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8ERT
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BU of 8ert by Molmil
NLRP3 PYD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:Wu, H, Xiao, L.
Deposit date:2022-10-12
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of the active NLRP3 inflammasome disc.
Nature, 613, 2023
1UCP
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BU of 1ucp by Molmil
NMR structure of the PYRIN domain of human ASC
Descriptor: Apoptosis-associated speck-like protein containing a CARD
Authors:Liepinsh, E, Barbals, R, Dahl, E, Sharipo, A, Staub, E, Otting, G.
Deposit date:2003-04-16
Release date:2003-11-04
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
J.Mol.Biol., 332, 2003
7E5B
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BU of 7e5b by Molmil
Crystal structure of ASC PYD Domain and Rb-B7
Descriptor: Apoptosis-associated speck-like protein containing a CARD, GLYCEROL, Repebody (Rb-B7)
Authors:Cho, H.S, Cha, J.S.
Deposit date:2021-02-18
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space.
Cell Death Discov, 9, 2023
2YU0
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BU of 2yu0 by Molmil
Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205
Descriptor: Interferon-activable protein 205
Authors:Sato, M, Tochio, N, Koshiba, S, Watanabe, M, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-05
Release date:2008-02-19
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205
To be Published
3J63
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BU of 3j63 by Molmil
Unified assembly mechanism of ASC-dependent inflammasomes
Descriptor: Apoptosis-associated speck-like protein containing a CARD
Authors:Lu, A, Magupalli, V.G, Ruan, J, Yin, Q, Atianand, M.K, Vos, M, Schroder, G.F, Fitzgerald, K.A, Wu, H, Egelman, E.H.
Deposit date:2013-12-05
Release date:2014-03-26
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes.
Cell(Cambridge,Mass.), 156, 2014
3QF2
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BU of 3qf2 by Molmil
Crystal structure of NALP3 PYD
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:Park, H.H, Bae, J.Y.
Deposit date:2011-01-21
Release date:2011-08-31
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly
J.Biol.Chem., 286, 2011
4EWI
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Crystal structure of the NLRP4 Pyrin domain
Descriptor: CHLORIDE ION, NACHT, LRR and PYD domains-containing protein 4, ...
Authors:Eibl, C, Hessenberger, M, Puehringer, S, Page, R, Diederichs, K, Peti, W.
Deposit date:2012-04-27
Release date:2012-09-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural and Functional Analysis of the NLRP4 Pyrin Domain.
Biochemistry, 51, 2012
6Z2G
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BU of 6z2g by Molmil
Crystal structure of human NLRP9 PYD
Descriptor: NACHT, LRR and PYD domains-containing protein 9
Authors:Marleaux, M, Anand, K, Geyer, M.
Deposit date:2020-05-15
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.
Febs Lett., 594, 2020
7K3R
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BU of 7k3r by Molmil
Cryo-EM structure of AIM2-PYD filament
Descriptor: Interferon-inducible protein AIM2
Authors:Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H.
Deposit date:2020-09-12
Release date:2021-05-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.
Nat Commun, 12, 2021
7PZD
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BU of 7pzd by Molmil
Cryo-EM structure of the NLRP3 PYD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:Hochheiser, I.V, Hagelueken, G, Behrmann, H, Behrmann, E, Geyer, M.
Deposit date:2021-10-12
Release date:2022-04-20
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.
Sci Adv, 8, 2022
7BSO
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BU of 7bso by Molmil
Crystal structure of the human NLRP9 pyrin domain
Descriptor: NACHT, LRR and PYD domains-containing protein 9
Authors:Park, H.H, Ha, H.J.
Deposit date:2020-03-31
Release date:2021-02-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal structure of the human NLRP9 pyrin domain reveals a bent N-terminal loop that may regulate inflammasome assembly.
Febs Lett., 594, 2020
2DO9
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BU of 2do9 by Molmil
Solution structure of the Pyrin/PAAD-DAPIN domain in mouse NALP10 (NACHT, leucine rich repeat and PYD containing 10)
Descriptor: NACHT-, LRR- and PYD-containing protein 10
Authors:Saito, K, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-28
Release date:2006-10-28
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the Pyrin/PAAD-DAPIN domain in mouse NALP10 (NACHT, leucine rich repeat and PYD containing 10)
To be Published
2DBG
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BU of 2dbg by Molmil
Solution structure of the Pyrin (PAAD-DAPIN) domain in human Myeloid cell nuclear differentiation antigen
Descriptor: Myeloid cell nuclear differentiation antigen
Authors:Saito, K, Inoue, M, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-15
Release date:2006-06-15
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the Pyrin (PAAD-DAPIN) domain in human Myeloid cell nuclear differentiation antigen
To be Published
2HM2
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BU of 2hm2 by Molmil
Solution structure of ASC2
Descriptor: Pyrin-only protein 1
Authors:Natarajan, A, Ghose, R, Hill, J.M.
Deposit date:2006-07-11
Release date:2006-07-25
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling
J.Biol.Chem., 281, 2006
6NCV
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BU of 6ncv by Molmil
Cryo-EM structure of NLRP6 PYD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 6
Authors:Shen, C, Fu, T.M, Wu, H.
Deposit date:2018-12-12
Release date:2019-01-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular mechanism for NLRP6 inflammasome assembly and activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
2KM6
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BU of 2km6 by Molmil
NMR structure of the NLRP7 Pyrin domain
Descriptor: NACHT, LRR and PYD domains-containing protein 7
Authors:Pinheiro, A, Proell, M, Schwarzenbacher, R, Peti, W.
Deposit date:2009-07-21
Release date:2010-06-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity.
J.Biol.Chem., 285, 2010
2L6A
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BU of 2l6a by Molmil
Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12
Descriptor: NACHT, LRR and PYD domains-containing protein 12
Authors:Pinheiro, A.S, Peti, W.
Deposit date:2010-11-17
Release date:2011-11-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The NLRP12 pyrin domain: structure, dynamics, and functional insights.
J.Mol.Biol., 413, 2011
2M5V
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BU of 2m5v by Molmil
Three-dimensional structure of human NLRP10/PYNOD pyrin domain
Descriptor: NACHT, LRR and PYD domains-containing protein 10
Authors:Su, M.Y, Chang, C.F, Chang, C.I.
Deposit date:2013-03-11
Release date:2013-04-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Three-Dimensional Structure of Human NLRP10/PYNOD Pyrin Domain Reveals a Homotypic Interaction Site Distinct from Its Mouse Homologue.
Plos One, 8, 2013
2N00
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BU of 2n00 by Molmil
NMR Solution structure of AIM2 PYD from Mus musculus
Descriptor: Interferon-inducible protein AIM2
Authors:Hou, X, Niu, X.
Deposit date:2015-03-01
Release date:2015-05-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The NMR solution structure of AIM2 PYD domain from Mus musculus reveals a distinct alpha 2-alpha 3 helix conformation from its human homologues
Biochem.Biophys.Res.Commun., 461, 2015
2MPC
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BU of 2mpc by Molmil
Solution structure of the pyrin domain of human Pyrin
Descriptor: Pyrin
Authors:Soh, S.L, Smith, S.J, Hill, J.M.
Deposit date:2014-05-15
Release date:2014-07-16
Last modified:2022-08-24
Method:SOLUTION NMR
Cite:Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.
J.Biol.Chem., 289, 2014
2NAQ
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BU of 2naq by Molmil
3D NMR solution structure of NLRP3 PYD
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:de Alba, E, Oroz, J.
Deposit date:2016-01-07
Release date:2016-07-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces.
J.Biol.Chem., 291, 2016
2N1F
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BU of 2n1f by Molmil
Structure and assembly of the mouse ASC filament by combined NMR spectroscopy and cryo-electron microscopy
Descriptor: Apoptosis-associated speck-like protein
Authors:Sborgi, L, Ravotti, F, Dandey, V, Dick, M, Mazur, A, Reckel, S, Chami, M, Scherer, S, Bockmann, A, Egelman, E, Stahlberg, H, Broz, P, Meier, B, Hiller, S.
Deposit date:2015-04-01
Release date:2015-10-14
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR
Cite:Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.
Proc.Natl.Acad.Sci.USA, 112, 2015
4N1J
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BU of 4n1j by Molmil
Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Descriptor: GLYCEROL, NACHT, LRR and PYD domains-containing protein 14
Authors:Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H.
Deposit date:2013-10-04
Release date:2014-07-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
Acta Crystallogr.,Sect.D, 70, 2014
4N1L
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BU of 4n1l by Molmil
Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Descriptor: NACHT, LRR and PYD domains-containing protein 14
Authors:Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H.
Deposit date:2013-10-04
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
Acta Crystallogr.,Sect.D, 70, 2014
4N1K
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BU of 4n1k by Molmil
Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Descriptor: NACHT, LRR and PYD domains-containing protein 14
Authors:Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H.
Deposit date:2013-10-04
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
Acta Crystallogr.,Sect.D, 70, 2014

 

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數據於2024-03-27公開中

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