6L2C
 
 | | Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase in complex with CoA | | Descriptor: | Acetyl-CoA-acetyltransferase, putative, COENZYME A | | Authors: | Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W. | | Deposit date: | 2019-10-03 | | Release date: | 2020-02-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
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7YVY
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6HSJ
 | | Crystal structure of the zebrafish peroxisomal SCP2-thiolase (type-1) in complex with CoA | | Descriptor: | ACETATE ION, COENZYME A, GLYCEROL, ... | | Authors: | Wierenga, R.K, Kiema, T.R, Thapa, C.J. | | Deposit date: | 2018-10-01 | | Release date: | 2019-01-02 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
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7YXM
 | | Benzoylsuccinyl-CoA thiolase with coenzyme A | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Benzoylsuccinyl-CoA thiolase subunit, ... | | Authors: | Ermler, U, Heider, J, Weidenweber, S. | | Deposit date: | 2022-02-16 | | Release date: | 2022-04-06 | | Last modified: | 2022-09-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
Febs J., 289, 2022
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2F2S
 | | Human mitochondrial acetoacetyl-CoA thiolase | | Descriptor: | Acetyl-CoA acetyltransferase, mitochondrial, CHLORIDE ION, ... | | Authors: | Min, J.R, Dombrovski, L, Antoshenko, T, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2005-11-17 | | Release date: | 2005-11-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Crystal Structure of Human Mitochondrial Acetoacetyl-Coa Thiolase Acat1.
To be Published
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5LOT
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5LNQ
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5M3K
 | | A multi-component acyltransferase PhlABC from Pseudomonas protegens | | Descriptor: | 2,4-diacetylphloroglucinol biosynthesis protein PhlB, 2,4-diacetylphloroglucinol biosynthesis protein PhlC, PhlA, ... | | Authors: | Pavkov-Keller, T, Schmidt, N.G, Kroutil, W, Gruber, K. | | Deposit date: | 2016-10-15 | | Release date: | 2017-12-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.
Chembiochem, 20, 2019
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5LP7
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6OK1
 | | Ltp2-ChsH2(DUF35) aldolase | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ChsH2(DUF35), ... | | Authors: | Kimber, M.S, Mallette, E, Aggett, R, Seah, S.Y.K. | | Deposit date: | 2019-04-12 | | Release date: | 2019-06-26 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The steroid side-chain-cleaving aldolase Ltp2-ChsH2DUF35is a thiolase superfamily member with a radically repurposed active site.
J.Biol.Chem., 294, 2019
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6PCA
 | | Crystal structure of beta-ketoadipyl-CoA thiolase | | Descriptor: | ACETATE ION, Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, ... | | Authors: | Sukritee, B, Panjikar, S. | | Deposit date: | 2019-06-17 | | Release date: | 2020-05-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
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6PCB
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6PCC
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6PCD
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3SVK
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3SS6
 | | Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase | | Descriptor: | Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION | | Authors: | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-07-07 | | Release date: | 2011-07-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
TO BE PUBLISHED
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1ULQ
 | | Crystal structure of tt0182 from Thermus thermophilus HB8 | | Descriptor: | putative acetyl-CoA acetyltransferase | | Authors: | Ago, H, Hamada, K, Ida, K, Kanda, H, Sugahara, M, Yamamoto, M, Kuroishi, C, Kuramitsu, S, Yokoyama, S, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-09-16 | | Release date: | 2004-11-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of tt0182 from Thermus thermophilus HB8
To be Published
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1WDL
 | | fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form II (native4) | | Descriptor: | 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, ... | | Authors: | Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K. | | Deposit date: | 2004-05-17 | | Release date: | 2004-07-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex
Embo J., 23, 2004
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1WDK
 | | fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native2) | | Descriptor: | 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, ... | | Authors: | Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K. | | Deposit date: | 2004-05-17 | | Release date: | 2004-07-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex
Embo J., 23, 2004
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1WDM
 | | fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native3) | | Descriptor: | 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, Fatty oxidation complex alpha subunit, ... | | Authors: | Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K. | | Deposit date: | 2004-05-17 | | Release date: | 2004-07-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex
Embo J., 23, 2004
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1WL4
 | | Human cytosolic acetoacetyl-CoA thiolase complexed with CoA | | Descriptor: | COENZYME A, GLYCEROL, SULFATE ION, ... | | Authors: | Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K. | | Deposit date: | 2004-06-20 | | Release date: | 2005-03-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I
J.Mol.Biol., 347, 2005
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1WL5
 | | Human cytosolic acetoacetyl-CoA thiolase | | Descriptor: | GLYCEROL, SULFATE ION, acetyl-Coenzyme A acetyltransferase 2 | | Authors: | Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K. | | Deposit date: | 2004-06-20 | | Release date: | 2005-03-01 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I
J.Mol.Biol., 347, 2005
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3ZBN
 | | Crystal structure of SCP2 thiolase from Leishmania mexicana. Complex of the C123A mutant with Coenzyme A. | | Descriptor: | 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, COENZYME A | | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | | Deposit date: | 2012-11-11 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
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3ZBG
 | | Crystal structure of wild-type SCP2 thiolase from Leishmania mexicana at 1.85 A | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, DIMETHYL SULFOXIDE | | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | | Deposit date: | 2012-11-09 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
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3ZBL
 | | Crystal structure of SCP2 thiolase from Leishmania mexicana: The C123S mutant. | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, CHLORIDE ION, ... | | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | | Deposit date: | 2012-11-10 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
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