PDB: 591 resultsInfo pagesStatus searchChemie searchBIRD

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3WA4	Grb2 SH2 domain/CD28-derived peptide complex Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... Authors: Higo, K, Oda, M, Ito, N. Deposit date: 2013-04-23 Release date: 2014-02-26 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
5TNW	Phospholipase C gamma-1 C-terminal SH2 domain Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-14 Release date: 2017-04-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TO4	Phospholipase C gamma-1 C-terminal SH2 domain, spacegroup P212121 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-16 Release date: 2017-04-19 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-07 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide E683V variant, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-08 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
5TQ1	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Insulin receptor Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-21 Release date: 2017-04-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.485 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5U06	Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic Descriptor: Growth factor receptor-bound protein 7, POTASSIUM ION, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST Authors: Watson, G.M, Wilce, J.A. Deposit date: 2016-11-22 Release date: 2017-11-15 Last modified: 2020-01-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
5TQS	Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Receptor protein-tyrosine kinase Authors: Wuttke, D.S, McKercher, M.A. Deposit date: 2016-10-24 Release date: 2017-04-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.876 Å) Cite: Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein. Biochemistry, 56, 2017
5TYI	Grb7 SH2 with bicyclic peptide containing pY mimetic Descriptor: Growth factor receptor-bound protein 7, Peptide inhibitor Authors: Watson, G.M, Wilce, M.C.J, Wilce, J.A. Deposit date: 2016-11-20 Release date: 2017-11-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV Descriptor: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
5U1Q	Grb7-SH2 with bicyclic peptide inhibitor Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST Authors: Watson, G.M, Wilce, M.C.J, Wilce, J.A. Deposit date: 2016-11-28 Release date: 2017-11-15 Last modified: 2020-01-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60, 2017
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
5VKO	SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493 Descriptor: DNA-directed RNA polymerase II subunit RPB1, ISOPROPYL ALCOHOL, Transcription elongation factor SPT6 Authors: Sdano, M.A, Whitby, F.G, Hill, C.P. Deposit date: 2017-04-21 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
5VKL	SPT6 tSH2-RPB1 1476-1500 pS1493 Descriptor: DNA-directed RNA polymerase II subunit RPB1, Transcription elongation factor SPT6 Authors: Sdano, M.A, Whitby, F.G, Hill, C.P. Deposit date: 2017-04-21 Release date: 2017-10-25 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.198 Å) Cite: A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
5W3R	SH2B1 SH2 Domain Descriptor: PHENOL, PHOSPHATE ION, SH2B adapter protein 1 Authors: McKercher, M.A, Wuttke, D.S. Deposit date: 2017-06-08 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.386 Å) Cite: Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PQZ	Grb7 SH2 with peptide Descriptor: Growth factor receptor-bound protein 7, cyclic peptide Authors: Wilce, J.A. Deposit date: 2010-11-29 Release date: 2011-07-20 Last modified: 2011-09-21 Method: X-RAY DIFFRACTION (2.413 Å) Cite: Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
5X94	Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex Descriptor: Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11 Authors: Senda, M, Senda, T. Deposit date: 2017-03-05 Release date: 2017-09-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20, 2017
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S9K	Crystal structure of the Itk SH2 domain. Descriptor: CITRIC ACID, Tyrosine-protein kinase ITK/TSK Authors: Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. Deposit date: 2011-06-01 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.354 Å) Cite: Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011

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