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2BX7
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BU of 2bx7 by Molmil
Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,5-dihydroxybenzoate
Descriptor: 3,5-DIHYDROXYBENZOATE, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
Authors:Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A.
Deposit date:2005-07-25
Release date:2006-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis.
Biochemistry, 46, 2007
2BXV
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BU of 2bxv by Molmil
Dual binding mode of a novel series of DHODH inhibitors
Descriptor: 2-({[3-FLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
Authors:Baumgartner, R, Walloschek, M, Karlik, M, Gotschlich, A, Tasler, S, Mies, J, Leban, J.
Deposit date:2005-07-27
Release date:2006-08-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J. Med. Chem., 49, 2006
2DJL
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BU of 2djl by Molmil
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate
Descriptor: COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-04-04
Release date:2007-06-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate
To be Published
2DJX
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BU of 2djx by Molmil
Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
Descriptor: COBALT HEXAMMINE(III), Dihydroorotate Dehydrogenase, FLAVIN MONONUCLEOTIDE
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-04-05
Release date:2007-06-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase
To be Published
2DOR
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BU of 2dor by Molmil
DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS COMPLEXED WITH OROTATE
Descriptor: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, OROTIC ACID
Authors:Rowland, P, Larsen, S.
Deposit date:1998-05-11
Release date:1998-08-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.
Protein Sci., 7, 1998
2E68
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BU of 2e68 by Molmil
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, ...
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
To be Published
2E6A
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BU of 2e6a by Molmil
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate
Descriptor: COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate
To be Published
2E6D
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BU of 2e6d by Molmil
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with fumarate
Descriptor: COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction
Biochemistry, 47, 2008
2E6F
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BU of 2e6f by Molmil
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate
Descriptor: COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K.
Deposit date:2006-12-26
Release date:2008-01-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate
To be Published
2FPT
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BU of 2fpt by Molmil
Dual Binding Mode of a Novel Series of DHODH inhibitors
Descriptor: 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ...
Authors:Baumgartner, R, Walloschek, M, Kralik, M, Gotschlich, A, Tasler, S, Leban, J.
Deposit date:2006-01-17
Release date:2007-01-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FPV
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BU of 2fpv by Molmil
Dual binding mode of a novel series of DHODH inhibitors
Descriptor: 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ...
Authors:Baumgartner, R, Leban, J.
Deposit date:2006-01-17
Release date:2007-01-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FPY
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BU of 2fpy by Molmil
Dual binding mode of a novel series of DHODH inhibitors
Descriptor: 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ...
Authors:Baumgartner, R, Leban, J.
Deposit date:2006-01-17
Release date:2007-01-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2FQI
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BU of 2fqi by Molmil
dual binding modes of a novel series of DHODH inhibitors
Descriptor: 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ...
Authors:Baumgartner, R, Leban, J.
Deposit date:2006-01-18
Release date:2007-01-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Dual binding mode of a novel series of DHODH inhibitors.
J.Med.Chem., 49, 2006
2PRH
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BU of 2prh by Molmil
The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Descriptor: 6-CHLORO-2-(2'-FLUOROBIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, Dihydroorotate dehydrogenase, ...
Authors:Walse, B, Dufe, V.T, Al-Karadaghi, S.
Deposit date:2007-05-04
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry, 47, 2008
2PRL
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BU of 2prl by Molmil
The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Descriptor: 5-METHOXY-2-[(4-PHENOXYPHENYL)AMINO]BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
Authors:Walse, B, Dufe, V.T, Al-Karadaghi, S.
Deposit date:2007-05-04
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry, 47, 2008
2PRM
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BU of 2prm by Molmil
The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Descriptor: Dihydroorotate dehydrogenase, mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Walse, B, Dufe, V.T, Al-Karadaghi, S.
Deposit date:2007-05-04
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Biochemistry, 47, 2008
2WV8
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BU of 2wv8 by Molmil
Complex of human dihydroorotate dehydrogenase with the inhibitor 221290
Descriptor: 2-ACETAMIDO-5-(4-PHENYLPHENYL)BENZOIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
Authors:Walse, B, Svensson, B, Fritzson, I, Dahlberg, L, Wellmar, U, Al-Karadaghi, S.
Deposit date:2009-10-15
Release date:2010-08-25
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection.
Chemmedchem, 5, 2010
3C3N
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BU of 3c3n by Molmil
Crystal structure of dihydroorotate dehydrogenase from Trypanosoma cruzi strain Y
Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Pinheiro, M.P, Iulek, J, Nonato, M.C.
Deposit date:2008-01-28
Release date:2008-04-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain
Biochem.Biophys.Res.Commun., 369, 2008
3C61
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BU of 3c61 by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania donovani
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, AZIDE ION, CHLORIDE ION, ...
Authors:Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-02-01
Release date:2008-02-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dihydroorotate dehydrogenase from Leishmania donovani.
To be Published
3F1Q
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BU of 3f1q by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1
Descriptor: (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ...
Authors:Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P.
Deposit date:2008-10-28
Release date:2009-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3FJ6
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BU of 3fj6 by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2
Descriptor: (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETATE ION, Dihydroorotate dehydrogenase, ...
Authors:Heikkila, T.
Deposit date:2008-12-14
Release date:2009-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3FJL
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BU of 3fjl by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3
Descriptor: (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ...
Authors:Heikkila, T.
Deposit date:2008-12-14
Release date:2009-06-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3G0U
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BU of 3g0u by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4
Descriptor: (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Davis, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P.
Deposit date:2009-01-28
Release date:2009-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3G0X
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BU of 3g0x by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5
Descriptor: (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Davies, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P.
Deposit date:2009-01-29
Release date:2009-06-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3GYE
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BU of 3gye by Molmil
Didydroorotate dehydrogenase from Leishmania major
Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
Authors:Cordeiro, A.T, Feliciano, P.R, Nonato, M.C.
Deposit date:2009-04-03
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Leishmania major Dihydroorotate dehydrogenase
To be Published

217705

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