PDB: 59 resultsInfo pagesStatus searchChemie searchBIRD

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7QA3	Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound N-((2-(4-phenoxyphenyl)thiazol-5-yl)methyl)-2-(trifluoromethyl)pyridin-4-amine Descriptor: Multiple virulence factor regulator MvfR, N-[[2-(4-phenoxyphenyl)-1,3-thiazol-5-yl]methyl]-2-(trifluoromethyl)pyridin-4-amine Authors: Schmelz, S, Blankenfeldt, W. Deposit date: 2021-11-15 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Divergent Synthesis and Biological Evaluation of inverse agonists targeting PqsR To Be Published
7QA0	Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 1456 Descriptor: Multiple virulence factor regulator MvfR, ~{N}-[[2-(3-chloranyl-4-propan-2-yloxy-phenyl)-1,3-thiazol-5-yl]methyl]-2-(trifluoromethyl)pyridin-4-amine Authors: Schmelz, S, Blankenfeldt, W. Deposit date: 2021-11-15 Release date: 2022-11-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Divergent Synthesis and Biological Evaluation of inverse agonists targeting PqsR To Be Published
4GWO	Crystal structure of ligand binding domain of LysR family member,CysB in complex with sulfate from Salmonella typhimurium LT2 Descriptor: GLYCEROL, HTH-type transcriptional regulator CysB, SULFATE ION Authors: Mittal, M, Singh, A.K, Kumaran, S. Deposit date: 2012-09-03 Release date: 2013-09-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.394 Å) Cite: Crystal structure of ligand binding domain of LysR family member,CysB in complex with sulfate from Salmonella typhimurium LT2 To be Published
6G1D	Corynebacterium glutamicum OxyR C206 mutant Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... Authors: Young, D.R, Pedre, B.P, Messens, J.M. Deposit date: 2018-03-21 Release date: 2018-12-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.992 Å) Cite: Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2sensing. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6G1B	Corynebacterium glutamicum OxyR, oxidized form Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, FORMIC ACID, HYDROGEN PEROXIDE, ... Authors: Young, D.R, Pedre, B.P, Messens, J.M. Deposit date: 2018-03-21 Release date: 2018-12-05 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2sensing. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6G4R	Corynebacterium glutamicum OxyR C206S mutant, H2O2-bound Descriptor: 1,2-ETHANEDIOL, HYDROGEN PEROXIDE, Hydrogen peroxide-inducible genes activator, ... Authors: Young, D.R, Pedre, B.P, Messens, J.M. Deposit date: 2018-03-28 Release date: 2018-12-05 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2sensing. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5AE5	Structures of inactive and activated DntR provide conclusive evidence for the mechanism of action of LysR transcription factors Descriptor: GLYCEROL, LYSR-TYPE REGULATORY PROTEIN Authors: Lerche, M, Dian, C, Round, A, Lonneborg, R, Brzezinski, P, Leonard, G.A. Deposit date: 2015-08-25 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.645 Å) Cite: The Solution Configurations of Inactive and Activated Dntr Have Implications for the Sliding Dimer Mechanism of Lysr Transcription Factors. Sci.Rep., 6, 2016
5AE4	Structures of inactive and activated DntR provide conclusive evidence for the mechanism of action of LysR transcription factors Descriptor: LYSR-TYPE REGULATORY PROTEIN, THIOCYANATE ION Authors: Lerche, M, Dian, C, Round, A, Lonneborg, R, Brzezinski, P, Leonard, G.A. Deposit date: 2015-08-25 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.3 Å) Cite: The Solution Configurations of Inactive and Activated Dntr Have Implications for the Sliding Dimer Mechanism of Lysr Transcription Factors. Sci.Rep., 6, 2016
7W06	Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate (SeMet labeled), Space group C121. Descriptor: 2-methylidenebutanedioic acid, CHLORIDE ION, SULFATE ION, ... Authors: Sun, P.K, Wang, B, Wang, Z.X, Qi, S, Li, X.J. Deposit date: 2021-11-17 Release date: 2022-10-26 Last modified: 2022-11-16 Method: X-RAY DIFFRACTION (1.5 Å) Cite: A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun, 13, 2022
7W08	Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in APO form, Space group P1. Descriptor: Transcriptional regulator, LysR family Authors: Sun, P.K, Wang, B, Li, X.J. Deposit date: 2021-11-17 Release date: 2022-10-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.25 Å) Cite: A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun, 13, 2022
7W07	Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate, Space group C121. Descriptor: 2-methylidenebutanedioic acid, SULFATE ION, Transcriptional regulator, ... Authors: Sun, P.K, Wang, B, Li, X.J. Deposit date: 2021-11-17 Release date: 2022-10-26 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.48 Å) Cite: A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun, 13, 2022
2ESN	The crystal structure of probable transcriptional regulator PA0477 from Pseudomonas aeruginosa Descriptor: probable transcriptional regulator Authors: Lunin, V.V, Chang, C, Skarina, T, Gorodischenskaya, E, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2005-10-26 Release date: 2005-11-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of putative transcriptional regulator Pa0477 from Pseudomonas aeruginosa To be Published
7YHJ	Effector binding domain of LysR-Type transcription factor LrhA from E. coli Descriptor: DI(HYDROXYETHYL)ETHER, Probable HTH-type transcriptional regulator LrhA, SULFATE ION Authors: Xie, C, Jiang, X. Deposit date: 2022-07-13 Release date: 2022-08-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.237 Å) Cite: Effector binding domain of LysR-Type transcription factor LrhA from E. coli To Be Published
2H98	Crystal structure of the effector binding domain of a CatM variant, CatM(V158M) Descriptor: CHLORIDE ION, HTH-type transcriptional regulator catM Authors: Ezezika, O.C, Neidle, E.L, Momany, C. Deposit date: 2006-06-09 Release date: 2007-06-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the altered regulatory roles of three LysR-type transcritional variants of CatM and BenM: CatM(V158M), CatM(R156H) and BenM(R156H/T157S) To be Published
2H99	Crystal structure of the effector binding domain of a BenM variant (R156H,T157S) Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Ezezika, O.C, Craven, S.H, Neidle, E.L, Momany, C. Deposit date: 2006-06-09 Release date: 2007-06-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1. Mol.Microbiol., 72, 2009
2H9B	Crystal structure of the effector binding domain of a BenM variant (BenM R156H/T157S) Descriptor: CHLORIDE ION, HTH-type transcriptional regulator benM, SULFATE ION Authors: Ezezika, O.C, Craven, S.H, Neidle, E.L, Momany, C. Deposit date: 2006-06-09 Release date: 2007-06-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1. Mol.Microbiol., 72, 2009
7D98	Crystal structure of full-length CbnR complexed with the target DNA complex Descriptor: DNA (56-mer), LysR-type regulatory protein Authors: Senda, M, Giannopoulou, E, Senda, T. Deposit date: 2020-10-12 Release date: 2021-03-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Crystal structure of the full-length LysR-type transcription regulator CbnR in complex with promoter DNA. Febs J., 288, 2021
7DMW	Crystal structure of CcpC regulatory domain in complex with citrate from Bacillus amyloliquefaciens Descriptor: CITRATE ANION, CcpC Authors: Chen, J, Wang, L, Shang, F, Liu, W, Chen, Y, Lan, J, Bu, T, Bai, X, Xu, Y. Deposit date: 2020-12-08 Release date: 2021-10-27 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Functional and structural analysis of catabolite control protein C that responds to citrate. Sci Rep, 11, 2021
7DWO	Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the transcriptional activation mechanism of LTTR family members Descriptor: Predicted DNA-binding transcriptional regulator Authors: Wang, W.W, Wu, H, He, J.H, Yu, F. Deposit date: 2021-01-17 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.611 Å) Cite: Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism. Int.J.Biol.Macromol., 183, 2021
7DWN	Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the transcriptional activation mechanism of LTTR family members Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Predicted DNA-binding transcriptional regulator Authors: Wang, W.W, Wu, H, He, J.H, Yu, F. Deposit date: 2021-01-17 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism. Int.J.Biol.Macromol., 183, 2021
5Y2V	Strcutrue of the full-length CcmR complexed with 2-OG from Synechocystis PCC6803 Descriptor: 2-OXOGLUTARIC ACID, PHOSPHATE ION, Rubisco operon transcriptional regulator Authors: Jiang, Y.L, Wang, X.P, Sun, H, Cheng, W, Han, S.J, Li, W.F, Chen, Y, Zhou, C.Z. Deposit date: 2017-07-27 Release date: 2017-12-27 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YDW	Full-length structure of HypT from Salmonella typhimuriuma (hypochlorite-specific LysR-type transcriptional regulator) Descriptor: Cell density-dependent motility repressor Authors: Jo, I, Hong, S, Ahn, J, Ha, N.C. Deposit date: 2017-09-15 Release date: 2018-11-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structural basis for HOCl recognition and regulation mechanisms of HypT, a hypochlorite-specific transcriptional regulator. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5Z7H	Crystal structure of CcpE regulatory domain in citrate-bound form from Staphyloccocus aureus Descriptor: CITRATE ANION, LysR family transcriptional regulator Authors: Chen, J, Wang, L, Shang, F, Xu, Y. Deposit date: 2018-01-28 Release date: 2018-02-28 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Citrate-responsive mechanism of catabolite control protein E from Staphyloccocus aureus To Be Published
5Z72	Crystal structure of CcpC regulatory domain in complex with citrate from Bacillus amyloliquefaciens Descriptor: CITRATE ANION, CcpC, SODIUM ION Authors: Chen, J, Wang, L, Shang, F, Xu, Y. Deposit date: 2018-01-26 Release date: 2018-02-28 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Mechanistic insights from the crystal structures of a catabolite control protein C on citrate-responsive mechanism To Be Published
3FXR	Crystal structure of TsaR in complex with sulfate Descriptor: ASCORBIC ACID, GLYCEROL, LysR type regulator of tsaMBCD, ... Authors: Monferrer, D, Tralau, T, Kertesz, M.A, Kikhney, A, Svergun, D, Uson, I. Deposit date: 2009-01-21 Release date: 2010-01-26 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold Mol.Microbiol., 75, 2010

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