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5GJJ
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BU of 5gjj by Molmil
Glutathionylated hHsp70 SBD
Descriptor: Heat shock 70 kDa protein 1A
Authors:Gong, W.B, Yang, J, Zhang, H, Perrett, S.
Deposit date:2016-06-30
Release date:2017-07-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of glutathionylated hHsp70 SBD (385-641)
To Be Published
6NHK
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BU of 6nhk by Molmil
Mortalin nucleotide binding domain in the ADP-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Page, R.C, Moseng, M.A, Nix, J.C.
Deposit date:2018-12-23
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.777 Å)
Cite:Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
2KHO
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BU of 2kho by Molmil
NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate
Descriptor: Heat shock protein 70
Authors:Zuiderweg, E.R.P, Bertelsen, E.B.
Deposit date:2009-04-10
Release date:2009-05-12
Last modified:2021-08-18
Method:SOLUTION NMR
Cite:Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.
Proc.Natl.Acad.Sci.USA, 106, 2009
2V7Z
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BU of 2v7z by Molmil
Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK COGNATE 71 KDA PROTEIN, PHOSPHATE ION
Authors:Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D.
Deposit date:2007-08-02
Release date:2008-04-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation.
J.Biol.Chem., 283, 2008
2V7Y
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BU of 2v7y by Molmil
Crystal structure of the molecular chaperone DnaK from Geobacillus kaustophilus HTA426 in post-ATP hydrolysis state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION, ...
Authors:Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D.
Deposit date:2007-08-02
Release date:2008-04-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation.
J.Biol.Chem., 283, 2008
7RAX
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BU of 7rax by Molmil
ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2021-07-04
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Visualization of Hsp70-catalyzed ATP Hydrolysis
To Be Published
6SR6
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BU of 6sr6 by Molmil
Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ...
Authors:Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I.
Deposit date:2019-09-05
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.
Nat Commun, 11, 2020
5TKY
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BU of 5tky by Molmil
Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein
Authors:Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I.
Deposit date:2016-10-10
Release date:2016-11-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
Nat Commun, 7, 2016
1U00
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BU of 1u00 by Molmil
HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC
Descriptor: Chaperone protein hscA, IscU recognition peptide
Authors:Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E.
Deposit date:2004-07-12
Release date:2004-10-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC.
J.Mol.Biol., 342, 2004
5UMB
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BU of 5umb by Molmil
Crystal structure of ATPase domain of Malaria GRP78 with ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ...
Authors:Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H.
Deposit date:2017-01-26
Release date:2022-07-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Repurposing drugs to target the malaria parasite unfolding protein response.
Sci Rep, 8, 2018
6ZHI
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BU of 6zhi by Molmil
Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide
Descriptor: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70
Authors:Schmidt, J, Vakonakis, I.
Deposit date:2020-06-23
Release date:2020-09-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the PfHsp70-x SBD
Acta Crystallographica Section F
4B9Q
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BU of 4b9q by Molmil
Open conformation of ATP-bound Hsp70 homolog DnaK
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION
Authors:Kopp, J, Mayer, M.P, Sinning, I.
Deposit date:2012-09-06
Release date:2012-11-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones
Mol.Cell, 48, 2012
6P2U
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BU of 6p2u by Molmil
Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate
Descriptor: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Moseng, M.A, Page, R.C.
Deposit date:2019-05-22
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
Febs Lett., 593, 2019
6PMT
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BU of 6pmt by Molmil
Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate
Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ...
Authors:Moseng, M.A, Nix, J.C, Page, R.C.
Deposit date:2019-07-02
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate
to be published
5MKR
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BU of 5mkr by Molmil
HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation
Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A
Authors:Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M.
Deposit date:2016-12-05
Release date:2017-03-01
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Angew. Chem. Int. Ed. Engl., 56, 2017
5MB9
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BU of 5mb9 by Molmil
Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I.
Deposit date:2016-11-07
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.
Nat. Struct. Mol. Biol., 24, 2017
5MKS
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BU of 5mks by Molmil
HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation
Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A
Authors:Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M.
Deposit date:2016-12-05
Release date:2017-03-01
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Angew. Chem. Int. Ed. Engl., 56, 2017
6S02
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BU of 6s02 by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION
Authors:Vakonakis, I, Day, J.
Deposit date:2019-06-13
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite.
Faseb J., 33, 2019
6RZQ
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BU of 6rzq by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state
Descriptor: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ...
Authors:Vakonakis, I, Day, J.
Deposit date:2019-06-13
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite.
Faseb J., 33, 2019
1BPR
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BU of 1bpr by Molmil
NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, MINIMIZED AVERAGE STRUCTURE
Descriptor: DNAK
Authors:Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P.
Deposit date:1998-08-11
Release date:1999-03-02
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction.
Biochemistry, 37, 1998
1ATS
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BU of 1ats by Molmil
THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION
Authors:O'Brien, M.C, Mckay, D.B.
Deposit date:1993-08-09
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis.
J.Biol.Chem., 268, 1993
1BA0
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BU of 1ba0 by Molmil
HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL 1NGE 3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ...
Authors:Wilbanks, S.M, Mckay, D.B.
Deposit date:1998-04-21
Release date:1998-07-15
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70.
Biochemistry, 37, 1998
1BA1
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BU of 1ba1 by Molmil
HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL MUTANT WITH CYS 17 REPLACED BY LYS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ...
Authors:Wilbanks, S.M, Mckay, D.B.
Deposit date:1998-04-21
Release date:1998-07-15
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70.
Biochemistry, 37, 1998
1ATR
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BU of 1atr by Molmil
THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION, ...
Authors:O'Brien, M.C, Mckay, D.B.
Deposit date:1993-08-09
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis.
J.Biol.Chem., 268, 1993
4R5K
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BU of 4r5k by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-B)
Descriptor: CALCIUM ION, Chaperone protein DnaK, SULFATE ION
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7469 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014

217705

數據於2024-03-27公開中

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