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8WR5
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BU of 8wr5 by Molmil
The Crystal Structure of Mms2 from Biortus
Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S.
Deposit date:2023-10-13
Release date:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Mms2 from Biortus.
To Be Published
7ZJ3
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BU of 7zj3 by Molmil
Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate
Descriptor: Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ...
Authors:Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K.
Deposit date:2022-04-08
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Nat Commun, 13, 2022
1C4Z
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BU of 1c4z by Molmil
STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY
Descriptor: UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A
Authors:Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P.
Deposit date:1999-10-14
Release date:1999-11-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science, 286, 1999
5ZBU
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BU of 5zbu by Molmil
Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub
Descriptor: E3 ubiquitin-protein ligase RNF13, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Datta, A.B, Sarkar, S.
Deposit date:2018-02-12
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub
To Be Published
5YWR
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BU of 5ywr by Molmil
Crystal Structure of RING E3 ligase ZNRF1 in complex with Ube2N (Ubc13)
Descriptor: E3 ubiquitin-protein ligase ZNRF1, FORMIC ACID, TRIETHYLENE GLYCOL, ...
Authors:Behera, A.P, Naskar, P, Datta, A.B.
Deposit date:2017-11-30
Release date:2018-06-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.
Biochem. J., 475, 2018
1FXT
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BU of 1fxt by Molmil
STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX
Descriptor: UBIQUITIN, UBIQUITIN-CONJUGATING ENZYME E2-24 KDA
Authors:Hamilton, K.S, Shaw, G.S, Williams, R.S, Huzil, J.T, McKenna, S, Ptak, C, Glover, M, Ellison, M.J.
Deposit date:2000-09-26
Release date:2001-10-10
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail.
Structure, 9, 2001
6W7Z
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BU of 6w7z by Molmil
RNF12 RING domain in complex with Ube2d2
Descriptor: E3 ubiquitin-protein ligase RLIM, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Middleton, A.J, Day, C.L.
Deposit date:2020-03-19
Release date:2020-05-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains.
J.Mol.Biol., 432, 2020
6W9A
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BU of 6w9a by Molmil
RNF12 RING domain in complex with Ube2e2
Descriptor: E3 ubiquitin-protein ligase RLIM, GLYCEROL, Ubiquitin-conjugating enzyme E2 E2, ...
Authors:Middleton, A.J, Day, C.L.
Deposit date:2020-03-22
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains.
J.Mol.Biol., 432, 2020
4W5V
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BU of 4w5v by Molmil
Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd)
Descriptor: FORMIC ACID, GLYCEROL, POTASSIUM ION, ...
Authors:Boucher, L.E, Reiter, K.H, Matunis, M.J, Bosch, J.
Deposit date:2014-08-19
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human SUMO complex
To Be Published
4V3L
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BU of 4v3l by Molmil
RNF38-UB-UbcH5B-Ub complex
Descriptor: 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF38, POLYUBIQUITIN-C, ...
Authors:Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3K
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BU of 4v3k by Molmil
RNF38-UbcH5B-UB complex
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
Authors:Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
7OJX
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BU of 7ojx by Molmil
E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis
Descriptor: 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), E3 ubiquitin-protein ligase RNF38, Polyubiquitin-B, ...
Authors:Majorek, K.A, Nakasone, M.A, Huang, D.T.
Deposit date:2021-05-17
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Nat.Chem.Biol., 18, 2022
4WHV
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BU of 4whv by Molmil
E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B
Descriptor: E3 ubiquitin-protein ligase RNF8, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Hodge, C.D, Edwards, R.A, Glover, J.N.M.
Deposit date:2014-09-23
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (8.3 Å)
Cite:RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
J.Biol.Chem., 291, 2016
7P47
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BU of 7p47 by Molmil
Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic
Descriptor: E3 SUMO-protein ligase MMS21, SUMO-conjugating enzyme UBC9, Structural maintenance of chromosomes protein 5, ...
Authors:Lascorz, J, Varejao, N, Reverter, D.
Deposit date:2021-07-09
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.314 Å)
Cite:Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs.
Nat Commun, 12, 2021
5HPT
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BU of 5hpt by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1, Ubv P2.3 and UBCH7
Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP1, Ubiquitin variant P2.3, Ubiquitin-conjugating enzyme E2 L3
Authors:Wu, K.-P, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5IFR
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BU of 5ifr by Molmil
Structure of the stable UBE2D3-UbDha conjugate
Descriptor: GLYCEROL, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D3
Authors:Pruneda, J.N, Mulder, M.P.C, Witting, K, Ovaa, H, Komander, D.
Deposit date:2016-02-26
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Nat.Chem.Biol., 12, 2016
7R71
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BU of 7r71 by Molmil
Crystal Structure of the UbArk2C-UbcH5b~Ub complex
Descriptor: Ubiquitin, Ubiquitin,E3 ubiquitin-protein ligase RNF165, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L.
Deposit date:2021-06-24
Release date:2022-03-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
Nat Commun, 13, 2022
5JNE
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BU of 5jne by Molmil
E2-SUMO-Siz1 E3-SUMO-PCNA complex
Descriptor: E3 SUMO-protein ligase SIZ1,Ubiquitin-like protein SMT3, GLYCEROL, Proliferating cell nuclear antigen, ...
Authors:Lima, C.D, Streich Jr, F.C.
Deposit date:2016-04-29
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Capturing a substrate in an activated RING E3/E2-SUMO complex.
Nature, 536, 2016
4Q5E
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BU of 4q5e by Molmil
Shigella Effector Kinase OspG bound to E2-Ub UbcH7-Ub Conjugate
Descriptor: Polyubiquitin, Protein kinase OspG, Ubiquitin-conjugating enzyme E2 L3
Authors:Cygler, M, Grishin, A.M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2014-04-16
Release date:2014-07-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.869 Å)
Cite:Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG.
Structure, 22, 2014
4QPL
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BU of 4qpl by Molmil
Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex
Descriptor: 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, ...
Authors:Wang, Z, DaRosa, P.A, Klevit, R.E, Xu, W.
Deposit date:2014-06-23
Release date:2014-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Nature, 517, 2015
6P5B
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BU of 6p5b by Molmil
Crystal Structure of MavC in Complex with Ub-UbE2N
Descriptor: MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N
Authors:Puvar, K, Iyer, S, Negron Teron, K.I, Das, C.
Deposit date:2019-05-30
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination.
Nat Commun, 11, 2020
4R62
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BU of 4r62 by Molmil
Structure of Rad6~Ub
Descriptor: ACETATE ION, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 2
Authors:Kumar, P, Wolberger, C.
Deposit date:2014-08-22
Release date:2015-09-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.
Nucleic Acids Res., 43, 2015
4TKP
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BU of 4tkp by Molmil
Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor
Descriptor: SULFATE ION, Tripartite motif-containing protein 5, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Johnson, R, Taylor, A.B, Hart, P.J, Ivanov, D.N.
Deposit date:2014-05-27
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:RING Dimerization Links Higher-Order Assembly of TRIM5 alpha to Synthesis of K63-Linked Polyubiquitin.
Cell Rep, 12, 2015
4S3O
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BU of 4s3o by Molmil
PCGF5-RING1B-UbcH5c complex
Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:Taherbhoy, A.M, Cochran, A.G.
Deposit date:2015-03-23
Release date:2015-07-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
3OJ4
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BU of 3oj4 by Molmil
Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex
Descriptor: Tumor necrosis factor alpha-induced protein 3, Ubiquitin, Ubiquitin-conjugating enzyme E2 D1, ...
Authors:Bosanac, I, Hymowitz, S.G.
Deposit date:2010-08-20
Release date:2010-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling
Mol.Cell, 40, 2010

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