Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2HCN
DownloadVisualize
BU of 2hcn by Molmil
Crystal structure of RNA dependent RNA polymerase domain from west nile virus
Descriptor: CALCIUM ION, RNA-directed RNA polymerase (NS5), ZINC ION
Authors:Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-17
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HCS
DownloadVisualize
BU of 2hcs by Molmil
Crystal structure of RNA dependant RNA polymerase domain of West Nile virus
Descriptor: RNA-directed RNA polymerase (NS5), ZINC ION
Authors:Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-18
Release date:2007-02-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HFZ
DownloadVisualize
BU of 2hfz by Molmil
Crystal structure of RNA dependent RNA polymerase domain from West Nile virus
Descriptor: MAGNESIUM ION, RNA-directed RNA polymerase(NS5), ZINC ION
Authors:Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-26
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2J7U
DownloadVisualize
BU of 2j7u by Molmil
Dengue virus NS5 RNA dependent RNA polymerase domain
Descriptor: CHLORIDE ION, MAGNESIUM ION, RNA DEPENDENT RNA POLYMERASE, ...
Authors:Yap, T.L, Xu, T, Chen, Y.L, Malet, H, Egloff, M.P, Canard, B, Vasudevan, S.G, Lescar, J.
Deposit date:2006-10-17
Release date:2007-03-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81, 2007
2J7W
DownloadVisualize
BU of 2j7w by Molmil
Dengue virus NS5 RNA dependent RNA polymerase domain complexed with 3' dGTP
Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-TRIPHOSPHATE, POLYPROTEIN, ...
Authors:Yap, T.L, Xu, T, Chen, Y.L, Malet, H, Egloff, M.P, Canard, B, Vasudevan, S.G, Lescar, J.
Deposit date:2006-10-17
Release date:2007-03-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81, 2007
3VWS
DownloadVisualize
BU of 3vws by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107
Descriptor: 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, Non-structural protein 5, ...
Authors:Noble, C.G, Lescar, J.
Deposit date:2012-08-31
Release date:2013-02-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
J.Virol., 87, 2013
4HDH
DownloadVisualize
BU of 4hdh by Molmil
Crystal Structure of viral RdRp in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION
Authors:Surana, P, Nair, D.T.
Deposit date:2012-10-02
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4HDG
DownloadVisualize
BU of 4hdg by Molmil
Crystal Structure of viral RdRp in complex with GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION
Authors:Surana, P, Nair, D.T.
Deposit date:2012-10-02
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4HHJ
DownloadVisualize
BU of 4hhj by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase
Descriptor: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ...
Authors:Noble, C.G, Lescar, J.
Deposit date:2012-10-10
Release date:2013-02-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
J.Virol., 87, 2013
4K6M
DownloadVisualize
BU of 4k6m by Molmil
Crystal Structure of the full-length Japanese encephalitis virus NS5
Descriptor: Polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Lu, G, Gong, P.
Deposit date:2013-04-16
Release date:2013-08-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface
Plos Pathog., 9, 2013
4C11
DownloadVisualize
BU of 4c11 by Molmil
Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region
Descriptor: DENGUE VIRUS TYPE 3 RNA DEPENDENT RNA POLYMERASE, ZINC ION
Authors:Lim, S.P, Lescar, J.
Deposit date:2013-08-09
Release date:2013-08-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Polymerase Delineates Inter-Domain Amino Acids Residues that Enhance its Thermostability and De Novo Initiation Activities.
J.Biol.Chem., 288, 2013
4MTP
DownloadVisualize
BU of 4mtp by Molmil
RdRp from Japanesese Encephalitis Virus
Descriptor: RNA dependent RNA polymerase, ZINC ION
Authors:Surana, P, Nair, D.T.
Deposit date:2013-09-20
Release date:2013-12-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Nucleic Acids Res., 42, 2014
4V0Q
DownloadVisualize
BU of 4v0q by Molmil
Dengue Virus Full Length NS5 Complexed with SAH
Descriptor: ACETATE ION, GLYCEROL, NS5 POLYMERASE, ...
Authors:Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
4V0R
DownloadVisualize
BU of 4v0r by Molmil
DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH
Descriptor: FORMIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
5CCV
DownloadVisualize
BU of 5ccv by Molmil
Crystal structure of full-length NS5 from dengue virus type 3
Descriptor: RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
Authors:Klema, V.J, Choi, K.H.
Deposit date:2015-07-02
Release date:2016-02-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.
Plos Pathog., 12, 2016
5DTO
DownloadVisualize
BU of 5dto by Molmil
Dengue virus full length NS5 complexed with viral Cap 0-RNA and SAH
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, ACETATE ION, MAGNESIUM ION, ...
Authors:Zhao, Y, Soh, T.S, Lim, S.P, Chung, K.Y, Swaminathan, K, Vasudevan, S.G, Shi, P.-Y, Lescar, J, Luo, D.
Deposit date:2015-09-18
Release date:2015-11-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)
Proc.Natl.Acad.Sci.USA, 112, 2015
5F3Z
DownloadVisualize
BU of 5f3z by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to PC-79-SH52
Descriptor: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, Genome polyprotein, ZINC ION
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5F41
DownloadVisualize
BU of 5f41 by Molmil
DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO FD-83-KI26
Descriptor: 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid, Genome polyprotein, ZINC ION
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5F3T
DownloadVisualize
BU of 5f3t by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to JF-31-MG46
Descriptor: 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid, RNA-DEPENDENT RNA POLYMERASE, ZINC ION
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J.Biol.Chem., 291, 2016
5HN0
DownloadVisualize
BU of 5hn0 by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4
Descriptor: (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
5HMZ
DownloadVisualize
BU of 5hmz by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23
Descriptor: 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, RNA-directed RNA polymerase NS5, ZINC ION
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HMX
DownloadVisualize
BU of 5hmx by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10
Descriptor: 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HMY
DownloadVisualize
BU of 5hmy by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15
Descriptor: 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
5HMW
DownloadVisualize
BU of 5hmw by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5
Descriptor: 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5I3P
DownloadVisualize
BU of 5i3p by Molmil
DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Descriptor: 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, Genome polyprotein, ZINC ION
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016

 

123>

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon