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1SPB
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BU of 1spb by Molmil
SUBTILISIN BPN' PROSEGMENT (77 RESIDUES) COMPLEXED WITH A MUTANT SUBTILISIN BPN' (266 RESIDUES). CRYSTAL PH 4.6. CRYSTALLIZATION TEMPERATURE 20 C DIFFRACTION TEMPERATURE-160 C
Descriptor: SODIUM ION, SUBTILISIN BPN', SUBTILISIN BPN' PROSEGMENT
Authors:Gallagher, D.T, Gilliland, G.L, Wang, L, Bryan, P.N.
Deposit date:1995-06-21
Release date:1995-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'.
Structure, 3, 1995
5OCA
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BU of 5oca by Molmil
PCSK9:Fab Complex with Dextran Sulfate
Descriptor: 2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ...
Authors:Thirup, S.S, Vilstrup, J.P.
Deposit date:2017-06-30
Release date:2017-09-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Nat Commun, 8, 2017
4YN3
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BU of 4yn3 by Molmil
Crystal structure of Cucumisin complex with pro-peptide
Descriptor: CHLORIDE ION, Cucumisin, DI(HYDROXYETHYL)ETHER, ...
Authors:Murayama, K, Kato-Murayama, M, Yokoyama, S, Arima, K, Shirouzu, M.
Deposit date:2015-03-09
Release date:2016-03-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of cucumisin protease activity regulation by its propeptide
J. Biochem., 161, 2017
1SCJ
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BU of 1scj by Molmil
CRYSTAL STRUCTURE OF SUBTILISIN-PROPEPTIDE COMPLEX
Descriptor: CALCIUM ION, SUBTILISIN E
Authors:Berman, H.M, Jain, S.C.
Deposit date:1998-04-29
Release date:1998-12-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution.
J.Mol.Biol., 284, 1998
4K8R
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BU of 4k8r by Molmil
An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo
Descriptor: Fab1, heavy chain, light chain, ...
Authors:Schiele, F, Nar, H.
Deposit date:2013-04-18
Release date:2013-05-08
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:An Antibody against the C-Terminal Domain of PCSK9 Lowers LDL Cholesterol Levels In Vivo.
J.Mol.Biol., 426, 2014
8U45
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BU of 8u45 by Molmil
Crystal Structure Analysis of Aspergillus fumigatus alkaline protease
Descriptor: Alkaline protease 1, CALCIUM ION, CHLORIDE ION, ...
Authors:Fernandez, D, Diec, D.D.L, Guo, W, Russi, S.
Deposit date:2023-09-08
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.
Sci Rep, 13, 2023
7KFA
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BU of 7kfa by Molmil
PCSK9 in complex with PCSK9i a 13mer cyclic peptide LDLR disruptor
Descriptor: 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ...
Authors:Chopra, R, Xu, M, Spraggon, G.
Deposit date:2020-10-13
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Cell Chem Biol, 29, 2022
7KEV
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BU of 7kev by Molmil
PCSK9 in complex with a cyclic peptide LDLR disruptor
Descriptor: CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9 Propeptide, ...
Authors:Spraggon, G, Chopra, R.
Deposit date:2020-10-12
Release date:2021-11-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Cell Chem Biol, 29, 2022
8WFR
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BU of 8wfr by Molmil
The Crystal Structure of PCSK9 from Biortus.
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y.
Deposit date:2023-09-20
Release date:2023-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Crystal Structure of PCSK9 from Biortus.
To Be Published
7S5H
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BU of 7s5h by Molmil
PCSK9(deltaCRD) in complex with cyclic peptide 35
Descriptor: (2E)-but-2-ene-1,4-diol, Pro-peptide from Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, ...
Authors:Orth, P.
Deposit date:2021-09-10
Release date:2021-11-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.272 Å)
Cite:A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J.Med.Chem., 64, 2021
7S5G
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BU of 7s5g by Molmil
PCSK9 in complex with compound 19
Descriptor: (2E)-but-2-ene-1,4-diol, 8VH-Z02-ALA-DAL-PHE-FTR-PRO-THR-0A1-3WX, GLYCEROL, ...
Authors:Orth, P.
Deposit date:2021-09-10
Release date:2021-11-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.041 Å)
Cite:A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J.Med.Chem., 64, 2021
3SQO
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BU of 3sqo by Molmil
PCSK9 J16 Fab complex
Descriptor: J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ...
Authors:Strop, P.
Deposit date:2011-07-05
Release date:2012-05-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J.Pharmacol.Exp.Ther., 340, 2012
3WHI
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BU of 3whi by Molmil
Crystal structure of unautoprocessed form of IS1-inserted Pro-subtilisin E
Descriptor: CALCIUM ION, Subtilisin E
Authors:Uehara, R, Angkawidjaja, C, Koga, Y, Kanaya, S.
Deposit date:2013-08-26
Release date:2013-12-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Formation of the High-Affinity Calcium Binding Site in Pro-subtilisin E with the Insertion Sequence IS1 of Pro-Tk-subtilisin
Biochemistry, 52, 2013
3GCX
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BU of 3gcx by Molmil
PCSK9:EGFA (pH 7.4)
Descriptor: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
Authors:McNutt, M.C, Kwon, H.J, Chen, C, Chen, J.R, Horton, J.D, Lagace, T.A.
Deposit date:2009-02-22
Release date:2009-03-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3GCW
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BU of 3gcw by Molmil
PCSK9:EGFA(H306Y)
Descriptor: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
Authors:Kwon, H.J.
Deposit date:2009-02-22
Release date:2009-03-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3M0C
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BU of 3m0c by Molmil
The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
Descriptor: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
Authors:Spraggon, G, Hampton, E.N.
Deposit date:2010-03-02
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (7.01 Å)
Cite:The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
To be Published
3H42
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BU of 3h42 by Molmil
Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody
Descriptor: Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, Proprotein convertase subtilisin/kexin type 9, ...
Authors:Piper, D.E, Walker, N.P.C, Romanow, W.G, Thibault, S.T, Tsai, M.M, Yang, E.
Deposit date:2009-04-17
Release date:2009-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc.Natl.Acad.Sci.USA, 106, 2009
4NE9
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BU of 4ne9 by Molmil
PCSK9 in complex with LDLR peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ...
Authors:Liu, S.
Deposit date:2013-10-28
Release date:2014-09-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Chem.Biol., 21, 2014
3P5B
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BU of 3p5b by Molmil
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
Descriptor: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
Authors:Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
4NMX
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BU of 4nmx by Molmil
PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8
Descriptor: Proprotein convertase subtilisin/kexin type 9, peptide 2-8
Authors:Eigenbrot, C, Shia, S.
Deposit date:2013-11-15
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor.
J.Biol.Chem., 289, 2014
2P4E
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BU of 2p4e by Molmil
Crystal Structure of PCSK9
Descriptor: MERCURY (II) ION, Proprotein convertase subtilisin/kexin type 9
Authors:Cunningham, D, Danley, D.E, Geoghegan, F.K, Griffor, M.C, Hawkins, J.L, Qiu, X.
Deposit date:2007-03-12
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
Nat.Struct.Mol.Biol., 14, 2007
3P5C
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BU of 3p5c by Molmil
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
Descriptor: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
Authors:Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
Deposit date:2010-10-08
Release date:2011-10-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
2PMW
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BU of 2pmw by Molmil
The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)
Descriptor: Proprotein convertase subtilisin/kexin type 9, SULFATE ION
Authors:Piper, D.E, Romanow, W.G, Thibault, S.T, Walker, N.P.C.
Deposit date:2007-04-23
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol.
Structure, 15, 2007
4OV6
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BU of 4ov6 by Molmil
Crystal structure of PCSK9(53-451) with Adnectin
Descriptor: 1,2-ETHANEDIOL, Adnectin, Proprotein convertase subtilisin/kexin type 9, ...
Authors:Khan, J.A.
Deposit date:2014-02-20
Release date:2014-07-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering.
J.Pharmacol.Exp.Ther., 350, 2014
2QTW
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BU of 2qtw by Molmil
The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ...
Authors:Hampton, E.N, Knuth, M.W, Li, J, Harris, J.L, Lesley, S.A, Spraggon, G.
Deposit date:2007-08-02
Release date:2007-09-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Proc.Natl.Acad.Sci.Usa, 104, 2007

 

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數據於2024-03-27公開中

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