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4YVD
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BU of 4yvd by Molmil
Crytsal structure of human Pleiotropic Regulator 1 (PRL1)
Descriptor: CHLORIDE ION, Pleiotropic regulator 1, SODIUM ION, ...
Authors:Dong, A, Zeng, H, Xu, C, Tempel, W, Li, Y, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2015-03-19
Release date:2015-04-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
4ZOY
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BU of 4zoy by Molmil
Crystal structure of the Chaetomium thermophilum Sqt1
Descriptor: Sqt1
Authors:Pausch, P, Altegoer, F, Bange, G.
Deposit date:2015-05-07
Release date:2015-07-01
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
Nat Commun, 6, 2015
4ZOV
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BU of 4zov by Molmil
Crystal structure of the Saccharomyces cerevisiae Sqt1
Descriptor: Ribosome assembly protein SQT1
Authors:Pausch, P, Altegoer, F, Bange, G.
Deposit date:2015-05-07
Release date:2015-07-01
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
Nat Commun, 6, 2015
4ZN4
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BU of 4zn4 by Molmil
Crystal structure of Sqt1 from Chaetomium thermophilum solved by MR
Descriptor: GLYCEROL, SULFATE ION, sqt1
Authors:Ahmed, Y.L, Sinning, I.
Deposit date:2015-05-04
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
Nat Commun, 6, 2015
4ZOZ
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Crystal structure of the Chaetomium thermophilum Sqt1 bound to the N-terminus of the ribosomal protein L10
Descriptor: 60S ribosomal protein L10-like protein, Sqt1
Authors:Pausch, P, Altegoer, F, Bange, G.
Deposit date:2015-05-07
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
Nat Commun, 6, 2015
4ZOX
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BU of 4zox by Molmil
Crystal structure of the Saccharomyces cerevisiae Sqt1 bound to the N-terminus of the ribosomal protein L10
Descriptor: 60S ribosomal protein L10, Ribosome assembly protein SQT1
Authors:Pausch, P, Altegoer, F, Bange, G.
Deposit date:2015-05-07
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.
Nat Commun, 6, 2015
5K19
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BU of 5k19 by Molmil
Crystal structure of WD repeat-containing protein 20
Descriptor: GLYCEROL, SULFATE ION, WD repeat-containing protein 20
Authors:Li, H, D'Andrea, A.D, Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
4CY1
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BU of 4cy1 by Molmil
Crystal structure of the KANSL1-WDR5 complex.
Descriptor: GLYCEROL, KAT8 REGULATORY NSL COMPLEX SUBUNIT 1, WD REPEAT-CONTAINING PROTEIN 5
Authors:Dias, J, Brettschneider, J, Cusack, S, Kadlec, J.
Deposit date:2014-04-09
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
4CY2
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BU of 4cy2 by Molmil
Crystal structure of the KANSL1-WDR5-KANSL2 complex.
Descriptor: KAT8 REGULATORY NSL COMPLEX SUBUNIT 1, KAT8 REGULATORY NSL COMPLEX SUBUNIT 2, WD REPEAT-CONTAINING PROTEIN 5
Authors:Dias, J, Brettschneider, J, Cusack, S, Kadlec, J.
Deposit date:2014-04-09
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
4CY5
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BU of 4cy5 by Molmil
Crystal structure of the NSL1-WDS-NSL2 complex.
Descriptor: CG4699, ISOFORM D, DIM GAMMA-TUBULIN 1, ...
Authors:Dias, J, Brettschneider, J, Cusack, S, Kadlec, J.
Deposit date:2014-04-10
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
4CY3
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BU of 4cy3 by Molmil
Crystal structure of the NSL1-WDS complex.
Descriptor: CG4699, ISOFORM D, GLYCEROL, ...
Authors:Dias, J, Brettschneider, J, Cusack, S, Kadlec, J.
Deposit date:2014-04-10
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
4D6V
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BU of 4d6v by Molmil
Crystal structure of signal transducing protein
Descriptor: G PROTEIN BETA SUBUNIT GIB2
Authors:Ero, R, Dimitrova, V.T, Chen, Y, Bu, W, Feng, S, Liu, T, Wang, P, Xue, C, Tan, S.M, Gao, Y.G.
Deposit date:2014-11-17
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Gib2, a Signal-Transducing Protein Scaffold Associated with Ribosomes in Cryptococcus Neoformans.
Sci.Rep., 5, 2015
5K0M
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BU of 5k0m by Molmil
Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED
Descriptor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED
Authors:Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C.
Deposit date:2016-05-17
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat. Chem. Biol., 13, 2017
5AMS
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BU of 5ams by Molmil
Crystal structure of Sqt1
Descriptor: RIBOSOME ASSEMBLY PROTEIN SQT1
Authors:Frenois, F, Legrand, P, Fribourg, S.
Deposit date:2015-08-31
Release date:2016-01-13
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Sqt1P is an Eight-Bladed Wd40 Protein
Acta Crystallogr.,Sect.F, 72, 2016
4ES0
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BU of 4es0 by Molmil
X-ray structure of WDR5-SETd1b Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase SETD1B, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.817 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERZ
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BU of 4erz by Molmil
X-ray structure of WDR5-MLL4 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4EWR
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BU of 4ewr by Molmil
X-ray structure of WDR5-SETd1a Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-27
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERY
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BU of 4ery by Molmil
X-ray structure of WDR5-MLL3 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-21
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ESG
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BU of 4esg by Molmil
X-ray structure of WDR5-MLL1 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-23
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERQ
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BU of 4erq by Molmil
X-ray structure of WDR5-MLL2 Win motif peptide binary complex
Descriptor: Histone-lysine N-methyltransferase MLL2, WD repeat-containing protein 5
Authors:Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
Deposit date:2012-04-20
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4FHL
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BU of 4fhl by Molmil
Nucleoporin Nup37 from Schizosaccharomyces pombe
Descriptor: 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
Authors:Bilokapic, S, Schwartz, T.U.
Deposit date:2012-06-06
Release date:2012-09-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GM8
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BU of 4gm8 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-102
Descriptor: MM-102, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GM9
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BU of 4gm9 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-401
Descriptor: MM-401, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
4GM3
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BU of 4gm3 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-101
Descriptor: MM-101, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.393 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GMB
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BU of 4gmb by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-402
Descriptor: MM-402, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J.Med.Chem., 60, 2017

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PDB entries from 2024-03-13

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