PDB: 729 resultsInfo pagesStatus searchChemie searchBIRD

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3QCH	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]-N-(methylsulfonyl)thiophene-2-carboxamide Descriptor: 3-[(3,4-dichlorobenzyl)sulfanyl]-N-(methylsulfonyl)thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCE	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid via soaking Descriptor: 3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxylic acid, Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCM	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({N-[2-(methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCL	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid Descriptor: 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCK	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid Descriptor: 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCD	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, trigonal crystal form Descriptor: ACETIC ACID, Receptor-type tyrosine-protein phosphatase gamma, VANADATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCI	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide Descriptor: N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QKQ	Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... Authors: Brandao, T.A.S, Johnson, S.J, Hengge, A.C. Deposit date: 2011-02-01 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3QCJ	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid Descriptor: 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCB	Human receptor protein tyrosine phosphatase gamma, domain 1, apo Descriptor: Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCN	Human receptor protein tyrosine phosphatase gamma, domain 1, trigonal crystal form Descriptor: Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QKP	Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Brandao, T.A.S, Johnson, S.J, Hengge, A.C. Deposit date: 2011-02-01 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3RO1	Crystal structure of the complex of the archaeal sulfolobus PTP-fold phosphatase with terpyridine platinum(II) Descriptor: 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride, protein tyrosine phosphatase Authors: Lo, Y.-C, Wang, A.H.-J. Deposit date: 2011-04-25 Release date: 2011-10-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine. J.Biomol.Struct.Dyn., 29, 2011
3S3H	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4 Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3F	Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S4O	Protein Tyrosine Phosphatase (putative) from Leishmania major Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase-like protein, THIOSULFATE Authors: Merritt, E.A, Arakaki, T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP) Deposit date: 2011-05-19 Release date: 2011-06-15 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Protein Tyrosine Phosphatase from Leishmania major To be Published
3S3K	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate Descriptor: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, Tyrosine-protein phosphatase 10D Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3E	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
8YHI	The Crystal Structure of SHP1 from Biortus. Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 Authors: Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z. Deposit date: 2024-02-28 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The Crystal Structure of SHP1 from Biortus. To Be Published
8SLT	Crystal structure of human STEP (PTPN5) at physiological temperature (310 K) and ambient pressure (0.1 MPa) Descriptor: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 Authors: Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A. Deposit date: 2023-04-24 Release date: 2023-06-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. Biorxiv, 2023
8SLS	Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and ambient pressure (0.1 MPa) Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 Authors: Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A. Deposit date: 2023-04-24 Release date: 2023-06-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. Biorxiv, 2023
8SLU	Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and high pressure (205 MPa) Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 Authors: Ebrahim, A, Guerrero, L, Riley, B.T, Kim, M, Huang, Q, Finke, A.D, Keedy, D.A. Deposit date: 2023-04-24 Release date: 2023-06-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Pushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase. Biorxiv, 2023
8U1E	Apo protein tyrosine phosphatase 1B (PTP1B) at high resolution (1.43 A) in space group P43212 with two distinctly ordered chains Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Sharma, S, Mehlman, S.T, Keedy, A.D. Deposit date: 2023-08-31 Release date: 2023-09-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.43 Å) Cite: High-resolution double vision of the allosteric phosphatase PTP1B. Acta Crystallogr.,Sect.F, 80, 2024
8SKL	PTP1B in complex with 182 Descriptor: 1,2-ETHANEDIOL, 5-[1-fluoro-3-hydroxy-7-(3-hydroxy-3-methylbutoxy)naphthalen-2-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, CHLORIDE ION, ... Authors: Babon, J.J, Chen, H, Tiganis, T. Deposit date: 2023-04-20 Release date: 2023-08-02 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.55 Å) Cite: A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nat Commun, 14, 2023
8XOY	The Crystal Structure of PTP1B from Biortus. Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... Authors: Wang, F, Cheng, W, Lv, Z, Meng, Q, Li, J. Deposit date: 2024-01-02 Release date: 2024-01-24 Method: X-RAY DIFFRACTION (1.55 Å) Cite: The Crystal Structure of PTP1B from Biortus. To Be Published

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