PDB: 603 resultsInfo pagesStatus searchChemie searchBIRD

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1QJB	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) Descriptor: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE Authors: Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. Deposit date: 1999-06-23 Release date: 1999-09-15 Last modified: 2018-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
1QJA	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) Descriptor: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE Authors: Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. Deposit date: 1999-06-23 Release date: 1999-09-15 Last modified: 2018-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
6HMT	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 2 Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen Receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-12 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HKB	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 3 Descriptor: (1~{R},2~{S})-2-[methyl-[(~{R})-(2-methylpropan-2-yl)oxy-oxidanyl-methyl]amino]-2-phenyl-1-(2-sulfanylethylamino)ethanol, 14-3-3 protein sigma, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-06 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HHP	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 1 Descriptor: (1~{R})-2-(4-chloranylphenoxy)-2-methyl-1-[methyl(2-sulfanylethyl)amino]propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-08-28 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HKF	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 4 Descriptor: (1~{S})-2,2-diphenyl-1-(2-sulfanylethylamino)propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-06 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.801 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HMU	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6 Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(3-sulfanylpropyl)propanamide, Estrogen receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-12 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6KZH	14-3-3 protein in Complex with CIC S173 phosphorylated peptide Descriptor: 14-3-3 protein theta, CIC pS173 peptide Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.645 Å) Cite: 14-3-3 protein in Complex with CIC S173 phosphorylated peptide To Be Published
6KZG	14-3-3 protein in Complex with CIC S301 phosphorylated peptide Descriptor: 14-3-3 protein theta, ARG-SER-MET-SER-GLU-THR-GLY-THR Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: 14-3-3 protein in Complex with CIC S301 phosphorylated peptide To Be Published
5BTV	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Ottmann, C, Schumacher, B, Bartel, M. Deposit date: 2015-06-03 Release date: 2016-07-20 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5D2D	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-05 Release date: 2016-03-16 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
8Q1S	Pathogenic mutations of human phosphorylation sites affect protein-protein interactions Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... Authors: Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. Deposit date: 2023-08-01 Release date: 2024-02-21 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (3.23 Å) Cite: Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
8P1H	Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor Descriptor: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... Authors: Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. Deposit date: 2023-05-12 Release date: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. Deposit date: 2023-05-10 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. Descriptor: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-13 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5F74	Crystal structure of ChREBP:14-3-3 complex bound with AMP Descriptor: 14-3-3 protein beta/alpha, ADENOSINE MONOPHOSPHATE, Carbohydrate-responsive element-binding protein Authors: Jung, H, Uyeda, K. Deposit date: 2015-12-07 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J.Biol.Chem., 291, 2016
5NWI	14-3-3c in complex with CPP Descriptor: 14-3-3 c-1 protein, ACETATE ION, Potassium channel KAT1 Authors: Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. Deposit date: 2017-05-06 Release date: 2017-11-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017

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