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1D3G
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BU of 1d3g by Molmil
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG
Descriptor: 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
Authors:Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J.
Deposit date:1999-09-29
Release date:2000-09-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1D3H
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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Descriptor: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
Authors:Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J.
Deposit date:1999-09-29
Release date:2000-08-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
1DOR
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DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS
Descriptor: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE
Authors:Rowland, P, Larsen, S.
Deposit date:1997-01-14
Release date:1997-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.
Structure, 5, 1997
1JQV
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The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A
Descriptor: ACETIC ACID, Dihydroorotate dehydrogenase A, FLAVIN MONONUCLEOTIDE, ...
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2001-08-09
Release date:2003-09-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JRB
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The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
Descriptor: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2001-08-13
Release date:2003-09-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JUB
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BU of 1jub by Molmil
The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A
Descriptor: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ...
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2001-08-24
Release date:2003-09-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JQX
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The R57A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
Descriptor: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ...
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2001-08-09
Release date:2003-09-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JRC
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The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
Descriptor: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2001-08-13
Release date:2003-09-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JUE
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1.8 A resolution structure of native lactococcus lactis dihydroorotate dehydrogenase A
Descriptor: ACETIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
Deposit date:2001-08-24
Release date:2003-09-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1F76
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ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE
Descriptor: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ...
Authors:Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S.
Deposit date:2000-06-26
Release date:2002-10-16
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases
Structure, 10, 2002
6FMD
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Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold
Descriptor: 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide, ACETATE ION, CHLORIDE ION, ...
Authors:Goyal, P, Jarva, M, Andersson, M, Lolli, M.L, Friemann, R.
Deposit date:2018-01-30
Release date:2018-07-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
J. Med. Chem., 61, 2018
6GK0
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BU of 6gk0 by Molmil
HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR
Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 4-~{tert}-butyl-~{N}-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide, ACETIC ACID, ...
Authors:Hakansson, M, Ladds, M.J.G.W, Walse, B, Lain, S.
Deposit date:2018-05-17
Release date:2019-11-27
Last modified:2021-04-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
J.Biol.Chem., 295, 2020
6GJG
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BU of 6gjg by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase DHODH in complex with 3,6-dimethyl-N-(4-(trifluoromethyl)phenyl)-(1,2)oxazolo(5,4-d)pyrimidin-4-amine
Descriptor: 3,6-dimethyl-~{N}-[4-(trifluoromethyl)phenyl]-[1,2]oxazolo[5,4-d]pyrimidin-4-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Rowland, P.
Deposit date:2018-05-16
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity.
ACS Omega, 3, 2018
6I4B
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BU of 6i4b by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with 3-Hydroxy-1-methyl-5-((3-(trifluoromethyl)phenoxy)methyl)-1H-pyrazole-4-carboxylic acid
Descriptor: 1-methyl-3-oxidanyl-5-[[3-(trifluoromethyl)phenoxy]methyl]pyrazole-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Goyal, P, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S.
Deposit date:2018-11-09
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.
Eur J Med Chem, 163, 2018
6I55
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BU of 6i55 by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide
Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide, ...
Authors:Goyal, P, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S.
Deposit date:2018-11-12
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.
Eur J Med Chem, 163, 2018
6IDJ
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BU of 6idj by Molmil
Crystal structure of human DHODH in complex with ferulenol
Descriptor: 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S.
Deposit date:2018-09-10
Release date:2019-09-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
6J3B
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BU of 6j3b by Molmil
Crystal structure of human DHODH in complex with inhibitor 1289
Descriptor: (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, ACETATE ION, CHLORIDE ION, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-01-04
Release date:2019-08-21
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019
6J3C
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BU of 6j3c by Molmil
Crystal structure of human DHODH in complex with inhibitor 1291
Descriptor: (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-01-04
Release date:2019-08-21
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019
6JMD
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BU of 6jmd by Molmil
Crystal structure of human DHODH in complex with inhibitor 1223
Descriptor: 3-[3,5-bis(fluoranyl)-4-[3-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.781 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6JME
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BU of 6jme by Molmil
Crystal structure of human DHODH in complex with inhibitor 0946
Descriptor: 3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
3G0U
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BU of 3g0u by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4
Descriptor: (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Davis, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P.
Deposit date:2009-01-28
Release date:2009-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3G0X
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Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5
Descriptor: (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Davies, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P.
Deposit date:2009-01-29
Release date:2009-06-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3GYE
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BU of 3gye by Molmil
Didydroorotate dehydrogenase from Leishmania major
Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
Authors:Cordeiro, A.T, Feliciano, P.R, Nonato, M.C.
Deposit date:2009-04-03
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Leishmania major Dihydroorotate dehydrogenase
To be Published
5XFV
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BU of 5xfv by Molmil
Crystal structures of FMN-bound form of dihydroorotate dehydrogenase from Trypanosoma brucei
Descriptor: Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, MALONATE ION
Authors:Kubota, T, Tani, O, Yamaguchi, T, Namatame, I, Sakashita, H, Furukawa, K, Yamasaki, K.
Deposit date:2017-04-11
Release date:2018-04-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase fromTrypanosoma brucei.
FEBS Open Bio, 8, 2018
3GZ3
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Leishmania major Dihydroorotate Dehydrogenase in complex with orotate
Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
Authors:Cordeiro, A.T, Feliciano, P.R, Nonato, M.C.
Deposit date:2009-04-06
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Leismania major dihydroorotate in complex with orotate
To be Published

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