PDB: 291 resultsInfo pagesStatus searchChemie searchBIRD

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7QHS	S. cerevisiae CMGE nucleating origin DNA melting Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... Authors: Lewis, J.S, Sousa, J.S, Costa, A. Deposit date: 2021-12-14 Release date: 2022-06-15 Last modified: 2022-07-06 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature, 606, 2022
7RSU	TNA polymerase, n+2 product Descriptor: DNA polymerase, Primer, Template Authors: Maola, V, Chaput, J, Chim, N. Deposit date: 2021-08-11 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities. J.Am.Chem.Soc., 143, 2021
6TNZ	Human polymerase delta-FEN1-PCNA toolbelt Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... Authors: Lancey, C, Hamdan, S.M, De Biasio, A. Deposit date: 2019-12-10 Release date: 2019-12-18 Last modified: 2020-03-11 Method: ELECTRON MICROSCOPY (4.05 Å) Cite: Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
6TNY	Processive human polymerase delta holoenzyme Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... Authors: Lancey, C, Hamdan, S.M, De Biasio, A. Deposit date: 2019-12-10 Release date: 2019-12-18 Last modified: 2020-03-11 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
8B9B	S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9A	S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9C	S. cerevisiae pol alpha - replisome complex Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B9D	Human replisome bound by Pol Alpha Descriptor: Cell division control protein 45 homolog, Claspin, DNA Molecule, ... Authors: Jones, M.L, Yeeles, J.T.P. Deposit date: 2022-10-05 Release date: 2023-08-09 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
8B67	The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-26 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B79	The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.65 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B7E	The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site Descriptor: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B6K	The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active site Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-27 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B77	The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-29 Release date: 2023-10-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8B76	The crystal structure of M644G variant of DNA Pol Epsilon containing dTTP in the polymerase active site Descriptor: ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... Authors: Parkash, V, Johansson, E. Deposit date: 2022-09-28 Release date: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8D0B	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. Deposit date: 2022-05-26 Release date: 2022-06-22 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
8D0K	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. Deposit date: 2022-05-26 Release date: 2022-06-22 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4.27 Å) Cite: Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
4M3W	RB69 DNA polymerase ternary complex with dT/dG at position n-4 of primer/template duplex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... Authors: Xia, S, Konigsberg, W.H. Deposit date: 2013-08-06 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci., 23, 2014
8D96	Human DNA polymerase alpha/primase elongation complex I bound to primer/template Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... Authors: He, Q, Baranovskiy, A, Lim, C, Tahirov, T. Deposit date: 2022-06-09 Release date: 2023-04-19 Last modified: 2023-05-31 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
8D9D	Human DNA polymerase-alpha/primase elongation complex II bound to primer/template Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... Authors: He, Q, Baranovskiy, A, Lim, C, Tahirov, T. Deposit date: 2022-06-09 Release date: 2023-04-19 Last modified: 2023-05-31 Method: ELECTRON MICROSCOPY (3.59 Å) Cite: Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
4M3Z	RB69 DNA polymerase ternary complex with dG/dT at position n-2 of primer/tempLate duplex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... Authors: Xia, S, Konigsberg, W.H. Deposit date: 2013-08-06 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci., 23, 2014
4M41	RB69 DNA polymerase ternary complex with dG/dT at position n-3 of primer/tempLate duplex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... Authors: Xia, S, Konigsberg, W.H. Deposit date: 2013-08-06 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci., 23, 2014
4M3X	RB69 DNA polymerase ternary complex with dT/dG at position n-5 of primer/template duplex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... Authors: Xia, S, Konigsberg, W.H. Deposit date: 2013-08-06 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci., 23, 2014
4M42	RB69 DNA polymerase ternary complex with dG/dT at position n-4 of primer/tempLate duplex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... Authors: Xia, S, Konigsberg, W.H. Deposit date: 2013-08-06 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci., 23, 2014
8HDZ	Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in an apo form Descriptor: A22 DNA replication processivity factor, E4 uracil-DNA glycosylase, F8 DNA polymerase Authors: Xu, Y, Wu, Y, Zhang, Y, Fan, R, Yang, Y, Li, D, Yang, B, Zhang, Z, Dong, C. Deposit date: 2022-11-07 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex. Cell Res., 33, 2023
4M3U	RB69 DNA polymerase ternary complex with dT/dG at position n-3 of primer/template duplex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... Authors: Xia, S, Konigsberg, W.H. Deposit date: 2013-08-06 Release date: 2014-02-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci., 23, 2014

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