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8PSK
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BU of 8psk by Molmil
Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASx sample)
Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PSM
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BU of 8psm by Molmil
Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the malonyl/palmitoyl transferase domain (FASx sample)
Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ...
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PSJ
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BU of 8psj by Molmil
Asymmetric unit of the yeast fatty acid synthase in the semi rotated state with ACP at the acetyl transferase domain (FASx sample)
Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ...
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PS8
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BU of 8ps8 by Molmil
Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the enoyl reductase domain (FASam sample)
Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-26
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PS2
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BU of 8ps2 by Molmil
Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam sample)
Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ...
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PS9
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BU of 8ps9 by Molmil
Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASam sample)
Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ...
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PSL
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BU of 8psl by Molmil
Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASx sample)
Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8PSF
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BU of 8psf by Molmil
Asymmetric unit of the yeast fatty acid synthase in non-rotated state with ACP at the acetyl transferase domain (FASx sample)
Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ...
Authors:Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A.
Deposit date:2023-07-13
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
8SMS
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BU of 8sms by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide
Authors:Jiang, Z, Chen, A, Chen, J, Sekhon, A, Louie, G.V, Noel, J.P, La Clair, J.J, Burkart, M.D.
Deposit date:2023-04-26
Release date:2023-09-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Masked cerulenin enables a dual-site selective protein crosslink.
Chem Sci, 14, 2023
8EE0
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BU of 8ee0 by Molmil
KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2
Descriptor: 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase
Authors:Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
Deposit date:2022-09-06
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
8EE1
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BU of 8ee1 by Molmil
KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5
Descriptor: 6-deoxyerythronolide B synthase, AA5 antibody heavy chain, AA5 antibody light chain
Authors:Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
Deposit date:2022-09-06
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
8IN9
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BU of 8in9 by Molmil
The structure of the GfsA KSQ-AT didomain in complex with the GfsA ACP domain
Descriptor: N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, Polyketide synthase
Authors:Chisuga, T, Murakami, S, Miyanaga, A, Kudo, F, Eguchi, T.
Deposit date:2023-03-09
Release date:2023-05-31
Last modified:2023-06-28
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-Based Analysis of Transient Interactions between Ketosynthase-like Decarboxylase and Acyl Carrier Protein in a Loading Module of Modular Polyketide Synthase.
Acs Chem.Biol., 18, 2023
8CJH
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BU of 8cjh by Molmil
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin
Descriptor: Colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbK
Authors:Bonhomme, S, Dessen, A, Macheboeuf, P.
Deposit date:2023-02-13
Release date:2023-04-26
Last modified:2023-06-14
Method:X-RAY DIFFRACTION (2.982 Å)
Cite:Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin.
Structure, 31, 2023
8G4U
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BU of 8g4u by Molmil
Final ketosynthase+acyltransferase of the erythromycin modular polyketide synthase
Descriptor: EryAIII
Authors:Keatinge-Clay, A.T.
Deposit date:2023-02-10
Release date:2023-03-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures reveal the framework of cis -acyltransferase modular polyketide synthases.
Biorxiv, 2023
8I4Z
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BU of 8i4z by Molmil
CalA3 with hydrolysis product
Descriptor: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I
Authors:Wang, J, Wang, Z.
Deposit date:2023-01-21
Release date:2023-02-22
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
8I4Y
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BU of 8i4y by Molmil
CalA3 complex structure with amidation product
Descriptor: 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I
Authors:Wang, J, Wang, Z.
Deposit date:2023-01-21
Release date:2023-02-22
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
7WVZ
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BU of 7wvz by Molmil
CalA3_modular PKS_KS-AT-DH-KR
Descriptor: Beta-ketoacyl-acyl-carrier-protein synthase I
Authors:Wang, J, Wang, Z.
Deposit date:2022-02-12
Release date:2023-02-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
7TUI
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BU of 7tui by Molmil
Structure of C. albicans FAS in an inhibited state
Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
Authors:Lou, J.W, Mazhab-Jafari, M.T.
Deposit date:2022-02-02
Release date:2023-02-15
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structure of C. albicans FAS in an inhibited state.
To Be Published
7UK4
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BU of 7uk4 by Molmil
KS-AT di-domain of mycobacterial Pks13 with endogenous KS ligand bound
Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND
Authors:Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M.
Deposit date:2022-03-31
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (1.94 Å)
Cite:Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nat.Struct.Mol.Biol., 30, 2023
8CV1
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BU of 8cv1 by Molmil
ACP1-KS-AT domains of mycobacterial Pks13
Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND
Authors:Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M.
Deposit date:2022-05-17
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nat.Struct.Mol.Biol., 30, 2023
8CUZ
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BU of 8cuz by Molmil
KS-AT domains of mycobacterial Pks13 with inward AT conformation
Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND
Authors:Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M.
Deposit date:2022-05-17
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nat.Struct.Mol.Biol., 30, 2023
8CUY
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BU of 8cuy by Molmil
ACP1-KS-AT domains of mycobacterial Pks13
Descriptor: 4'-PHOSPHOPANTETHEINE, Polyketide synthase PKS13, UNKNOWN LIGAND
Authors:Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M.
Deposit date:2022-05-17
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nat.Struct.Mol.Biol., 30, 2023
8CV0
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BU of 8cv0 by Molmil
KS-AT domains of mycobacterial Pks13 with outward AT conformation
Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND
Authors:Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M.
Deposit date:2022-05-17
Release date:2023-02-15
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nat.Struct.Mol.Biol., 30, 2023
7SZ9
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BU of 7sz9 by Molmil
Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16:1-crypto Acyl Carrier Protein, AcpP
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(2-{[(9Z)-hexadec-9-enoyl]amino}ethyl)-beta-alaninamide, ...
Authors:Mindrebo, J.T, Chen, A, Noel, J.P, Burkart, M.D.
Deposit date:2021-11-26
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states.
Acta Crystallogr D Struct Biol, 78, 2022
7ZMA
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BU of 7zma by Molmil
Ketosynthase domain of module 4 from Brevibacillus Brevis orphan BGC11
Descriptor: Putative polyketide synthase
Authors:Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T.
Deposit date:2022-04-19
Release date:2022-09-21
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The structure of a polyketide synthase bimodule core.
Sci Adv, 8, 2022

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PDB entries from 2024-03-27

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