1J19
 
 | | Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide | | Descriptor: | 16-mer peptide from Intercellular adhesion molecule-2, radixin | | Authors: | Hamada, K, Shimizu, T, Yonemura, S, Tsukita, S, Tsukita, S, Hakoshima, T. | | Deposit date: | 2002-12-02 | | Release date: | 2003-03-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex
EMBO J., 22, 2003
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2HE7
 | | FERM domain of EPB41L3 (DAL-1) | | Descriptor: | Band 4.1-like protein 3 | | Authors: | Hallberg, B.M, Busam, R.D, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Schiavone, L.H, Johansson, I, Hogbom, M, Karlberg, T, Kotenyova, T, Nilvebrandt, J, Norberg, P, Stenmark, P, Nordlund, P, Nilsson-ehle, P, Nyman, T, Ogg, D, Sagemark, J, Sundstrom, M, Uppenberg, J, Van den berg, S, Weigelt, J, Persson, C, Thorsell, A.G, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-06-21 | | Release date: | 2006-07-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).
J.Biol.Chem., 286, 2011
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3U8Z
 | | human merlin FERM domain | | Descriptor: | Merlin | | Authors: | Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T. | | Deposit date: | 2011-10-17 | | Release date: | 2011-11-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Protein Sci., 20, 2011
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6T36
 | | Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide | | Descriptor: | BROMIDE ION, Capsid protein, Tyrosine-protein phosphatase non-receptor type 3 | | Authors: | Genera, M, Mechaly, A, Haouz, A, Caillet-Saguy, C. | | Deposit date: | 2019-10-10 | | Release date: | 2021-01-20 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Sci Rep, 11, 2021
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2I1J
 | | Moesin from Spodoptera frugiperda at 2.1 angstroms resolution | | Descriptor: | CHLORIDE ION, GLYCEROL, Moesin, ... | | Authors: | Li, Q, Nance, M.R, Tesmer, J.J.G. | | Deposit date: | 2006-08-14 | | Release date: | 2006-12-19 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain.
J.Mol.Biol., 365, 2007
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2I1K
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3WA0
 | | Crystal structure of merlin complexed with DCAF1/VprBP | | Descriptor: | Merlin, Protein VPRBP | | Authors: | Mori, T, Gotoh, S, Shirakawa, M, Hakoshima, T. | | Deposit date: | 2013-04-20 | | Release date: | 2014-05-28 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Genes Cells, 19, 2014
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3X23
 | | Radixin complex | | Descriptor: | Peptide from Matrix metalloproteinase-14, Radixin | | Authors: | Terawaki, S, Kitano, K, Aoyama, M, Mori, T, Hakoshima, T. | | Deposit date: | 2014-12-09 | | Release date: | 2015-10-21 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | MT1-MMP recognition by ERM proteins and its implication in CD44 shedding
Genes Cells, 20, 2015
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8CIT
 | | The FERM domain of human moesin mutant L281R | | Descriptor: | Moesin | | Authors: | Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. | | Deposit date: | 2023-02-10 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.536 Å) | | Cite: | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
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8CIR
 | | The FERM domain of human moesin with a bound peptide identified by phage display | | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... | | Authors: | Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. | | Deposit date: | 2023-02-10 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
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8CIS
 | | The FERM domain of human moesin with two bound peptides identified by phage display | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, C3P, ... | | Authors: | Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. | | Deposit date: | 2023-02-10 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
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8CIU
 | | The FERM domain of human moesin mutant H288A | | Descriptor: | Moesin | | Authors: | Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. | | Deposit date: | 2023-02-10 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.393 Å) | | Cite: | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
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4YL8
 | | Crystal structure of the Crumbs/Moesin complex | | Descriptor: | GLYCEROL, IODIDE ION, Moesin, ... | | Authors: | Wei, Z, Li, Y, Zhang, M. | | Deposit date: | 2015-03-05 | | Release date: | 2015-04-01 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin
J.Biol.Chem., 290, 2015
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4ZRK
 | | Merlin-FERM and Lats1 complex | | Descriptor: | Merlin, Serine/threonine-protein kinase LATS1 | | Authors: | Lin, Z, Li, Y, Wei, Z, Zhang, M. | | Deposit date: | 2015-05-12 | | Release date: | 2015-06-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.316 Å) | | Cite: | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Cell Res., 25, 2015
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4ZRI
 | | Crystal structure of Merlin-FERM and Lats2 | | Descriptor: | Merlin, Serine/threonine-protein kinase LATS2 | | Authors: | Li, F, Zhou, H, Long, J, Shen, Y. | | Deposit date: | 2015-05-12 | | Release date: | 2015-06-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Cell Res., 25, 2015
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4ZRJ
 | | Structure of Merlin-FERM and CTD | | Descriptor: | GLYCEROL, Merlin | | Authors: | Lin, Z, Li, F, Long, J, Shen, Y. | | Deposit date: | 2015-05-12 | | Release date: | 2015-06-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Cell Res., 25, 2015
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1E5W
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1EF1
 | | CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX | | Descriptor: | MOESIN, SULFATE ION | | Authors: | Pearson, M.A, Reczek, D, Bretscher, A, Karplus, P.A. | | Deposit date: | 2000-02-04 | | Release date: | 2000-05-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain.
Cell(Cambridge,Mass.), 101, 2000
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1GG3
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1GC7
 | | CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN | | Descriptor: | RADIXIN | | Authors: | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | | Deposit date: | 2000-07-21 | | Release date: | 2000-09-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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1GC6
 | | CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE | | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, RADIXIN | | Authors: | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | | Deposit date: | 2000-07-21 | | Release date: | 2000-09-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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2D10
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2D11
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2D2Q
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2EMS
 | | Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule CD43 | | Descriptor: | Leukosialin, Radixin | | Authors: | Takai, Y, Kitano, K, Terawaki, S, Maesaki, R, Hakoshima, T. | | Deposit date: | 2007-03-28 | | Release date: | 2008-04-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins
J.Mol.Biol., 381, 2008
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