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4XXO
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BU of 4xxo by Molmil
Crystal Structure of Human APOBEC3A
Descriptor: CHLORIDE ION, DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Bohn, M.F, Shandilya, S.M.D, Schiffer, C.A.
Deposit date:2015-01-30
Release date:2015-04-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.843 Å)
Cite:The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Structure, 23, 2015
7UXD
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BU of 7uxd by Molmil
Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy Zebularine.
Descriptor: DNA (5'-D(*AP*AP*TP*CP*CP*(DDN)P*AP*AP*A)-3'), DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Maiti, A, Matsuo, H.
Deposit date:2022-05-05
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.
Nat Commun, 13, 2022
5KEG
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BU of 5keg by Molmil
Crystal structure of APOBEC3A in complex with a single-stranded DNA
Descriptor: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ...
Authors:Kouno, T, Hilbert, B.J, Silvas, T, Royer, W.E, Matsuo, H, Schiffer, C.A.
Deposit date:2016-06-09
Release date:2017-05-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Nat Commun, 8, 2017
3E1U
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BU of 3e1u by Molmil
The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Holden, L, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S.
Deposit date:2008-08-04
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.
Nature, 456, 2008
6BUX
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BU of 6bux by Molmil
CRYSTAL STRUCTURE OF APOBEC3G CATALYTIC DOMAIN COMPLEX WITH SUBSTRATE SSDNA
Descriptor: Apolipoprotein B mRNA editing enzyme catalytic subunit 3G catalytic domain, DNA (5'-D(*AP*AP*TP*CP*CP*CP*AP*AP*A)-3'), GLYCEROL, ...
Authors:Maiti, A, Matsuo, H.
Deposit date:2017-12-11
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.856 Å)
Cite:Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
Nat Commun, 9, 2018
4ROV
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BU of 4rov by Molmil
The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Lu, X, Zhang, T, Xu, Z, Liu, S, Zhao, B, Lan, W, Wang, C, Ding, J, Cao, C.
Deposit date:2014-10-29
Release date:2014-12-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA
J.Biol.Chem., 290, 2015
4ROW
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BU of 4row by Molmil
The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Lu, X, Zhang, T, Xu, Z, Liu, S, Zhao, B, Lan, W, Wang, C, Ding, J, Cao, C.
Deposit date:2014-10-29
Release date:2014-12-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA
J.Biol.Chem., 290, 2015
3IR2
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BU of 3ir2 by Molmil
Crystal structure of the APOBEC3G catalytic domain
Descriptor: CHLORIDE ION, DNA dC->dU-editing enzyme APOBEC-3G, MAGNESIUM ION, ...
Authors:Shandilya, S.M.D, Schiffer, C.A.
Deposit date:2009-08-21
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces.
Structure, 18, 2010
3IQS
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BU of 3iqs by Molmil
Crystal structure of the anti-viral APOBEC3G catalytic domain
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Holden, L.G, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S.
Deposit date:2009-08-20
Release date:2009-11-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.
Nature, 456, 2008
3V4K
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BU of 3v4k by Molmil
First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G
Descriptor: CHLORIDE ION, DNA dC->dU-editing enzyme APOBEC-3G, MAGNESIUM ION, ...
Authors:Shandilya, S.M.D, Ali, A, Schiffer, C.A.
Deposit date:2011-12-15
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G.
Acs Chem.Biol., 7, 2012
3V4J
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BU of 3v4j by Molmil
First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G
Descriptor: 4-[methyl(nitroso)amino]benzene-1,2-diol, DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Shandilya, S.M.D, Ali, A, Schiffer, C.A.
Deposit date:2011-12-15
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G.
Acs Chem.Biol., 7, 2012
2M65
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BU of 2m65 by Molmil
NMR structure of human restriction factor APOBEC3A
Descriptor: Probable DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Byeon, I.L, Byeon, C, Ahn, J, Gronenborn, A.M.
Deposit date:2013-03-21
Release date:2013-05-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity.
Nat Commun, 4, 2013
7D3V
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BU of 7d3v by Molmil
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Cao, C.Y, Liu, Y.P, Lan, W.X.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3
To Be Published
7D3W
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BU of 7d3w by Molmil
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Cao, C, Liu, Y, Lan, W.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Two different kinds of interaction modes of deaminase APOBEC3A with single-stranded DNA in solution detected by nuclear magnetic resonance.
Protein Sci., 31, 2022
7D3X
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BU of 7d3x by Molmil
Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed by APOBEC3A
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION
Authors:Cao, C, Liu, Y.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Two different kinds of interaction modes of deaminase APOBEC3A with single-stranded DNA in solution detected by nuclear magnetic resonance.
Protein Sci., 31, 2022
2NBQ
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BU of 2nbq by Molmil
NMR Structure of the C-Terminal Domain of human APOBEC3B
Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION
Authors:Byeon, I.L, Byeon, C, Gronenborn, A.M.
Deposit date:2016-03-09
Release date:2016-06-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity.
Biochemistry, 55, 2016
2NYT
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BU of 2nyt by Molmil
The APOBEC2 Crystal Structure and Functional Implications for AID
Descriptor: Probable C->U-editing enzyme APOBEC-2, ZINC ION
Authors:Prochnow, C, Bransteitter, R, Klein, M, Goodman, M, Chen, X.
Deposit date:2006-11-21
Release date:2007-01-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The APOBEC-2 crystal structure and functional implications for the deaminase AID.
Nature, 445, 2007
2JYW
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BU of 2jyw by Molmil
Solution structure of C-terminal domain of APOBEC3G
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Chen, K, Harjes, E, Gross, P.J, Fahmy, A, Lu, Y, Shindo, K, Harris, R.S, Matsuo, H.
Deposit date:2007-12-20
Release date:2008-02-26
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.
Nature, 452, 2008
2KEM
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BU of 2kem by Molmil
Extended structure of citidine deaminase domain of APOBEC3G
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Harjes, E, Gross, P.J, Chen, K, Lu, Y, Shindo, K, Nowarski, R, Gross, J.D, Kotler, M, Harris, R.S, Matsuo, H.
Deposit date:2009-01-30
Release date:2009-06-02
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model
J.Mol.Biol., 389, 2009
2KBO
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BU of 2kbo by Molmil
Structure, interaction, and real-time monitoring of the enzymatic reaction of wild type APOBEC3G
Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION
Authors:Furukawa, A, Nagata, T, Matsugami, A, Habu, Y, Sugiyama, R, Hayashi, F, Kobayashi, N, Yokoyama, S, Takaku, H, Katahira, M.
Deposit date:2008-12-04
Release date:2009-02-03
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G
Embo J., 28, 2009
5SXG
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BU of 5sxg by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Descriptor: 1,3-PROPANDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IMIDAZOLE, ...
Authors:Shi, K, Kurahashi, K, Aihara, H.
Deposit date:2016-08-09
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Sci Rep, 7, 2017
5SXH
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BU of 5sxh by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Descriptor: 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION
Authors:Shi, K, Kurahashi, K, Aihara, H.
Deposit date:2016-08-09
Release date:2017-12-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Sci Rep, 7, 2017
5SWW
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BU of 5sww by Molmil
Crystal Structure of Human APOBEC3A complexed with ssDNA
Descriptor: DNA 15-Mer, DNA dC->dU-editing enzyme APOBEC-3A, GLYCEROL, ...
Authors:Shi, K, Banerjee, S, Kurahashi, K, Aihara, H.
Deposit date:2016-08-09
Release date:2016-12-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.151 Å)
Cite:Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
Nat. Struct. Mol. Biol., 24, 2017
5TD5
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BU of 5td5 by Molmil
Crystal Structure of Human APOBEC3B variant complexed with ssDNA
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(P*TP*TP*CP*AP*T)-3'), ...
Authors:Shi, K, Banerjee, S, Kurahashi, K, Aihara, H.
Deposit date:2016-09-16
Release date:2016-12-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.718 Å)
Cite:Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
Nat. Struct. Mol. Biol., 24, 2017
5CQK
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BU of 5cqk by Molmil
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, GLYCEROL, SODIUM ION, ...
Authors:Shi, K, Kurahashi, K, Aihara, H.
Deposit date:2015-07-21
Release date:2015-10-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.
J.Biol.Chem., 290, 2015

 

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數據於2024-03-27公開中

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