-O-acetyltransferase found in D-cycloserine biosynthetic pathway | | Descriptor: | Homoserine O-acetyltransferase | | Authors: | Oda, K, Matoba, Y, Kumagai, T, Noda, M, Sugiyama, M. | | Deposit date: | 2012-07-26 | | Release date: | 2013-03-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystallographic study to determine the substrate specificity of an L-serine-acetylating enzyme found in the D-cycloserine biosynthetic pathway
J.Bacteriol., 195, 2013
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3WI7
 | | Crystal Structure of the Novel Haloalkane Dehalogenase DatA from Agrobacterium tumefaciens C58 | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Haloalkane dehalogenase | | Authors: | Guan, L.J, Yabuki, H, Okai, M, Ohtsuka, J, Tanokura, M. | | Deposit date: | 2013-09-06 | | Release date: | 2014-07-23 | | Last modified: | 2022-08-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the novel haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58 reveals a special halide-stabilizing pair and enantioselectivity mechanism.
Appl.Microbiol.Biotechnol., 98, 2014
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