Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7PUX
DownloadVisualize
BU of 7pux by Molmil
Structure of p97 N-D1(L198W) in complex with Fragment TROLL2
Descriptor: (1S)-2-amino-1-(4-bromophenyl)ethan-1-ol, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bothe, S, Schindelin, H.
Deposit date:2021-10-01
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Commun Chem, 5, 2022
7R7T
DownloadVisualize
BU of 7r7t by Molmil
p47-bound p97-R155H mutant with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2021-06-25
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7R7S
DownloadVisualize
BU of 7r7s by Molmil
p47-bound p97-R155H mutant with ATPgammaS
Descriptor: NSFL1 cofactor p47, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2021-06-25
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4.23 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
7R7U
DownloadVisualize
BU of 7r7u by Molmil
D1 and D2 domain structure of the p97(R155H)-p47 complex
Descriptor: Transitional endoplasmic reticulum ATPase
Authors:Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Poh, Y.-P, Chou, T.-F, Chiu, P.-L.
Deposit date:2021-06-25
Release date:2021-08-04
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
8B5R
DownloadVisualize
BU of 8b5r by Molmil
p97-p37-SPI substrate complex
Descriptor: I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ...
Authors:van den Boom, J, Marini, G, Meyer, H, Saibil, H.
Deposit date:2022-09-24
Release date:2023-06-07
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
Embo J., 42, 2023
6MDO
DownloadVisualize
BU of 6mdo by Molmil
The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ...
Authors:White, K.I, Zhao, M, Brunger, A.T.
Deposit date:2018-09-04
Release date:2018-09-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
6MDP
DownloadVisualize
BU of 6mdp by Molmil
The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ...
Authors:White, K.I, Zhao, M, Brunger, A.T.
Deposit date:2018-09-04
Release date:2018-09-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
6MDN
DownloadVisualize
BU of 6mdn by Molmil
The 20S supercomplex engaging the SNAP-25 N-terminus (class 2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ...
Authors:White, K.I, Zhao, M, Brunger, A.T.
Deposit date:2018-09-04
Release date:2018-09-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
6MDM
DownloadVisualize
BU of 6mdm by Molmil
The 20S supercomplex engaging the SNAP-25 N-terminus (class 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ...
Authors:White, K.I, Zhao, M, Brunger, A.T.
Deposit date:2018-09-04
Release date:2018-09-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
8DAT
DownloadVisualize
BU of 8dat by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (intB)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAU
DownloadVisualize
BU of 8dau by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two folded ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (uA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAV
DownloadVisualize
BU of 8dav by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uC)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAW
DownloadVisualize
BU of 8daw by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uD)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAS
DownloadVisualize
BU of 8das by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two ubiquitin moieties in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (intA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAR
DownloadVisualize
BU of 8dar by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex unbound but in the presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
6OA9
DownloadVisualize
BU of 6oa9 by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OAA
DownloadVisualize
BU of 6oaa by Molmil
Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A.
Deposit date:2019-03-15
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
Science, 365, 2019
6OMB
DownloadVisualize
BU of 6omb by Molmil
Cdc48 Hexamer (Subunits A to E) with substrate bound to the central pore
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ...
Authors:Cooney, I, Han, H, Stewart, M, Carson, R.H, Hansen, D, Price, J.C, Hill, C.P, Shen, P.S.
Deposit date:2019-04-18
Release date:2019-07-17
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
Science, 365, 2019
8FCP
DownloadVisualize
BU of 8fcp by Molmil
Cryo-EM structure of p97:UBXD1 para state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCO
DownloadVisualize
BU of 8fco by Molmil
Cryo-EM structure of p97:UBXD1 meta state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCQ
DownloadVisualize
BU of 8fcq by Molmil
Cryo-EM structure of p97:UBXD1 PUB-in state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCN
DownloadVisualize
BU of 8fcn by Molmil
Cryo-EM structure of p97:UBXD1 VIM-only state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCT
DownloadVisualize
BU of 8fct by Molmil
Cryo-EM structure of p97:UBXD1 lariat mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCL
DownloadVisualize
BU of 8fcl by Molmil
Cryo-EM structure of p97:UBXD1 closed state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCR
DownloadVisualize
BU of 8fcr by Molmil
Cryo-EM structure of p97:UBXD1 H4-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon