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5YBD
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BU of 5ybd by Molmil
X-ray structure of ETS domain of Ergp55 in complex with E74DNA
Descriptor: DNA (5'-D(P*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), DNA (5'-D(P*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), Transcriptional regulator ERG
Authors:Saxena, A.K, Gangwar, S.P.
Deposit date:2017-09-04
Release date:2018-11-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.769 Å)
Cite:Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence
Acta Crystallogr F Struct Biol Commun, 74, 2018
4IRI
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BU of 4iri by Molmil
Auto-inhibited ERG Ets Domain-DNA Complex
Descriptor: DNA (5'-D(*CP*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP*G)-3'), Transcriptional regulator ERG
Authors:Regan, M.C, Horanyi, P.S, Pryor, E.E, Sarver, J.L, Cafiso, D.S, Bushweller, J.H.
Deposit date:2013-01-14
Release date:2013-07-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited.
Proc.Natl.Acad.Sci.USA, 110, 2013
4IRG
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BU of 4irg by Molmil
Uninhibited DNA-binding domain of the Ets transcription factor ERG
Descriptor: Transcriptional regulator ERG
Authors:Regan, M.C, Horanyi, P.S, Pryor, E.E, Sarver, J.L, Cafiso, D.S, Bushweller, J.H.
Deposit date:2013-01-14
Release date:2013-07-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited.
Proc.Natl.Acad.Sci.USA, 110, 2013
4IRH
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BU of 4irh by Molmil
Auto-inhibited ERG Ets domain
Descriptor: Transcriptional regulator ERG
Authors:Regan, M.C, Horanyi, P.S, Pryor, E.E, Sarver, J.L, Cafiso, D.S, Bushweller, J.H.
Deposit date:2013-01-14
Release date:2013-07-31
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited.
Proc.Natl.Acad.Sci.USA, 110, 2013
8SP1
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BU of 8sp1 by Molmil
Chimeric ETS-domain of murine PU.1 harboring the corresponding beta-strand 3 (S3) residues from murine Ets-1 in complex with d(AATAAGCGIAAGTGGG)
Descriptor: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ...
Authors:Terrell, J.R, Poon, G.M.K.
Deposit date:2023-05-01
Release date:2023-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors.
Structure, 32, 2024
8T9U
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BU of 8t9u by Molmil
Human PU.1 ETS-domain (165-270) in complex with d(AATAAGCGIAAGTGGG)
Descriptor: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ...
Authors:Terrell, J.R, Poon, G.M.K.
Deposit date:2023-06-26
Release date:2023-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors.
Structure, 32, 2024
8SMH
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BU of 8smh by Molmil
Chimeric ETS-domain of murine PU.1 harboring the corresponding beta-strand 3 (S3) residues from murine Ets-1 in complex with d(AATAAGCGGAAGTGGG)
Descriptor: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ...
Authors:Terrell, J.R, Poon, G.M.K.
Deposit date:2023-04-26
Release date:2023-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors.
Structure, 32, 2024
8SMJ
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BU of 8smj by Molmil
Chimeric ETS-domain of murine PU.1 harboring the corresponding beta-strand 3 (S3) residues from murine Ets-1 in complex with d(AATAAGCGGAATGGGG)
Descriptor: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*TP*GP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*CP*AP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), Transcription factor PU.1
Authors:Terrell, J.R, Poon, G.M.K.
Deposit date:2023-04-26
Release date:2023-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors.
Structure, 32, 2024
2MD5
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BU of 2md5 by Molmil
Structure of uninhibited ETV6 ETS domain
Descriptor: Transcription factor ETV6
Authors:De, S, Mcintosh, L.P, Chan, A.C, Coyne, H.J, Okon, M, Graves, B.J, Murphy, M.E.
Deposit date:2013-08-29
Release date:2013-12-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426, 2014
2NNY
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BU of 2nny by Molmil
Crystal structure of the Ets1 dimer DNA complex.
Descriptor: 5'-D(*A*CP*TP*CP*CP*AP*GP*GP*AP*AP*GP*TP*GP*CP*TP*TP*CP*CP*TP*GP*TP*CP*T)-3', 5'-D(*T*AP*GP*AP*CP*AP*GP*GP*AP*AP*GP*CP*AP*CP*TP*TP*CP*CP*TP*GP*GP*AP*G)-3', C-ets-1 protein
Authors:Lamber, E.P, Kachalova, G.S, Wilmanns, M.
Deposit date:2006-10-24
Release date:2008-03-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.
Embo J., 27, 2008
5ILS
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BU of 5ils by Molmil
Autoinhibited ETV1
Descriptor: ETS translocation variant 1
Authors:Whitby, F.G, Currie, S.L.
Deposit date:2016-03-04
Release date:2017-02-22
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
5ILV
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BU of 5ilv by Molmil
Uninhibited ETV5
Descriptor: ETS translocation variant 5
Authors:Whitby, F.G, Currie, S.L.
Deposit date:2016-03-04
Release date:2017-02-22
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
5ILU
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BU of 5ilu by Molmil
Autoinhibited ETV4
Descriptor: ETS translocation variant 4
Authors:Whitby, F.G, Currie, S.L.
Deposit date:2016-03-04
Release date:2017-02-22
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
5JVT
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BU of 5jvt by Molmil
Crystal structure of the DNA binding domain of transcription factor FLI1 in complex with an 11-mer DNA GACCGGAAGTG
Descriptor: DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), Friend leukemia integration 1 transcription factor, ...
Authors:Hou, C, Tsodikov, O.V.
Deposit date:2016-05-11
Release date:2016-09-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
Nucleic Acids Res., 44, 2016
2STW
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BU of 2stw by Molmil
SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, RESTRAINED REGULARIZED MEAN STRUCTURE
Descriptor: DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'), ETS1
Authors:Clore, G.M, Werner, M.H, Gronenborn, A.M.
Deposit date:1996-08-05
Release date:1997-03-12
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Correction of the NMR structure of the ETS1/DNA complex.
J.Biomol.NMR, 10, 1997
2STT
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BU of 2stt by Molmil
SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, 25 STRUCTURES
Descriptor: DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'), ETS1
Authors:Clore, G.M, Werner, M.H, Gronenborn, A.M.
Deposit date:1996-08-05
Release date:1997-03-12
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Correction of the NMR structure of the ETS1/DNA complex.
J.Biomol.NMR, 10, 1997
3ZP5
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BU of 3zp5 by Molmil
Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA
Descriptor: 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', PROTEIN FEV
Authors:Newman, J.A, Cooper, C.D.O, Krojer, T, Shrestha, L, Allerston, C.K, Vollmar, M, Arrowsmith, C.H, Burgess-Brown, N, Edwards, A, von Delft, F, Gileadi, O.
Deposit date:2013-02-26
Release date:2013-03-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4MHG
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BU of 4mhg by Molmil
Crystal structure of ETV6 bound to a specific DNA sequence
Descriptor: Complementary Specific 14 bp DNA, Specific 14 bp DNA, Transcription factor ETV6
Authors:Chan, A.C, De, S, Coyne III, H.J, Okon, M, Murphy, M.E, Graves, B.J, McIntosh, L.P.
Deposit date:2013-08-29
Release date:2014-01-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426, 2014
4AVP
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BU of 4avp by Molmil
Crystal structure of the DNA-binding domain of human ETV1.
Descriptor: 1,2-ETHANEDIOL, ETS TRANSLOCATION VARIANT 1
Authors:Allerston, C.K, Cooper, C.D.O, Krojer, T, Chaikuad, A, Filippakopoulos, P, Canning, P, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Gileadi, O.
Deposit date:2012-05-28
Release date:2012-06-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4BNC
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BU of 4bnc by Molmil
Crystal structure of the DNA-binding domain of human ETV1 complexed with DNA
Descriptor: 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', HUMAN ETV1
Authors:Allerston, C.K, Cooper, C.D.O, Krojer, T, Chaikuad, A, Vollmar, M, Froese, D.S, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Gileadi, O.
Deposit date:2013-05-14
Release date:2013-07-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4BQA
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BU of 4bqa by Molmil
Crystal structure of the ETS domain of human ETS2 in complex with DNA
Descriptor: 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', PROTEIN C-ETS-2
Authors:Newman, J.A, Cooper, C.D.O, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Gileadi, O.
Deposit date:2013-05-30
Release date:2013-06-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2.
J.Biol.Chem., 290, 2015
6VG2
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BU of 6vg2 by Molmil
Crystal structure of the DNA binding domain of human transcription factor FLI1 in complex with 16-mer DNA CAGAGGATGTGGCTTC
Descriptor: DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP*GP*CP*TP*TP*C)-3'), Friend leukemia integration 1 transcription factor
Authors:Hou, C, Tsodikov, O.V.
Deposit date:2020-01-07
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Structure, 29, 2021
4CO8
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BU of 4co8 by Molmil
Structure of the DNA binding ETS domain of human ETV4
Descriptor: 1,2-ETHANEDIOL, ETS TRANSLOCATION VARIANT 4
Authors:Newman, J.A, Cooper, C.D.O, Shrestha, L, Burgess-Brown, N, Kopec, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O.
Deposit date:2014-01-27
Release date:2014-02-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
1GVJ
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BU of 1gvj by Molmil
ETS-1 DNA BINDING AND AUTOINHIBITORY DOMAINS
Descriptor: C-ETS-1 PROTEIN
Authors:Tahirov, T.H, Ogata, K.
Deposit date:2002-02-14
Release date:2004-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Crystal Structure of C-Ets-1 DNA-Binding and Autoinhibitory Domains
To be Published
1K7A
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BU of 1k7a by Molmil
Ets-1(331-440)+GGAG duplex
Descriptor: C-ets-1 Protein, DNA (5'-D(*CP*AP*CP*AP*TP*CP*TP*CP*CP*GP*GP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*CP*CP*GP*GP*AP*GP*AP*TP*GP*T)-3')
Authors:Garvie, C.W, Hagman, J, Wolberger, C.
Deposit date:2001-10-18
Release date:2002-01-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001

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PDB entries from 2024-03-27

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