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3Q9B	Crystal Structure of APAH complexed with M344 Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Acetylpolyamine amidohydrolase, DIMETHYL SULFOXIDE, ... Authors: Lombardi, P.M, Christianson, D.W. Deposit date: 2011-01-07 Release date: 2011-03-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases . Biochemistry, 50, 2011
3EZP	Crystal Structure Analysis of human HDAC8 D101N variant Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, BETA-MERCAPTOETHANOL, Histone deacetylase 8, ... Authors: Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. Deposit date: 2008-10-23 Release date: 2008-12-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
3Q9C	Crystal Structure of H159A APAH complexed with N8-acetylspermidine Descriptor: Acetylpolyamine amidohydrolase, N-{4-[(3-aminopropyl)amino]butyl}acetamide, POTASSIUM ION, ... Authors: Lombardi, P.M, Christianson, D.W. Deposit date: 2011-01-07 Release date: 2011-03-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases . Biochemistry, 50, 2011
3EW8	Crystal Structure Analysis of human HDAC8 D101L variant Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, BETA-MERCAPTOETHANOL, GLYCEROL, ... Authors: Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. Deposit date: 2008-10-14 Release date: 2008-12-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
3F0R	Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form Descriptor: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... Authors: Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. Deposit date: 2008-10-25 Release date: 2008-12-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
4QA5	Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QA6	Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.053 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QA2	Crystal structure of I243N HDAC8 in complex with SAHA Descriptor: GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.377 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
3RQD	Ideal Thiolate-Zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8 Descriptor: Histone deacetylase 8, Largazole, POTASSIUM ION, ... Authors: Cole, K.E, Dowling, D.P, Christianson, D.W. Deposit date: 2011-04-28 Release date: 2011-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.143 Å) Cite: Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J.Am.Chem.Soc., 133, 2011
4QA1	Crystal structure of A188T HDAC8 in complex with M344 Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QA4	Crystal structure of H334R HDAC8 in complex with M344 Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QA0	Crystal structure of C153F HDAC8 in complex with SAHA Descriptor: GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.242 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QA3	Crystal structure of T311M HDAC8 in complex with Trichostatin A (TSA) Descriptor: GLYCEROL, Histone deacetylase 8, POTASSIUM ION, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.876 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QA7	Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... Authors: Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. Deposit date: 2014-05-02 Release date: 2014-08-06 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
3SFH	Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor Descriptor: (2R)-2-amino-3-(2,4-dichlorophenyl)-1-(1,3-dihydro-2H-isoindol-2-yl)propan-1-one, ACETATE ION, Histone deacetylase 8, ... Authors: Stams, T, Vash, B. Deposit date: 2011-06-13 Release date: 2011-07-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg.Med.Chem., 19, 2011
5ZOO	Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP1 fragment Descriptor: Histone deacetylase 4, POTASSIUM ION, SMRT corepressor SP1 fragment, ... Authors: Park, S.Y, Hwang, H.J, Kim, J.S. Deposit date: 2018-04-13 Release date: 2018-11-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4. Nucleic Acids Res., 46, 2018
5ZOP	Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP2 fragment Descriptor: Histone deacetylase 4, POTASSIUM ION, SMRT corepressor SP2 fragment, ... Authors: Park, S.Y, Hwang, H.J, Kim, J.S. Deposit date: 2018-04-13 Release date: 2018-10-10 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.698 Å) Cite: Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4. Nucleic Acids Res., 46, 2018
5ZMP	The structure of a lysine deacylase Descriptor: ZINC ION, lysine deacylase Authors: Ge, F. Deposit date: 2018-04-05 Release date: 2019-02-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.19 Å) Cite: The structure of a lysine deacylase To Be Published
7SGG	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with SAHA Descriptor: DI(HYDROXYETHYL)ETHER, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGK	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-728 Descriptor: N-(2-{[4-(hydroxyamino)-4-oxobutyl](methyl)amino}ethyl)benzamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGI	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14 Descriptor: 5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-711 Descriptor: 1,2-ETHANEDIOL, 4-[(3-anilino-3-oxopropyl)(methyl)amino]-N-hydroxybutanamide, DI(HYDROXYETHYL)ETHER, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2021-10-05 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7U6B	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Indolethyl Piperidine-4-acrylhydroxamic Acid Inhibitor Descriptor: (2E)-N-hydroxy-3-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}prop-2-enamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-03-03 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022
7U69	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Phenethyl Piperidine-4-acrylhydroxamic Acid Inhibitor Descriptor: (2E)-N-hydroxy-3-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-03-03 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022
7U3M	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with N-methylpiperazine Benzhydroxamic Acid Descriptor: N-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]benzamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2022-02-27 Release date: 2022-04-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234, 2022

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