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6WXM
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X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36
Descriptor: Amyloid-beta protein, HEXANE-1,6-DIOL
Authors:Kreutzer, A.G, Nowick, J.S.
Deposit date:2020-05-11
Release date:2020-07-08
Last modified:2020-08-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Crystallography Reveals Parallel and Antiparallel beta-Sheet Dimers of a beta-Hairpin Derived from A beta16-36that Assemble to Form Different Tetramers.
Acs Chem Neurosci, 11, 2020
6YHF
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BU of 6yhf by Molmil
Solution NMR Structure of APP TMD
Descriptor: Amyloid-beta precursor protein
Authors:Silber, M, Muhle-Goll, C.
Deposit date:2020-03-29
Release date:2020-12-09
Last modified:2020-12-23
Method:SOLUTION NMR
Cite:Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
6YHO
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BU of 6yho by Molmil
Solution NMR Structure of APP G38P mutant TM
Descriptor: Amyloid-beta precursor protein G38P mutant
Authors:Silber, M, Muhle-Goll, C.
Deposit date:2020-03-30
Release date:2020-12-09
Last modified:2020-12-23
Method:SOLUTION NMR
Cite:Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
6YHP
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BU of 6yhp by Molmil
Solution NMR Structure of APP V44M mutant TMD
Descriptor: Amyloid-beta precursor protein V44M mutant
Authors:Silber, M, Muhle-Goll, C.
Deposit date:2020-03-30
Release date:2020-12-09
Last modified:2020-12-23
Method:SOLUTION NMR
Cite:Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
6YHX
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BU of 6yhx by Molmil
Solution NMR Structure of APP I45T mutant TMD
Descriptor: Amyloid-beta precursor protein I45T mutant
Authors:Silber, M, Muhle-Goll, C.
Deposit date:2020-03-31
Release date:2020-12-09
Last modified:2020-12-23
Method:SOLUTION NMR
Cite:Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
6YHI
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BU of 6yhi by Molmil
Solution NMR Structure of APP G38L mutant TMD
Descriptor: Amyloid-beta precursor protein G38L mutant
Authors:Silber, M, Muhle-Goll, C.
Deposit date:2020-03-30
Release date:2020-12-09
Last modified:2020-12-23
Method:SOLUTION NMR
Cite:Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
8AZT
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BU of 8azt by Molmil
Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42
Descriptor: Amyloid-beta precursor protein
Authors:Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S.
Deposit date:2022-09-06
Release date:2022-11-02
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
8AZS
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BU of 8azs by Molmil
Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42
Descriptor: Amyloid-beta precursor protein
Authors:Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S.
Deposit date:2022-09-06
Release date:2022-11-02
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
8B9R
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BU of 8b9r by Molmil
Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
Descriptor: Amyloid-beta A4 protein, COPPER (II) ION
Authors:Abelein, A, Ciofi-Baffoni, S, Morman, C, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H.
Deposit date:2022-10-06
Release date:2023-02-01
Method:SOLUTION NMR
Cite:Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Jacs Au, 2, 2022
8B9Q
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BU of 8b9q by Molmil
Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
Descriptor: Amyloid-beta A4 protein, COPPER (II) ION
Authors:Abelein, A, Ciofi-Baffoni, S, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H.
Deposit date:2022-10-06
Release date:2023-02-08
Method:SOLUTION NMR
Cite:Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Jacs Au, 2, 2022
8BG0
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BU of 8bg0 by Molmil
Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40
Descriptor: Amyloid-beta precursor protein
Authors:Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W.
Deposit date:2022-10-27
Release date:2023-01-18
Last modified:2023-02-22
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
8BFZ
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BU of 8bfz by Molmil
Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42
Descriptor: Amyloid-beta precursor protein
Authors:Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W.
Deposit date:2022-10-27
Release date:2023-01-18
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
8BG9
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BU of 8bg9 by Molmil
Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta
Descriptor: Amyloid-beta protein 40
Authors:Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W.
Deposit date:2022-10-27
Release date:2023-01-18
Last modified:2023-02-22
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Acta Neuropathol, 145, 2023
8BFA
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BU of 8bfa by Molmil
Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure
Descriptor: Amyloid-beta precursor protein
Authors:Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W.
Deposit date:2022-10-24
Release date:2023-05-31
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
8BFB
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BU of 8bfb by Molmil
Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)
Descriptor: Amyloid-beta precursor protein
Authors:Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W.
Deposit date:2022-10-24
Release date:2023-05-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
2LNQ
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BU of 2lnq by Molmil
40-residue D23N beta amyloid fibril
Descriptor: P3(40)
Authors:Qiang, W, Yau, W, Luo, Y, Mattson, M.P, Tycko, R.
Deposit date:2012-01-03
Release date:2012-02-08
Last modified:2023-06-14
Method:SOLID-STATE NMR
Cite:Antiparallel beta-sheet architecture in Iowa-mutant beta-amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LOH
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BU of 2loh by Molmil
Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment
Descriptor: P3(42)
Authors:Nadezhdin, K, Bocharov, E, Bocharova, O, Arseniev, A.
Deposit date:2012-01-24
Release date:2012-05-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment.
Febs Lett., 586, 2012
2LMO
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BU of 2lmo by Molmil
Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Negative Stagger
Descriptor: Beta-amyloid protein 40
Authors:Tycko, R, Petkova, A.
Deposit date:2011-12-08
Release date:2011-12-28
Last modified:2017-05-03
Method:SOLID-STATE NMR
Cite:Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008
2LMQ
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BU of 2lmq by Molmil
Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Negative Stagger
Descriptor: Beta-amyloid protein 40
Authors:Tycko, R, Paravastu, A.
Deposit date:2011-12-09
Release date:2011-12-28
Last modified:2017-05-03
Method:SOLID-STATE NMR
Cite:Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008
2LFM
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BU of 2lfm by Molmil
A partially folded structure of amyloid-beta(1 40) in an aqueous environment
Descriptor: Beta-amyloid protein 40
Authors:Vivekanandan, S, Brender, J.R, Lee, S.Y, Ramamoorthy, A.
Deposit date:2011-07-06
Release date:2011-07-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A partially folded structure of amyloid-beta(1-40) in an aqueous environment.
Biochem.Biophys.Res.Commun., 411, 2011
2MJ1
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BU of 2mj1 by Molmil
NMR structure of the soluble A beta 17-34 peptide
Descriptor: Amyloid beta A4 protein
Authors:Fonar, G, Samson, A.O.
Deposit date:2013-12-23
Release date:2014-11-05
Last modified:2022-08-24
Method:SOLUTION NMR
Cite:NMR structure of the water soluble A beta 17-34 peptide.
Biosci.Rep., 34, 2014
2LZ3
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BU of 2lz3 by Molmil
Solution NMR structure of transmembrane domain of amyloid precursor protein WT
Descriptor: Amyloid beta A4 protein
Authors:Chen, W, Wang, C.
Deposit date:2012-09-23
Release date:2013-10-02
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Familial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.
Nat Commun, 5, 2014
2M4J
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BU of 2m4j by Molmil
40-residue beta-amyloid fibril derived from Alzheimer's disease brain
Descriptor: Amyloid beta A4 protein
Authors:Lu, J, Qiang, W, Meredith, S.C, Yau, W, Schweiters, C.D, Tycko, R.
Deposit date:2013-02-05
Release date:2013-09-25
Last modified:2023-06-14
Method:SOLID-STATE NMR
Cite:Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue.
Cell(Cambridge,Mass.), 154, 2013
2M9R
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BU of 2m9r by Molmil
3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside
Descriptor: (2S,3S)-3-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-6-yl beta-D-glucopyranoside, Amyloid beta A4 protein
Authors:Monti, J, Richard, T.
Deposit date:2013-06-19
Release date:2013-09-11
Method:SOLUTION NMR
Cite:3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside: Implications in Alzheimer's disease.
Biochim.Biophys.Acta, 1830, 2013
2M9S
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BU of 2m9s by Molmil
3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside
Descriptor: (2S,3S)-3-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-6-yl beta-D-glucopyranoside, Amyloid beta A4 protein
Authors:Monti, J, Richard, T.
Deposit date:2013-06-19
Release date:2013-09-11
Method:SOLUTION NMR
Cite:3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside: Implications in Alzheimer's disease.
Biochim.Biophys.Acta, 1830, 2013

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