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4RHG
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BU of 4rhg by Molmil
Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide
Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3
Authors:Chen, K.-E, Meng, T.C, Wang, A.H.-J.
Deposit date:2014-10-02
Release date:2015-03-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.581 Å)
Cite:Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4RI4
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BU of 4ri4 by Molmil
Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate
Descriptor: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION
Authors:Chen, K.-E, Meng, T.C, Wang, A.H.-J.
Deposit date:2014-10-05
Release date:2015-03-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.596 Å)
Cite:Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4RI5
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Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium
Authors:Chen, K.-E, Meng, T.C, Wang, A.H.-J.
Deposit date:2014-10-05
Release date:2015-03-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
4S0G
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BU of 4s0g by Molmil
Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide
Descriptor: Peptide from Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3
Authors:Chen, K.-E, Meng, T.C, Wang, A.H.-J.
Deposit date:2014-12-31
Release date:2015-03-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.723 Å)
Cite:Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015
1EEN
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BU of 1een by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G
Descriptor: ACETIC ACID, ALA-ASP-PBF-PTR-LEU-ILE-PRO, MAGNESIUM ION, ...
Authors:Puius, Y.A, Zhao, Y, Almo, S.C, Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1ECV
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BU of 1ecv by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor: 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID, ACETATE ION, PROTEIN-TYROSINE PHOSPHATASE 1B
Authors:Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.H.
Deposit date:2000-01-26
Release date:2000-03-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1EEO
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BU of 1eeo by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2
Descriptor: ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Sarmiento, M, Puius, Y.A, Vetter, S.W, Lawrence, D.S, Almo, S.C, Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1FPR
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BU of 1fpr by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.
Descriptor: PEPTIDE PY469, PROTEIN-TYROSINE PHOSPHATASE 1C
Authors:Yang, J, Cheng, Z, Niu, Z, Zhao, Z.J, Zhou, G.W.
Deposit date:2000-08-31
Release date:2001-03-07
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 275, 2000
1G7F
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BU of 1g7f by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496
Descriptor: 2-{4-[(2S)-2-[({[(1S)-1-CARBOXY-2-PHENYLETHYL]AMINO}CARBONYL)AMINO]-3-OXO-3-(PENTYLAMINO)PROPYL]PHENOXY}MALONIC ACID, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
Authors:Bleasdale, J.E, Ogg, D, Larsen, S.D.
Deposit date:2000-11-10
Release date:2001-06-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1G1H
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BU of 1g1h by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor: BI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G7G
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BU of 1g7g by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326
Descriptor: 2-(CARBOXYMETHOXY)-5-[(2S)-2-({(2S)-2-[(3-CARBOXYPROPANOYL)AMINO] -3-PHENYLPROPANOYL}AMINO)-3-OXO-3-(PENTYLAMINO)PROPYL]BENZOIC ACID, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
Authors:Bleasdale, J.E, Ogg, D, Larsen, S.D.
Deposit date:2000-11-10
Release date:2001-06-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1G1G
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BU of 1g1g by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor: MONO-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE, PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1F
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BU of 1g1f by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE
Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B, TRI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE
Authors:Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1GFY
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BU of 1gfy by Molmil
RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Iversen, L.F.
Deposit date:2000-06-26
Release date:2000-07-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.
J.Biol.Chem., 275, 2000
8EYB
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BU of 8eyb by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with JAK2 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein kinase JAK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-26
Release date:2023-07-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXN
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BU of 8exn by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Non-receptor tyrosine-protein kinase TYK2 activation loop peptide, PHOSPHATE ION, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXI
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BU of 8exi by Molmil
Crystal structure of apo PTP1B D181A/Q262A phosphatase domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EYA
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BU of 8eya by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with a JAK2 activation loop phosphopeptide
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-26
Release date:2023-07-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXJ
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BU of 8exj by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK1 activation loop peptide, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8F88
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BU of 8f88 by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with monophosphorylated JAK2 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein kinase JAK2, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-11-21
Release date:2023-07-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXK
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BU of 8exk by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain with JAK2 activation loop phosphopeptide
Descriptor: PHOSPHATE ION, Tyrosine-protein kinase JAK2 activation loop peptide, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXM
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BU of 8exm by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain with a JAK3 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK3 activation loop peptide, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EYC
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BU of 8eyc by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide
Descriptor: Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-26
Release date:2023-08-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8G65
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BU of 8g65 by Molmil
Wildtype PTP1b in complex with DES4799
Descriptor: 4-(3,5-dimethyl-1H-pyrazol-1-yl)aniline, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Greisman, J.B, Willmore, L, Yeh, C.Y, Giordanetto, F, Shahamadtar, S, Nisonoff, H, Maragakis, P, Shaw, D.E.
Deposit date:2023-02-14
Release date:2023-04-26
Last modified:2023-05-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography.
J.Chem.Inf.Model., 63, 2023
8G68
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Wildtype PTP1b in complex with DES5742
Descriptor: 4-(3-ethyl-5-methyl-1H-pyrazol-1-yl)aniline, Tyrosine-protein phosphatase non-receptor type 1
Authors:Greisman, J.B, Willmore, L, Yeh, C.Y, Giordanetto, F, Shahamadtar, S, Nisonoff, H, Maragakis, P, Shaw, D.E.
Deposit date:2023-02-14
Release date:2023-04-26
Last modified:2023-05-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography.
J.Chem.Inf.Model., 63, 2023

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