PDB: 117 resultsInfo pagesStatus searchChemie searchBIRD

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4ONJ	Crystal structure of the catalytic domain of ntDRM Descriptor: DNA methyltransferase, SINEFUNGIN Authors: Du, J, Patel, D.J. Deposit date: 2014-01-28 Release date: 2014-06-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.807 Å) Cite: Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014
4ONQ	Crystal structure of ntDRM E283S/R309S/F310S/Y590S/D591S mutant Descriptor: DNA methyltransferase, SINEFUNGIN Authors: Du, J, Patel, D.J. Deposit date: 2014-01-28 Release date: 2014-06-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014
1M0E	ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE Descriptor: 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ... Authors: Zhou, L, Cheng, X, Connolly, B.A, Dickman, M.J, Hurd, P.J, Hornby, D.P. Deposit date: 2002-06-12 Release date: 2002-09-18 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES J.MOL.BIOL., 321, 2002
1MHT	COVALENT TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE, DNA AND S-ADENOSYL-L-HOMOCYSTEINE Descriptor: DNA (5'-D(*TP*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ... Authors: Cheng, X. Deposit date: 1994-12-08 Release date: 1995-06-03 Last modified: 2018-04-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: HhaI methyltransferase flips its target base out of the DNA helix. Cell(Cambridge,Mass.), 76, 1994
8C59	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C57	CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C58	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C56	CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
4H0N	Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant Descriptor: CALCIUM ION, DNMT2, S-ADENOSYL-L-HOMOCYSTEINE Authors: Li, S, Du, J, Yang, H, Yin, J, Zhong, J, Ding, J. Deposit date: 2012-09-09 Release date: 2012-11-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.712 Å) Cite: Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol, 5, 2013
3EEO	M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. Descriptor: 5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ... Authors: Porta, J.C, Christman, J.K, Borgstahl, G.E.O. Deposit date: 2008-09-05 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.94 Å) Cite: M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. To be Published
2C7P	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... Authors: Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7O	HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH Descriptor: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7R	HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH Descriptor: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7Q	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH Descriptor: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes Nucleic Acids Res., 33, 2005
3MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY Descriptor: DNA (5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ... Authors: O'Gara, M, Klimasauskas, S, Roberts, R.J, Cheng, X. Deposit date: 1996-07-24 Release date: 1997-01-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J.Mol.Biol., 261, 1996
3QV2	Structure Analysis of Entamoeba histolytica methyltransferase EhMeth Descriptor: 5-cytosine DNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION Authors: Schulz, E.C, Roth, H.M, Ankri, S, Ficner, R. Deposit date: 2011-02-25 Release date: 2012-04-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structure Analysis of Entamoeba histolytica Methyltransferase To be Published
8TDR	Crystal structure of the methyltransferase domain of DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-04 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain To Be Published
8TE1	Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, L(+)-TARTARIC ACID, ... Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer To Be Published
9MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX Descriptor: 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... Authors: O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. Deposit date: 1998-08-07 Release date: 1998-12-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
8TE3	Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K) To Be Published
8TE4	Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer To Be Published
8T1U	Crystal structure of the DRM2-CTA DNA complex Descriptor: DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Chen, J, Lu, J, Song, J. Deposit date: 2023-06-03 Release date: 2023-11-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.91 Å) Cite: DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2. J.Biol.Chem., 299, 2023
6KDL	Crystal structure of human DNMT3B-DNMT3L complex (I) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.274 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDP	Crystal structure of human DNMT3B-DNMT3L complex (II) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, FORMIC ACID, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020
6KDB	Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-01 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.862 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020

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