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4X38	Gallus interleukin-1 beta mutant - E118A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Gallus interleukin-1 beta mutant - E118A To Be Published
4X39	Gallus interleukin-1 beta mutant - T117A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Gallus interleukin-1 beta mutant - T117A To Be Published
4XFT	Structure of IL-18 SER Mutant III Descriptor: DIMETHYL SULFOXIDE, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFU	Structure of IL-18 SER Mutant V Descriptor: Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFS	Structure of IL-18 SER Mutant I Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-28 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4EKX	Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 Descriptor: 14L protein, Interleukin-18 Authors: Krumm, B.E, Xiang, Y, Deng, J. Deposit date: 2012-04-10 Release date: 2012-09-26 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Plos Pathog., 8, 2012
4G6J	Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.03 Å) Cite: One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425, 2013
4G6M	Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab Descriptor: Interleukin-1 beta, heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment Authors: Blech, M, Hoerer, S. Deposit date: 2012-07-19 Release date: 2012-12-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab J.Mol.Biol., 425, 2013
4GAI	Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra Descriptor: EBI-005 Authors: Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. Deposit date: 2012-07-25 Release date: 2013-02-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
4HJJ	Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule Descriptor: Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... Authors: Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. Deposit date: 2012-10-12 Release date: 2013-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
4I1B	FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE Descriptor: INTERLEUKIN-1 BETA Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Raag, R, Svensson, L.A, Masui, Y, Hirai, Y. Deposit date: 1990-03-27 Release date: 1990-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional implications of interleukin-1 beta based on the three-dimensional structure. Proteins, 12, 1992
4IZE	Crystal Structure of IL-36gamma Descriptor: Interleukin-36 gamma Authors: Guenther, S, Sundberg, E.J. Deposit date: 2013-01-29 Release date: 2014-06-25 Last modified: 2014-07-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J.Immunol., 193, 2014
1HIB	THE STRUCTURE OF AN INTERLEUKIN-1 BETA MUTANT WITH REDUCED BIOACTIVITY SHOWS MULTIPLE SUBTLE CHANGES IN CONFORMATION THAT AFFECT PROTEIN-PROTEIN RECOGNITION Descriptor: INTERLEUKIN-1 BETA Authors: Camacho, N.P, Smith, D.R, Goldman, A, Schneider, B, Green, D, Young, P.R, Berman, H.M. Deposit date: 1993-03-29 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry, 32, 1993
1I1B	CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION Descriptor: INTERLEUKIN-1 BETA Authors: Finzel, B.C, Watenpaugh, K.D, Einspahr, H.M. Deposit date: 1989-12-05 Release date: 1990-01-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of recombinant human interleukin-1 beta at 2.0 A resolution. J.Mol.Biol., 209, 1989
1J0S	Solution structure of the human interleukin-18 Descriptor: Interleukin-18 Authors: Kato, Z, Jee, J, Shikano, H, Mishima, M, Ohki, I, Yoneda, T, Hara, T, Torigoe, K, Kondo, N, Shirakawa, M. Deposit date: 2002-11-21 Release date: 2003-11-11 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: The structure and binding mode of interleukin-18 Nat.Struct.Biol., 10, 2003
1IOB	INTERLEUKIN-1 BETA FROM JOINT X-RAY AND NMR REFINEMENT Descriptor: INTERLEUKIN-1 BETA Authors: Shaanan, B, Clore, G.M. Deposit date: 1996-03-14 Release date: 1996-08-17 Last modified: 2011-07-13 Method: SOLUTION NMR (2 Å), X-RAY DIFFRACTION Cite: Combining experimental information from crystal and solution studies: joint X-ray and NMR refinement. Science, 257, 1992
1ILT	X-RAY STRUCTURE OF INTERLEUKIN-1 RECEPTOR ANTAGONIST AT 2.0 ANGSTROMS RESOLUTION Descriptor: INTERLEUKIN-1 RECEPTOR ANTAGONIST Authors: Brandhuber, B.J, Vigers, G.P.A. Deposit date: 1994-03-09 Release date: 1995-04-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution. J.Biol.Chem., 269, 1994
1ILR	CRYSTAL STRUCTURE OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST Descriptor: INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN Authors: Schreuder, H.A, Rondeau, J.-M, Tardif, C. Deposit date: 1994-06-20 Release date: 1995-02-07 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline. Eur.J.Biochem., 227, 1995
1IRP	SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN Descriptor: INTERLEUKIN-1 RECEPTOR ANTAGONIST Authors: Stockman, B.J, Scahill, T.A, Strakalaitis, N.A. Deposit date: 1994-10-18 Release date: 1995-02-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of human interleukin-1 receptor antagonist protein. FEBS Lett., 349, 1994
1L2H	Crystal structure of Interleukin 1-beta F42W/W120F mutant Descriptor: Interleukin 1-beta Authors: Rudolph, M.G, Kelker, M.S, Schneider, T.R, Yeates, T.O, Oseroff, V, Heidary, D.K, Jennings, P.A, Wilson, I.A. Deposit date: 2002-02-21 Release date: 2003-02-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta. Acta Crystallogr.,Sect.D, 59, 2003
1MD6	High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity Descriptor: interleukin 1 family, member 5 (delta) Authors: Pei, X.Y, Dunn, E.F, Gay, N.J, O'Neill, L.A. Deposit date: 2002-08-07 Release date: 2003-09-30 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity. Biochemistry, 42, 2003
5R8D	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1745658474 in complex with INTERLEUKIN-1 BETA Descriptor: 2-(trifluoromethyl)pyrimidine-5-carboxamide, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R87	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z44592329 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, N-phenyl-N'-pyridin-3-ylurea, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8L	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1891773393 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, N-{4-[(1S)-1-aminoethyl]phenyl}cyclopropanecarboxamide, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8I	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z210803634 in complex with INTERLEUKIN-1 BETA Descriptor: (1~{R})-1-(4-ethoxyphenyl)ethanamine, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

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